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Earwax Test Accurately Detects Parkinson’s by Identifying Odor Molecules

QIAGEN and Incyte Enter into Precision Medicine Collaboration

New Technology Autonomously Detects AI Hallucinations in Digital Pathology

POC Lateral Flow Test Detects Deadly Fungal Infection Faster Than Existing Techniques

Portable Molecular POC System Rules Out UTIs in Just 35 Minutes

Cardiac Blood Markers Can Strongly Predict Future Cancer Risk

T Cells in Blood Can Detect Parkinson's Years Before Diagnosis

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Genetic Test Could Predict Poor Outcomes in Lung Transplant Patients

Image: Fc gamma-binding protein variant is linked to poor outcomes in lung transplant patients (Photo courtesy of Yun Hak Kim/Pusan National University)

A routine blood test could screen for a genetic biomarker of poor clinical outcomes following lung transplantation.
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01 Jul 2025

Breakthrough Blood Test Enables Early Pancreatic Cancer Detection

01 Jul 2025

Genomic Testing in NICU Reduces Missed Diagnoses

01 Jul 2025

New Genetic Test Improves Diabetes Prediction and Classification

01 Jul 2025

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30 Jun 2025

New Blood Test for Leukemia Risk Detection Could Replace Bone Marrow Sampling

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These images illustrate how precision oncology Organ Chips recapitulate individual patients’ responses to chemotherapy (Photo courtesy of Wyss Institute at Harvard University)

Cancer Chip Accurately Predicts Patient-Specific Chemotherapy Response

Esophageal adenocarcinoma (EAC), one of the two primary types of esophageal cancer, ranks as the sixth leading cause of cancer-related deaths worldwide and currently lacks effective targeted therapies. Read more
30 Jun 2025 | Pathology

Image: A routine blood sample in the first trimester can give an early warning for preeclampsia with high accuracy (Photo courtesy of 123RF)

Blood Test Detects Preeclampsia Risk Months Before Symptoms Appear

Preeclampsia, a pregnancy-related complication characterized by elevated blood pressure and organ dysfunction, remains a major contributor to maternal and infant health issues globally. Read more
30 Jun 2025 | Molecular Diagnostics

Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Read more
30 Jun 2025 | Immunology

Image: The Aiforia Breast Cancer Grading AI solution is CE-IVD marked (Photo courtesy of Aiforia Technologies)

Clinical AI Solution for Automatic Breast Cancer Grading Improves Diagnostic Accuracy

Labs that use traditional image analysis methods often suffer from bottlenecks and delays. By digitizing their pathology practices, labs can streamline their work, allowing them to take on larger caseloads while reducing turnaround times. Read more
27 Jun 2025 | Pathology

Image: Metagenomic sequencing could transform infectious disease diagnostics (Photo courtesy of 123RF)

mNGS CSF Test Outperforms Traditional Microbiological Testing for Infectious Diseases

Traditional, targeted tests for pathogen identification offer a frustrating guessing game with too many tests and too few answers. Read more
27 Jun 2025 | Molecular Diagnostics

Image: Newly-validated protein biomarkers pave the way for a POC cervical cancer screening test (Photo courtesy of UF Health Cancer Center)

Point-Of-Care Test to Transform Early-Stage Cervical Cancer Diagnosis

Cervical cancer is the world’s fourth most common cancer in women. When it’s found early, it’s one of the most preventable and treatable cancers. Read more
27 Jun 2025 | Molecular Diagnostics

Image: Saliva still remains underutilized in clinical practice (Photo courtesy of UPV/EHU)

Saliva-Based Testing to Enable Early Detection of Cancer, Heart Disease or Parkinson’s

Saliva is one of the most accessible biological fluids, yet it remains underutilized in clinical practice. Read more
27 Jun 2025 | Pathology

Image: Schematic overview of the deep learning-based circulating exosome analysis for lung cancer detection (Photo courtesy of Chuan Xu, Cheng Jiang)

Liquid Biopsy Approach to Transform Diagnosis, Monitoring and Treatment of Lung Cancer

Lung cancer continues to be a major contributor to cancer-related deaths globally, with its biological complexity and diverse regulatory processes making diagnosis and treatment particularly difficult. Read more
26 Jun 2025 | Immunology

Image: Example of multiple amplification of several targets as occurs in the syndromic panel (Photo courtesy of Marco Ciotti, Eleonora Nicolai, Massimo Pieri)

Advances in Monkeypox Virus Diagnostics to Improve Management of Future Outbreaks

