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AI Tool Identifies Gene Combinations Causing Complex Illnesses

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AI Model Detects More Than 170 Cancer Types

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Stronger Blood Clot Prevention Measures Needed After Leg Artery Procedures in High-Risk Patients

New Tool Detects Breast Cancer Relapses Five Years in Advance

Image: NGS can detect one tumor cell among a million healthy cells from a simple blood sample (Photo courtesy of Shutterstock)

A new tool monitors treatment response in patients with solid tumors from a simple blood sample.
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23 Jun 2025

Umbilical Cord Blood Test Can Detect Early Sepsis in Preterm Infants

23 Jun 2025

Simple Blood Test Predicts Cognitive Decline in Alzheimer's Patients

23 Jun 2025

New Laboratory Method Speeds Diagnosis of Rare Genetic Disease

23 Jun 2025

Fecal Metabolite Profiling Predicts Mortality in Critically Ill Patients

23 Jun 2025

Molecular Biomarkers Pave Way for New Tests to Diagnose and Predict Breast Cancer

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Image: Ear wax could be a possible screening medium for Parkinson’s disease (Photo courtesy of 123RF)

Earwax Test Accurately Detects Parkinson’s by Identifying Odor Molecules

Current tests for Parkinson’s disease (PD) rely heavily on clinical scales and neuroimaging, which are often subjective, expensive, and ill-suited for routine screening. Read more
20 Jun 2025 | Clinical Chem.

Image: Lodestar UTI tests for six pathogen that, together, cause about 85% of all UTI infections (Photo courtesy of Llusern Scientific)

Portable Molecular POC System Rules Out UTIs in Just 35 Minutes

Urinary tract infections (UTIs) represent a massive burden on patients and healthcare systems. There are over 400 million UTI cases globally each year, of which around 90% are in women. Read more
20 Jun 2025 | Microbiology

Image: The new partnership aims to develop oncology assays for use on the QIAcuityDx platform (Photo courtesy of QIAGEN)

Qiagen and Gencurix Partner on Development of QIAcuity Digital PCR IVD Assay

QIAGEN (Venlo, Netherlands) and GENCURIX (Seoul, South Korea) have entered into a new partnership to develop oncology assays for use on the QIAcuityDx platform, a high-performance digital PCR system designed for clinical diagnostics. Read more
20 Jun 2025 | Industry

Image: scopeDx uses proprietary type III CRISPR-Cas technology to enable rapid diagnostics at POC (Photo courtesy of Adobe Stock)

Portable CRISPR-Based Molecular Technology Brings Highly Accurate Diagnostics to Point of Need

A comprehensive solution for point-of-care diagnostics harnesses the power of CRISPR-Cas for extreme accuracy in an onsite setting. Read more
20 Jun 2025 | Molecular Diagnostics

Image: A prototype of the lateral flow test (Photo courtesy of University of Exeter)

POC Lateral Flow Test Detects Deadly Fungal Infection Faster Than Existing Techniques

Diagnosing mucormycosis—an aggressive and often deadly fungal infection—remains a major challenge due to the disease’s rapid progression and the lack of fast, accurate diagnostic tools. Read more
19 Jun 2025 | Microbiology

Image: Overview of the NAPTUNE detection process (Hu, T., Ke, X., Yu, Y. et al. Nat Commun 16, 1331 (2025). doi.org/10.1038/s41467-025-56653-9)

Palm-Sized Device Detects Disease-Related Genetic Material In 45 Minutes

Polymerase chain reaction (PCR) and real-time immunoassays are widely used for accurate diagnostics, but they come with key limitations. Read more
19 Jun 2025 | Molecular Diagnostics

Image: T cell immunity could be a marker for early Parkinson’s treatment (Photo courtesy of Shutterstock)

T Cells in Blood Can Detect Parkinson's Years Before Diagnosis

Diagnosing Parkinson’s disease before the appearance of motor symptoms remains one of neurology’s most significant challenges. Read more
19 Jun 2025 | Immunology

Image: A new tool improves the detection of hidden genetic mutations (Photo courtesy of 123RF)

Advanced Computational Tool Paves Way for Diagnostic Tests to Detect Hidden Genetic Mutations

Identifying genetic mutations at the protein level has long been a barrier in the field of proteogenomics, limiting scientists’ ability to fully understand disease mechanisms such as cancer or neurodegeneration. Read more
19 Jun 2025 | Molecular Diagnostics

Image: Virtual staining & autonomous quality and hallucination assessment (Photo courtesy of Ozcan Lab/UCLA)

New Technology Autonomously Detects AI Hallucinations in Digital Pathology

Traditional tissue staining, a fundamental tool in diagnosing diseases like cancer, involves chemical dyes to highlight microscopic features in tissue samples. Read more
19 Jun 2025 | Pathology

