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Rapid Mass Spectrometry Test May Aid Glioma Margin Decisions

Blood-Based Immune Signal Could Reveal Lung Cancer Risk Before Tumors Develop

Multi-Cancer Screening Blood Test Gains FDA Breakthrough Designation

Lollipop-Inspired Device Measures Acetaminophen Levels in Saliva

New Web-Based Platform Helps Autoimmune Laboratories Manage Testing Complexity

Regulatory Milestone Expands Access to Blood-Based Neurology Biomarker Testing in China

Pooled Sputum Testing Offers Lower-Cost Molecular Diagnosis for Tuberculosis

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New Surgical Technique Enlarges Aortic Root for Larger Valve Implantation

FDA Approval Expands Bridging Stent Use in Complex Aortic Aneurysm Repair

MRI Tool Analysis Identifies Vascular Differences in Cerebral Small Vessel Disease

Optical Imaging System Helps Predict Chemotherapy Response in Cancer

New Beam Measurement Approach Could Support More Precise Ion Therapy

AI Tool Classifies Pathogenic Variants in Severe Childhood Epilepsy

Image: Supervised learning facilitates the generation of an STXBP1-specific variant effect predictor, EpiPred. (Jeffrey D. Calhoun et al., Gene-specific machine learning model EpiPred identifies likely pathogenic variants in the epilepsy-related gene STXBP1, Journal of Clinical Investigation (2026). DOI: 10.1172/jci207160)

An AI approach predicts whether genetic variants cause disease, outperforming general tools and helping clarify uncertain epilepsy findings
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16 Oct 2026

Noninvasive Cervical Test Detects Endometrial Cancer for Triage

16 Oct 2026

Multimodal Clinical Data Models Predict Cachexia Risk Across Cancers

16 Oct 2026

Molecular Test Detects Barrett’s Esophagus to Guide Endoscopy Referral

16 Oct 2026

New Myelofibrosis Guidelines Recommend Expanded Genetic Testing at Diagnosis

16 Oct 2026

Handheld Point-of-Care Test Aims to Enable Rapid Coagulation Assessment in Trauma

16 Oct 2026

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Image: The discovery could enable early screening of young children, with the long-term goal of preventing pediatric cancers from developing later in childhood. (Image Credit: Shutterstock)

Blood Antibody Signals May Offer Clues to the Origins of Childhood Cancer

New findings identify blood-based immune markers that may flag increased childhood cancer risk years before diagnosis. Read more
16 Oct 2026 | BioResearch

Image: The test identifies individuals more likely to have elevated brain amyloid, with PET used for confirmation (Image Credit: Adobe Stock)

Study Evaluates Alzheimer’s Blood Biomarker Across Racial and Ethnic Groups

New data show that a blood-based Alzheimer’s marker tracks brain amyloid across diverse groups. Read more
15 Oct 2026 | Clinical Chem.

Image: The TriVerity Test System includes a disposable TriVerity cartridge and the Myrna instrument. It measures 29 host mRNAs from blood and uses machine learning to provide bacterial, viral, and illness severity scores in about 30 minutes. (Photo courtesy of Inflammatix)

Rapid Host-Response Test Aims to Predict Corticosteroid Benefit in Sepsis

An AI host-response test aims to predict corticosteroid benefit to guide care in severe infection and suspected sepsis. Read more
15 Oct 2026 | Microbiology

Image: Delve Bio has launched Delve Detect Plasma, expanding its mNGS-based pathogen detection portfolio beyond cerebrospinal fluid to blood. (photo courtesy of Delve Bio)

Blood-Based Metagenomic Test Detects Wide Range of Pathogens from Single Sample

A new blood-based mNGS test enables unbiased, next-day detection of diverse pathogens from a single sample. Read more
15 Oct 2026 | Molecular Diagnostics

Image: This sequence of images shows a cell containing micronuclei, which is undergoing cell death. Chromatin is stained in pink, and ring-shaped DNA in fluorescent green. The white dotted lines mark regions with micronuclei. (Photo courtesy of Aditi Gnanasekar, Stanford University)

Cancer DNA Trapping Mechanism Reveals Potential Target for Future Therapies

Trapping cancer-driving DNA outside the main nucleus can silence harmful gene activity and is linked to better neuroblastoma outcomes. Read more
15 Oct 2026 | BioResearch

Image Credit: iStock

Global TB Summit Connects Diagnostic Testing With Prevention and Clinical Care

QIAGEN’s Global TB Summit brings together experts to discuss tuberculosis prevention, screening, drug resistance, and access to care. Read more
15 Oct 2026 | Industry

Image: The collaboration centers on the SwiftLab Platform and SpectroChip’s photonic chip-based portable testing technology (Photo courtesy of Pur