Laboratory medicine plays a critical role in the diagnostic process, providing support for clinical decisions and guiding therapeutic interventions. Read more
26 Jun 2025 | Pathology

Image: Multitasking ctDNA can help guide lymphoma treatment (Photo courtesy of 123RF)

PET/ctDNA-Guided Approach Helps Determine Lymphoma Treatment

Currently, no diagnostic tests exist that can determine the genetic profile of a tumor in diffuse large B-cell lymphoma (DLBCL) before treatment, a critical factor for choosing the appropriate therapy. Read more
26 Jun 2025 | Molecular Diagnostics

Image: Tens of millions of nanoneedles could replace painful cancer biopsies (Photo courtesy of KCL)

Nanoneedle-Studded Patch Could Eliminate Painful and Invasive Biopsies

Biopsies are among the most frequently performed diagnostic procedures globally, carried out millions of times each year to detect various diseases. Read more
26 Jun 2025 | Pathology

Image: A rapid POC mNGS solution could achieve rapid turnaround diagnostics for respiratory viruses (Photo courtesy of 123RF)

Next-Generation 'Agnostic Diagnostics' to Detect Respiratory Viruses at POC

An international consortium is working on the development of rapid metagenomic next-generation sequencing (mNGS) tools that can detect both known and emerging respiratory pathogens, with the goal of shortening diagnostic timelines and strengthening hospital response and public health readiness. Read more
26 Jun 2025 | Molecular Diagnostics

Image: The new research involved using digital PCR as a reference method to standardize test results between laboratories (Photo courtesy of Adobe Stock)

New Reference Measurement Procedure Standardizes Nucleic Acid Amplification Test Results

Nucleic acid amplification tests (NAATs) play a key role in diagnosing a wide range of infectious diseases. Read more
26 Jun 2025 | Clinical Chem.

Image: The AI tool is set to transform the characterization and treatment of cancers (Photo courtesy of Garvan Institute)

AI Cancer Classification Tool to Drive Targeted Treatments

Tumors consist of more than just one type of cell—they are composed of a variety of cells that grow and respond to treatment in different ways. Read more
25 Jun 2025 | Pathology

Channels

Clinical Chemistry

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Image: A pen-like tool collects molecules from the skin that can be screened for opioids (Photo courtesy of William Clarke/Johns Hopkins)

Pen-Like Tool Quickly and Non-Invasively Detects Opioids from Skin

Opioid drugs such as fentanyl, morphine, and oxycodone are the primary substances associated with overdose cases in the United States. Standard drug screening procedures typically involve collecting blood,... Read more

Image: The spectroscopy and AI-powered urine-based test detects 10 cancers (Photo courtesy of 123RF)

Simple Urine Test Could Detect Multiple Cancers at Early Stage

When disease is present, the human body releases tiny molecules known as volatile organic compounds (VOCs). Now, a spectroscopy and artificial intelligence (AI)-powered urine-based test uses scent-based... Read more

Image: Ear wax could be a possible screening medium for Parkinson’s disease (Photo courtesy of 123RF)

Earwax Test Accurately Detects Parkinson’s by Identifying Odor Molecules

Current tests for Parkinson’s disease (PD) rely heavily on clinical scales and neuroimaging, which are often subjective, expensive, and ill-suited for routine screening. Since most treatments only slow... Read more

Image: New automated lab procedures can detect opioids in tiny amounts of blood (Photo courtesy of Tripathi Lab/Brown University)

First-Of-Its-Kind Quantitative Method Assesses Opioid Exposure in Newborns

As the opioid crisis continues to impact communities across the United States, laboratories encounter significant difficulties in accurately detecting opioid substances in individuals with opioid use disorder.... Read more

Molecular Diagnostics

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Image: Kissing bugs can carry the parasite that causes Chagas disease (Photo courtesy of 123RF)

First-Ever Test of Cure for Chagas Disease Determines Treatment Effectiveness

An estimated 6 to 8 million individuals across the globe are infected with Trypanosoma cruzi, the parasite responsible for Chagas disease, which claims over 10,000 lives annually. This disease doesn’t... Read more

Image: Capsule sponge opened to reveal the sponge (Photo courtesy of StillVision)

Capsule Sponge Test Could Replace Endoscopies for Monitoring Esophageal Cancer Risk

Esophageal cancer remains a challenging disease to treat, with fewer than 20% of patients surviving beyond five years of diagnosis—a statistic that has remained largely unchanged for decades.... Read more

Image: Researchers Ellen Foxman and Julien Amat have developed a nasal swab test that detects an antiviral protein, helping to rule out respiratory infections (Photo courtesy of Yale University)