Image: The predictive power of certain cardiac blood markers may also encompass cancer risk (Photo courtesy of Adobe Stock)

Cardiac Blood Markers Can Strongly Predict Future Cancer Risk

Cancer and heart disease are traditionally treated as separate conditions, but new research suggests they may be more closely linked than previously believed. Read more
18 Jun 2025 | Molecular Diagnostics

Image: Study overview using cell-free DNA methylation patterns in blood to monitor cellular damages after liver transplant (Photo courtesy of Nature Communications)

New Blood Test to Reduce Liver Transplant Failures

Liver transplants are critical, life-saving procedures, but patients often face complications such as organ rejection and tissue injury, which are difficult to detect and treat in time. Read more
18 Jun 2025 | Molecular Diagnostics

Image: A global strategic collaboration will co-develop an NGS-based companion diagnostic panel for MPNs (Photo courtesy of QIAGEN)

QIAGEN and Incyte Enter into Precision Medicine Collaboration

Myeloproliferative neoplasms (MPNs) are a closely related group of rare blood cancers representing about 40% of hematological malignancies, characterized by chronic accumulation of different mature blood cell types in the blood. Read more
18 Jun 2025 | Industry

Image: A new study has found key blood proteins which predict future cognitive decline (Photo courtesy of Adobe Stock)

Protein Blood Test Could Predict Future Cognitive Decline

Identifying early signs of dementia remains a major clinical challenge, especially among individuals with co-existing conditions like cerebrovascular disease. Read more
18 Jun 2025 | Molecular Diagnostics

Image: The new tool uses advanced computer models to identify different kinds of cells in tissues faster and more accurately (Photo courtesy of VCU)

Novel Algorithm Rapidly Identifies Cell Types to Improve Cancer Diagnosis

Determining the best treatment options for patients—whether for cancer therapy or drug prescriptions—relies heavily on accurately identifying cell types within complex tissues. Read more
18 Jun 2025 | Pathology

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Clinical Chemistry

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Image: New automated lab procedures can detect opioids in tiny amounts of blood (Photo courtesy of Tripathi Lab/Brown University)

First-Of-Its-Kind Quantitative Method Assesses Opioid Exposure in Newborns

As the opioid crisis continues to impact communities across the United States, laboratories encounter significant difficulties in accurately detecting opioid substances in individuals with opioid use disorder.... Read more

Image: The paper-based devices at a study site (Photo courtesy of Abraham Badu-Tawiah/OSU)

Paper-Based Devices Outperform Existing Methods in Diagnosing Asymptomatic Malaria

Malaria is transmitted through the bites of mosquitoes that carry infectious parasites. According to estimates from the World Health Organization, in 2022, there were 249 million malaria cases worldwide,... Read more

Image: New research has linked skin barrier dysfunction to pediatric eosinophilic esophagitis (Photo courtesy of 123RF)

Simple Skin Test Could Revolutionize Diagnosis of Pediatric Eosinophilic Esophagitis

Eosinophilic esophagitis (EoE) is a chronic, food allergen-driven condition marked by inflammation and damage to the esophageal lining. Diagnosing EoE in children remains a clinical challenge, especially... Read more

Image: A new diagnostic tool shines a powerful new light into the viral darkness (Photo courtesy of Adobe Stock)

Portable Diagnostic Tool Uses Bioluminescence to Detect Viruses at POC

Point-of-care diagnostics have become crucial tools in many households, enabling individuals to measure blood sugar, conduct pregnancy tests, and even perform their own COVID-19 assays. These diagnostics... Read more

Molecular Diagnostics

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Image: A simple, non-invasive oral rinse enables earlier, more accurate diagnosis of oral cancer (Photo courtesy of 123RF)

Pioneering Saliva-Based Multiomic Platform to Transform Early Oral Cancer Detection

Head and neck cancers are the sixth most common. Yet, over 60% of cases are detected late, with late-stage oral cancer detection surging by more than 1.5X in the last two decades. The current standard... Read more

Image: The OnePCR system has received US FDA 510(k) clearance (Photo courtesy of Genes2Me)

Fully Automated Detection System Revolutionizes Point-Of-Care Testing

A state-of-the-art, fully automated system simplifies diagnostics by integrating nucleic acid extraction and real-time PCR (RT-PCR) detection into a single, streamlined process. Its user-friendly design,... Read more

Image: INDICAID HPV Urine Test can detect 14 types of high-risk HPV using patented urine DNA concentration technology (Photo courtesy of PHASE Scientific)

World’s First Urine-Based HPV Test to Transform Cervical Cancer Screening

Human papillomavirus (HPV) is a very common sexually transmitted infection (STI) that causes more than 95% of cervical cancer cases. Detection of HPV infections that lead to cellular transformation, followed... Read more