Hospital Partnership Advances Clinical Validation of Portable Diagnostic Technology

A photonic-chip POC system enters clinical validation to enable lab-grade quantification of lateral-flow tests in under 5 min. Read more
15 Oct 2026 | Industry

Image: Seye Oladeji, graduate student and first author, holds up an example of a detection assay. (Photo courtesy of Rice University/Jared Jones)

New RNA Detection Tool Shows Promise for HIV and Other Viral Testing

A new CRISPR-based enzyme delivers more sensitive RNA detection while remaining heat-stable. Read more
14 Oct 2026 | Molecular Diagnostics

Image: TissueCypher analyzes protein biomarkers and tissue architecture in biopsy samples to estimate five-year risk of progression to high-grade dysplasia or esophageal adenocarcinoma. (Photo courtesy of Castle Biosciences)

Molecular Testing Refines Barrett’s Esophagus Progression Risk Beyond Biopsy Findings

A molecular test estimates five-year risk of high-grade dysplasia or cancer in Barrett’s esophagus, guiding care beyond pathology. Read more
14 Oct 2026 | Pathology

Image: The platform is designed to isolate extracellular vesicles originating from a selected tissue, with an initial focus on those released by hepatocytes in the liver. (Photo courtesy of Mursla Bio)

Tissue-Specific Vesicle Isolation Expands Molecular Insights Into Liver Disease

Mursla Bio has published validation data for its tissue-specific extracellular vesicle platform, built on NEXPLOR technology. Read more
14 Oct 2026 | Molecular Diagnostics

Image: The acquisition of Proscia advances Agilent’s efforts to expand its pathology portfolio and strengthens its competitive position in a rapidly growing market.

Agilent Acquisition of Proscia to Advance AI-Enabled Digital Pathology Workflows

Agilent Technologies has entered into a definitive agreement to acquire Proscia, a provider of digital pathology software for clinical and life-sciences customers. Read more
14 Oct 2026 | Industry

Image: Diazyme Laboratories has acquired Alfa Wassermann Diagnostic Technologies (AWDT), an FDA-registered manufacturer of chemistry systems and reagents, from CARR Biosystems

Diazyme Expands Chemistry Testing Portfolio With Alfa Wassermann Acquisition

Diazyme Laboratories, Inc. has acquired the business of Alfa Wassermann Diagnostic Technologies LLC from CARR Biosystems. Read more
14 Oct 2026 | Industry

Image: AISight Dx is a cloud-native digital pathology platform that streamlines case management, slide review, and collaboration to improve anatomic pathology workflows (Photo courtesy of PathAI)

Digital Pathology Collaboration Expands Laboratory Access to AI-Driven Diagnostics

An AI platform integration embeds digital pathology models into case workflows, expanding access to diagnostic decision support. Read more
14 Oct 2026 | Industry

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Clinical Chemistry

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Image Credit: iStock

Blood Protein May Help Identify Treatment-Resistant Psychosis

Psychotic disorders, including schizophrenia, are diagnosed primarily through assessment of symptoms and behaviors such as hallucinations, delusions, and disordered thinking. Treatment-resistant psychosis... Read more

Image: Schematic illustration of the operating principle of the enzyme-reaction-based highly sensitive biosensor (ESGNS) (Credit: Chihyun Kim, Wonjun Jo, Dayoung Chang, et al. Enzymatic sialylation–driven gold nanostructured platform for rapid and selective detection of sialic acid–deficient transferrin. Chemical Engineering Journal, 2026. https://doi.org/10.1016/j.cej.2026.182244)

Electrochemical Biosensor Rapidly Detects Cerebrospinal Fluid Leaks

Cerebrospinal fluid surrounds the brain and spinal cord and helps protect them from physical impact. After severe head trauma or brain surgery, it can leak through skull defects and drain from the nose or ears.... Read more

Blood Protein Panel Supports Monitoring of Treated Celiac Disease

Celiac disease is an autoimmune condition in which gluten triggers intestinal inflammation that can damage the gut and impair nutrient absorption. Even with a gluten-free diet, some patients may continue... Read more

Hemoglobin Levels May Help Signal Long-Term Dementia Risk

Dementia is a growing health challenge in aging societies, with limited treatment options and no cure. Identifying long-term risk remains difficult, particularly when specialist scans or emerging biomarkers... Read more

Molecular Diagnostics

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Image: GenomeNext uses a pangenome reference to better represent human genetic diversity and improve variant detection, while GenomeReveal integrates RNA analysis to help interpret certain DNA findings (Photo courtesy of Ambry Genetics)