Nasal Swab Test Offers Simpler and Less Costly Virus Screening in High-Risk Settings

PCR testing is the gold standard for detecting respiratory viruses, but it is costly and not well-suited for mass screening in high-risk environments like healthcare centers and nursing homes.... Read more

:Image: The genomic test can accurately predict resistance to treatment of three common types of chemotherapy (Photo courtesy of 123RF)

DNA Test Accurately Predicts Resistance to Common Chemotherapy Treatments

Chemotherapy remains a cornerstone of cancer treatment, but its toxicity to healthy cells can result in severe short- and long-term side effects. Despite its widespread use, not all patients respond to... Read more

Hematology

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Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Image: The FINDER multifunctional testing platform can run multiple types of tests and deliver rapid results for near-patient use (Photo courtesy of Baebies)

First Point-of-Care Heparin Monitoring Test Provides Results in Under 15 Minutes

Heparin dosing requires careful management to avoid both bleeding and clotting complications. In high-risk situations like extracorporeal membrane oxygenation (ECMO), mortality rates can reach about 50%,... Read more

Image: The 3-parameter CCRS model was devised specifically for patients diagnosed with clonal cytopenia (Photo courtesy of 123RF)

New Scoring System Predicts Risk of Developing Cancer from Common Blood Disorder

Clonal cytopenia of undetermined significance (CCUS) is a blood disorder commonly found in older adults, characterized by mutations in blood cells and a low blood count, but without any obvious cause or... Read more

Image: The technology has the unique ability to detect challenging RhD variants that are typically excluded by other commercial tests (Photo courtesy of BillionToOne)

Non-Invasive Prenatal Test for Fetal RhD Status Demonstrates 100% Accuracy

In the United States, approximately 15% of pregnant individuals are RhD-negative. However, in about 40% of these cases, the fetus is also RhD-negative, making the administration of RhoGAM unnecessary.... Read more

Immunology

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Image: The new tool shines a light on elusive genomic patterns (Photo courtesy of Adobe Stock)

Computational Tool Exposes Hidden Cancer DNA Changes Influencing Treatment Resistance

Structural changes in tumor DNA are among the most damaging genetic alterations in cancer, yet they often go undetected, particularly when tissue samples are degraded or of low quality. These hidden genomic... Read more

Image: NGS can detect one tumor cell among a million healthy cells from a simple blood sample (Photo courtesy of Shutterstock)

New Tool Detects Breast Cancer Relapses Five Years in Advance

Relapse detection in patients with solid tumors—particularly hormone receptor-positive (HR+) breast cancer—remains a major clinical challenge, as many patients initially respond well to treatment but later... Read more

T Cells in Blood Can Detect Parkinson's Years Before Diagnosis

Diagnosing Parkinson’s disease before the appearance of motor symptoms remains one of neurology’s most significant challenges. Patients can go years—even decades—without a diagnosis, as subtle early indicators... Read more

Image: The tip optofluidic immunoassay platform enables rapid, multiplexed antibody profiling using only 1 μL of fingertip blood (Photo courtesy of hLife, DOI:10.1016/j.hlife.2025.04.005)

POC Diagnostic Platform Performs Immune Analysis Using One Drop of Fingertip Blood

As new COVID-19 variants continue to emerge and individuals accumulate complex histories of vaccination and infection, there is an urgent need for diagnostic tools that can quickly and accurately assess... Read more

Microbiology

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Fecal Metabolite Profiling Predicts Mortality in Critically Ill Patients

Critically ill patients in medical intensive care units (MICUs) often suffer from conditions such as acute respiratory distress syndrome (ARDS) or sepsis, which are linked to reduced diversity of gut microbiota... Read more

Image: Lodestar UTI tests for six pathogen that, together, cause about 85% of all UTI infections (Photo courtesy of Llusern Scientific)

Portable Molecular POC System Rules Out UTIs in Just 35 Minutes

Urinary tract infections (UTIs) represent a massive burden on patients and healthcare systems. There are over 400 million UTI cases globally each year, of which around 90% are in women. Fast and accurate... Read more

POC Lateral Flow Test Detects Deadly Fungal Infection Faster Than Existing Techniques

Diagnosing mucormycosis—an aggressive and often deadly fungal infection—remains a major challenge due to the disease’s rapid progression and the lack of fast, accurate diagnostic tools. The problem became... Read more

Image: The U.S. FDA-cleared IntelliSep rapid host response diagnostic represents a breakthrough in sepsis care (Photo courtesy of Cytovale)