Image: Device architecture and measurement setup of an HJD-NP, with n-type MoS2 and p-type WSe2 (Photo courtesy of Grainger College of Engineering)

Novel Nanopore Sensing Platform Paves Way for Solid-State, Label-Free DNA Sequencing Technologies

Nanopore sensors are extremely small devices designed to detect and examine individual molecules by monitoring ionic changes as these molecules move through nanoscale pores. These sensors fall into two... Read more

Hematology

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Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Image: The FINDER multifunctional testing platform can run multiple types of tests and deliver rapid results for near-patient use (Photo courtesy of Baebies)

First Point-of-Care Heparin Monitoring Test Provides Results in Under 15 Minutes

Heparin dosing requires careful management to avoid both bleeding and clotting complications. In high-risk situations like extracorporeal membrane oxygenation (ECMO), mortality rates can reach about 50%,... Read more

Image: The 3-parameter CCRS model was devised specifically for patients diagnosed with clonal cytopenia (Photo courtesy of 123RF)

New Scoring System Predicts Risk of Developing Cancer from Common Blood Disorder

Clonal cytopenia of undetermined significance (CCUS) is a blood disorder commonly found in older adults, characterized by mutations in blood cells and a low blood count, but without any obvious cause or... Read more

Image: The technology has the unique ability to detect challenging RhD variants that are typically excluded by other commercial tests (Photo courtesy of BillionToOne)

Non-Invasive Prenatal Test for Fetal RhD Status Demonstrates 100% Accuracy

In the United States, approximately 15% of pregnant individuals are RhD-negative. However, in about 40% of these cases, the fetus is also RhD-negative, making the administration of RhoGAM unnecessary.... Read more

Immunology

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Image: The tip optofluidic immunoassay platform enables rapid, multiplexed antibody profiling using only 1 μL of fingertip blood (Photo courtesy of hLife, DOI:10.1016/j.hlife.2025.04.005)

POC Diagnostic Platform Performs Immune Analysis Using One Drop of Fingertip Blood

As new COVID-19 variants continue to emerge and individuals accumulate complex histories of vaccination and infection, there is an urgent need for diagnostic tools that can quickly and accurately assess... Read more

Image: Switching to an experimental drug after liquid biopsy detection of breast cancer recurrence can improve outcomes (Photo courtesy of Shutterstock)

Treatment Switching Guided by Liquid Biopsy Blood Tests Improves Outcomes for Breast Cancer Patients

Standard treatment for patients with advanced estrogen receptor (ER)-positive, HER2-negative breast cancer, a subtype driven by estrogen receptors that fuel tumor growth, often involves aromatase inhibitors,... Read more

Image: Custom hardware and software for the real-time detection of immune cell biophysical signatures in NICU (Photo courtesy of Pediatric Research, DOI:10.1038/s41390-025-03952-y)

First-Of-Its-Kind Device Profiles Newborns' Immune Function Using Single Blood Drop

Premature infants are highly susceptible to severe and life-threatening conditions, such as sepsis and necrotizing enterocolitis (NEC). Newborn sepsis, which is a bloodstream infection occurring in the... Read more

Image: The cancer stem cell test can accurately choose more effective treatments (Photo courtesy of University of Cincinnati)

Stem Cell Test Predicts Treatment Outcome for Patients with Platinum-Resistant Ovarian Cancer

Epithelial ovarian cancer frequently responds to chemotherapy initially, but eventually, the tumor develops resistance to the therapy, leading to regrowth. This resistance is partially due to the activation... Read more

Microbiology

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Image: The U.S. FDA-cleared IntelliSep rapid host response diagnostic represents a breakthrough in sepsis care (Photo courtesy of Cytovale)

Rapid Diagnostic Test Slashes Sepsis Mortality by 39%

Sepsis remains one of the most challenging and fatal conditions in contemporary healthcare, accounting for nearly one-third of all hospital-related deaths in the United States. In emergency departments... Read more

Image: The LIAISON PLEX® Gram-Positive Blood Culture Assay runs on the on the LIAISON PLEX instrument (Photo courtesy of Diasorin)

Blood Culture Assay Enhances Diagnostic Stewardship Through Targeted Panel Selection

Each year, around 250,000 individuals in the US are diagnosed with bloodstream infections (BSIs). Sepsis caused by these infections carries a mortality rate ranging from 16% to 40%, and any delay in administering... Read more

Image: Cutting-edge hospital genomics initiative takes on dangerous superbug (Photo courtesy of 123RF)

Real-Time Genome Sequencing Detects Dangerous Superbug Causing Hospital Infections

Superbug infections caused by Staphylococcus aureus, or ‘golden staph’, are notoriously difficult to treat and claim over one million lives globally each year. These bacteria can rapidly develop resistance... Read more