Whole Genome Sequencing Solution Targets Unsolved Rare Disease Cases

Rare diseases often present persistent diagnostic challenges for patients and families. Many patients undergo years of testing without receiving a diagnosis, and even comprehensive genetic testing can... Read more

Study Shows How Genome Reference Bias Can Mislead Preventive Testing

Whole-genome sequencing is expected to play a growing role in preventive and predictive medicine, but accurate interpretation remains a major diagnostic challenge. The approach requires comparing billions... Read more

Validated Test Predicts Recurrence Risk and Radiation Benefit in Early-Stage Breast Cancer

For women with early-stage invasive breast cancer who undergo breast-conserving surgery, clinicians must assess both the risk of locoregional recurrence and the potential benefit of adjuvant radiation therapy.... Read more

Genomic Screening Expands Detection of Treatable Conditions in Newborns

Conventional newborn screening can miss conditions that lack biochemical biomarkers or present atypically. Initial hearing screens may also fail to detect hearing loss that is later identified through... Read more

Hematology

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Image Credit: Adobe Stock

New Donor Genetic Marker May Help Predict Stem Cell Transplant Success

Donor selection for hematopoietic stem cell transplantation plays a major role in relapse risk and survival for patients with blood cancers and other blood disorders. Despite advances in genotyping, uncertainty... Read more

Image Credit: American Society of Hematology

Updated Ferritin Thresholds Improve Detection of Iron Deficiency

Iron deficiency is one of the most common health conditions worldwide, yet its nonspecific symptoms can delay diagnosis for months. Variation in testing practices and ferritin thresholds may contribute... Read more

New Automated Hemostasis Systems Become Available Across US Laboratories

Hemostasis testing supports critical decisions in surgery, anticoagulation management, and the evaluation of bleeding and thrombotic disorders, but laboratories continue to face rising volumes and complex... Read more

Image: Acute myeloid leukemia is an aggressive blood cancer in which relapse remains a major challenge, making MRD detection critical for risk assessment and treatment planning (Image Credit: Shutterstock)

Variation in AML Residual Disease Testing Prompts Push for Standardization

Acute myeloid leukemia (AML) is an aggressive blood cancer in which relapse after therapy remains a persistent challenge, making measurable residual disease (MRD) detection central to risk assessment and... Read more

Immunology

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FDA Approval Adds Automated Testing Option for Parvovirus B19 Serology

Human Parvovirus B19 is a highly contagious erythrovirus transmitted mainly through respiratory droplets and close contact. Diagnosis relies on IgM antibodies to detect active infection and IgG antibodies... Read more

Blood-Based Immune Aging Map Could Help Spot Disease Risk Earlier

Chronological age does not always reflect immune health or future disease risk. Two adults of the same age can have immune systems that age very differently, with some remaining resilient while others... Read more

Blood-Based Immune Signal Could Reveal Lung Cancer Risk Before Tumors Develop

Lung cancer remains difficult to detect before symptoms appear, when advanced disease is harder to treat. In the U.K., about 32,800 people die from lung cancer each year, and only 11.1% of those diagnosed... Read more

Prototype Point-of-Care Test Aims to Improve Neonatal Sepsis Diagnosis

Neonatal sepsis remains difficult to diagnose because early signs can resemble other newborn conditions. Diagnostic delays may increase the risk of complications, death, long-term adverse outcomes, and... Read more

Microbiology

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Oral and Lung Microbiome Changes Linked to Severe Long Covid Symptoms

Long Covid can involve persistent respiratory, cognitive, and gastrointestinal symptoms after acute infection, creating a difficult diagnostic and management challenge. Because COVID-19 initially affects... Read more

Image: A health worker from the Mfou District Hospital collects a blood sample for the study (Photo courtesy of Sandrine Nsango, PhD)

Study Finds Distinct Malaria Parasites Linked to Sickle Cell Trait Protection

Malaria remains one of the world’s deadliest infectious diseases and has affected humans throughout recorded history. In regions where malaria is common, human genetics have been shaped by the sickle cell... Read more

Rapid Urine Test Aids Diagnosis of Invasive Aspergillosis

Invasive aspergillosis is an uncommon mold infection in the general population but can pose serious risks for people with weakened immune defenses. Diagnosis can be difficult because existing approaches... Read more

Image: Schematic overview of the CRISPR-Assisted Nanodroplet-pairing Platform for Differential Identification of NTM (CANDI). The platform combines broad-range amplification using conserved regions of the 16S and 23S rRNA genes with species-specific CRISPR recognition. Fluorescence-coded CRISPR droplets are paired with sample droplets containing amplified products, enabling multiplexed target recognition and signal decoding (Image Credit: Yiwen Yang, Jingsong Xu, Dakang Xu)