Rapid Diagnostic Test Slashes Sepsis Mortality by 39%

Sepsis remains one of the most challenging and fatal conditions in contemporary healthcare, accounting for nearly one-third of all hospital-related deaths in the United States. In emergency departments... Read more

Pathology

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Image: AI can help researchers understand lung disease and proposes treatment (Photo courtesy of YSM)

AI-Powered Imaging Enables Faster Lung Disease Treatment

Idiopathic pulmonary fibrosis (IPF) is a chronic and incurable lung disease that causes progressive scarring of lung tissue, severely impairing a person’s ability to breathe. Current treatments can only... Read more

Image: A new laboratory method could help detect rare immune disorders more quickly (Photo courtesy of 123RF)

New Laboratory Method Speeds Diagnosis of Rare Genetic Disease

Diagnosing genetic immune disorders like Activated-PI3Kδ syndrome (APDS) is often challenging, particularly when genetic testing reveals variants of uncertain significance (VUSs) rather than clearly pathogenic... Read more

New Technology Autonomously Detects AI Hallucinations in Digital Pathology

Traditional tissue staining, a fundamental tool in diagnosing diseases like cancer, involves chemical dyes to highlight microscopic features in tissue samples. While effective, the process is time-consuming,... Read more

Image: The new tool uses advanced computer models to identify different kinds of cells in tissues faster and more accurately (Photo courtesy of VCU)

Novel Algorithm Rapidly Identifies Cell Types to Improve Cancer Diagnosis

Determining the best treatment options for patients—whether for cancer therapy or drug prescriptions—relies heavily on accurately identifying cell types within complex tissues. Traditional methods of assigning... Read more

Technology

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New POC Biosensing Technology Improves Detection of Molecular Biomarkers

Traditional diagnostic procedures in medicine typically involve sending a patient’s blood or tissue samples to clinical laboratories, where trained scientists perform testing and data interpretation.... Read more

Enhanced Lab Data Management and AI Critical to Labs of the Future, Finds Survey

Data plays a key role in the transformation of today’s digital laboratories, acting both as a key challenge and a catalyst for innovation, as revealed by a survey of over 150 scientists.... Read more

Image: Structure of the herpes virus, nanopore module, and its waveform (Hashida et al., PNAS Nexus (2025), doi.org/10.1093/pnasnexus/pgaf161)

AI-Assisted Non-DNA Based Test Identifies Viral Infections in Minutes

Confirming viral infections typically involves DNA sequencing tests, which take hours and may not be available on-site. Moreover, these tests cannot differentiate between live and inactive virus particles.... Read more

Image: The machine learning-based method delivers near-perfect survival estimates for PAC patients (Photo courtesy of Shutterstock)

AI Method Predicts Overall Survival Rate of Prostate Cancer Patients

Prostate adenocarcinoma (PAC) accounts for 99% of prostate cancer diagnoses and is the second most common cancer in men globally after skin cancer. With more than 3.3 million men in the United States diagnosed... Read more

Industry

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Image: The AMP’s best practice recommendations are for clinical laboratories developing and performing HRD testing (Photo courtesy of 123RF)

AMP Releases Best Practice Recommendations to Guide Clinical Laboratories Offering HRD Testing

Homologous recombination deficiency (HRD) testing identifies tumors that are unable to effectively repair DNA damage through the homologous recombination repair pathway. This deficiency is often linked... Read more

Image: Illumina’s acquisition of SomaLogic aims to strengthen its presence in the proteomics market (Photo courtesy of Illumina)

Illumina Acquires SomaLogic to Accelerate Proteomics Business

Illumina, Inc. (San Diego, CA, USA) has entered into a definitive agreement to acquire SomaLogic (Boulder, CO, USA), a leader in data-driven proteomics technology, and other specified assets for USD 350... Read more

Image: The new partnership aims to develop oncology assays for use on the QIAcuityDx platform (Photo courtesy of QIAGEN)

Qiagen and Gencurix Partner on Development of QIAcuity Digital PCR IVD Assay

QIAGEN (Venlo, Netherlands) and GENCURIX (Seoul, South Korea) have entered into a new partnership to develop oncology assays for use on the QIAcuityDx platform, a high-performance digital PCR system designed... Read more

QIAGEN and Incyte Enter into Precision Medicine Collaboration

Myeloproliferative neoplasms (MPNs) are a closely related group of rare blood cancers representing about 40% of hematological malignancies, characterized by chronic accumulation of different mature blood... Read more

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