Diagnostic Test Accurately Detects Colorectal Cancer by Identifying Microbial Signature in Gut Bacteria

Colorectal cancer remains one of the deadliest and most common forms of cancer worldwide, with only 40% of cases diagnosed before metastasis. Current screening methods, like colonoscopy, are invasive and... Read more

Pathology

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AI Method Speeds Up Cancer Tracking Using Blood Tests

Current techniques for detecting cancer DNA in the bloodstream, referred to as circulating tumor DNA (ctDNA), often depend on complex and costly DNA sequencing to identify common mutations associated with cancer.... Read more

Image: The AI tool helps to automate the counting of different blood cell types contained in a blood or bone marrow sample (Photo courtesy of MSK)

New AI Tool Improves Blood Cancer Diagnosis

Traditionally, diagnosing blood and bone marrow cancers has involved doctors manually examining and classifying hundreds of cells under a microscope—an approach that is time-consuming but essential for... Read more

Novel Platform Technology Predicts Diseases by Early Detection of Aging Signals in Liver Tissue

Aging and chronic diseases are marked by the slow buildup of subtle tissue alterations over extended periods. However, quantitatively capturing these gradual changes within organs and associating them... Read more

Image: The AI model compares the epigenetic data of unknown tumors to the fingerprints of over 8,000 reference tumors (Photo courtesy of Philipp Euskirchen/Charité)

AI Model Detects More Than 170 Cancer Types

Diagnosing brain tumors can be especially difficult when the tumor is located in a region where biopsies pose high risks. In such scenarios, where obtaining tissue samples is not feasible, conventional... Read more

Technology

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New POC Biosensing Technology Improves Detection of Molecular Biomarkers

Traditional diagnostic procedures in medicine typically involve sending a patient’s blood or tissue samples to clinical laboratories, where trained scientists perform testing and data interpretation.... Read more

Enhanced Lab Data Management and AI Critical to Labs of the Future, Finds Survey

Data plays a key role in the transformation of today’s digital laboratories, acting both as a key challenge and a catalyst for innovation, as revealed by a survey of over 150 scientists.... Read more

Image: Structure of the herpes virus, nanopore module, and its waveform (Hashida et al., PNAS Nexus (2025), doi.org/10.1093/pnasnexus/pgaf161)

AI-Assisted Non-DNA Based Test Identifies Viral Infections in Minutes

Confirming viral infections typically involves DNA sequencing tests, which take hours and may not be available on-site. Moreover, these tests cannot differentiate between live and inactive virus particles.... Read more

Image: The machine learning-based method delivers near-perfect survival estimates for PAC patients (Photo courtesy of Shutterstock)

AI Method Predicts Overall Survival Rate of Prostate Cancer Patients

Prostate adenocarcinoma (PAC) accounts for 99% of prostate cancer diagnoses and is the second most common cancer in men globally after skin cancer. With more than 3.3 million men in the United States diagnosed... Read more

Industry

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Image: bioMérieux’s acquisition of Day Zero Diagnostics’ assets aims to strengthen its NGS capabilities (Photo courtesy of bioMérieux)

bioMérieux Acquires Day Zero Diagnostics Solutions and Technologies

bioMérieux (Marcy l’Étoile, France), a world leader in the field of in vitro diagnostics, has agreed to acquire the assets of Day Zero Diagnostics (Watertown, MA, USA), an infectious disease diagnostics... Read more

Image: The knowledge transfer partnership will further develop technology to rapidly diagnose serious and high-risk infectious diseases (Photo courtesy of Aston University)

Aston University and BG Research Partner to Commercialize Groundbreaking Medical Diagnostic

Technology that can rapidly diagnose high-consequence infectious diseases will take a major step forward towards commercialization, thanks to a new partnership. A Knowledge Transfer Partnership (KTP)... Read more

Image: The collaboration aims to speed up the adoption of ultrasensitive immunoassays incorporating single-molecule counting technology (Photo courtesy of Fujirebio)

Fujirebio Collaborates with Stanford Medicine to Advance Infectious Disease Research

Fujirebio (Tokyo, Japan) has entered into a collaboration with Stanford Medicine (Palo Alto, CA, USA) to accelerate the adoption of ultrasensitive immunoassays that incorporate single-molecule counting... Read more

Image: The LEX system brings together high speed and high sensitivity in a PCR molecular system to redefine POC diagnostics (Photo courtesy of LEX Diagnostics)

QuidelOrtho to Acquire MDx Company LEX Diagnostics

QuidelOrtho Corporation (San Diego, CA, USA) has announced a refocusing of its molecular diagnostics strategy which now includes acquiring LEX Diagnostics (Cambridgeshire, UK) and discontinuing development... Read more

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