Nanodroplet CRISPR Technology Supports Rapid, Multiplexed Mycobacterial Identification

Mycobacterial infections are difficult to diagnose because closely related species can have different clinical and therapeutic implications. Nontuberculous mycobacteria (NTM) are increasingly recognized... Read more

Pathology

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Updated Digital Pathology Platform Expands AI Integration for Cancer Diagnosis

Digital pathology is reshaping how laboratories manage case review, image analysis, and collaboration. As diagnostic workflows become more complex, pathology teams need platforms that can support digital... Read more

Image: Overview of the multiple-instance learning (MIL) workflow, in which each TMA core image is represented as a bag of patches that are encoded and aggregated to generate a slide-level prediction. (Giner F, Pastor-Naranjo Á, Meseguer P, et al. International Journal of Molecular Sciences, 2026. DOI: 10.3390/ijms27156864)

AI Histopathology Tool Distinguishes Ewing Sarcoma for Diagnosis

Ewing sarcoma is a rare malignant tumor that mainly affects children, adolescents, and young adults. It usually arises in bone but can also develop in soft tissue, where its microscopic appearance may... Read more

Rapid Mass Spectrometry Test May Aid Glioma Margin Decisions

Glioma brain tumors are highly infiltrative and can extend into nearby healthy brain tissue, making tumor margins difficult to define during surgery. Residual tumor cells may contribute to recurrence and... Read more

Genomic Classifier Predicts Benefit From Adding Hormone Therapy to Salvage Prostate Radiation

Men who have undergone prostatectomy for prostate cancer may later develop a detectable or rising prostate-specific antigen, prompting salvage radiation therapy. A key challenge is determining who is most... Read more

Technology

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Laser-Based Swab Analysis Shows Promise for Detecting Disease-Linked Odor Patterns

Disease-related changes in volatile organic compounds can alter body odor, producing measurable patterns in exhaled breath and bodily fluids. Current analytical methods can be complex, time-consuming,... Read more

Image: Antibody-coated microscopic beads are introduced into a tiny flow channel containing blood plasma. Laser irradiation enhances their interaction with CEACAM-5, a colorectal cancer biomarker, causing the beads to assemble and generate a detectable signal. (Image Credit: Figure reproduced from Iida et al., Nanoscale Horizons(2026), DOI: 10.1039/d6nh00017g. Licensed under CC BY-NC 4.0.)

Laser-Enhanced Assay Boosts Sensitivity for Colorectal Cancer Biomarker Detection

Colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer-related death worldwide. Early detection remains critical, but cancer biomarkers can produce only faint... Read more

$Image: OGT\'s SureSeq next‑generation sequencing portfolio, designed for use with the Hamilton NGS STAR Line (Photo courtesy of Hamilton Company)$

New Automation Workflow Streamlines NGS Library Preparation for High-Volume Labs

Demand for next-generation sequencing (NGS) continues to rise as laboratories process growing sample volumes, yet library preparation remains labor-intensive and a frequent source of variability.... Read more

Image: ADLM recommends that emerging AI tools follow the same professional oversight, quality, validation, and monitoring standards as traditional clinical testing within CLIA’s existing framework (Image Credit: Adobe Stock)

ADLM Calls for CLIA Updates to Support Safe AI Use in Laboratory Medicine

Clinical laboratories increasingly use artificial intelligence to verify, interpret, and report results, but safeguards under the Clinical Laboratory Improvement Amendments (CLIA) were designed in 1992.... Read more

Industry

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$Image: Natera\'s MCED assay analyzes cell-free DNA in blood to screen for multiple cancers (Image Credit: Adobe Stock)$

Multi-Cancer Screening Blood Test Gains FDA Breakthrough Designation

Natera Inc.’s (Austin, TX, USA) multi-cancer early detection (MCED) assay has received Breakthrough Device designation (BDD) from the U.S. Food and Drug Administration (FDA). The assay analyzes cell-free... Read more

European Approval Expands Liquid Biopsy Use in Advanced Breast Cancer Testing

Estrogen receptor-positive (ER+), HER2-negative advanced breast cancer may require molecular testing to guide treatment selection, with blood-based assays offering a way to identify tumor mutations that... Read more

Regulatory Milestone Expands Access to Blood-Based Neurology Biomarker Testing in China

Quanterix Corporation (Billerica, MA, USA) and Innovita Biological Technology Co., Ltd. (Beijing, China) announced regulatory approvals that expand access to Quanterix SIMOA technology and neurology biomarker... Read more

Collaboration Advances Automated Benchtop Platform for Routine Blood Testing

Routine blood testing is central to clinical decision-making, but access can vary across laboratory and healthcare settings. Broader use of automated benchtop platforms may help integrate testing more... Read more

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