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Image: The approach aims to complement symptom-based clinical assessments for psychosis with quantifiable molecular readouts (photo courtesy of Shutterstock)

Blood-Based Biomarkers Show Promise for Psychosis Risk Prediction

Psychosis commonly emerges in adolescence or early adulthood and can severely disrupt social and occupational functioning. Read more
22 May 2026 | Clinical Chem.
Image: A member of the WHO Ebola ring vaccination team vaccinates a man in Bosolo village during a 2018 Ebola outbreak in Congo (Photo courtesy of WHO/Lindsay Mackenzie)

Diagnostic Gaps Complicate Bundibugyo Ebola Outbreak Response in Congo

In eastern Democratic Republic of the Congo, communities are confronting a resurgence of Bundibugyo ebolavirus, a rarer species for which no vaccines or treatments have been approved. Read more
21 May 2026 | Microbiology
Image: The new Guardant360 Liquid CDx assay measures a 100‑fold wider genomic footprint than the previously approved Guardant360 CDx (Photo courtesy of Guardant Health)

FDA Approves Expanded Liquid Biopsy Panel for Advanced Cancer Profiling

Timely, comprehensive tumor profiling helps clinicians make treatment selection decisions for patients with advanced cancer. Read more
21 May 2026 | Molecular Diagnostics
Image: QIA Agent is an AI-powered digital assistant designed to help users plan experiments, identify suitable products, access technical information, and manage ordering through a single interface (Photo courtesy of Qiagen)

AI-Enabled Assistant Unifies Molecular Workflow Planning and Support

Clinical laboratories and research groups face increasingly complex molecular workflows and expanding technical documentation spread across multiple systems. Read more
21 May 2026 | Technology
Image: The initiative will generate long‑read bulk RNA‑sequencing datasets to advance patient‑level prediction from tumor transcriptomes and support applications in biomarkers, clinical trial design, and diagnostics (Image courtesy of BlankBio)

Strategic Collaboration Advances RNA Foundation Models for Precision Oncology

Bulk RNA sequencing is increasingly used to study tumor biology, but standard analyses often reduce results to gene-level summaries that miss important transcript variants and mutation patterns. Read more
21 May 2026 | Industry
Image: The approach profiles bacteria in saliva and applies machine-learning algorithms to distinguish patients with ESCC from unaffected controls (image credit: Adobe Stock)

Microbial Saliva Test Could Help Triage Esophageal Cancer Risk

Esophageal squamous cell carcinoma (ESCC) is highly lethal, partly because many patients are diagnosed only after swallowing becomes difficult and treatment options are largely palliative. Read more
21 May 2026 | Molecular Diagnostics
Image: McGill researchers identified a centuries-old “jumping gene” mutation that helps explain elevated pancreatic cancer risk among some French-Canadians in Quebec (image credit: 123RF)

Hidden 'Jumping Gene' Variant Linked to Higher Pancreatic Cancer Risk

Pancreatic cancer risk among some French-Canadians in Quebec has been difficult to explain, as conventional genetic workups have often failed to identify inherited drivers. Read more
21 May 2026 | BioResearch
Image: The novel blood test could replace invasive biopsies for detecting acute cellular rejection after lung transplantation (image credit: 123RF)

Simple Blood Test Could Replace Biopsies for Lung Transplant Rejection Monitoring

Lung transplant recipients face some of the highest rates of acute cellular rejection, and routine surveillance often relies on repeated surgical biopsies. Read more
20 May 2026 | Immunology
Image: The original Yourgene DPYD test has been enhanced to detect 19 variants, including 14 recommended by updated guidelines and five additional variants for broader global coverage (photo courtesy of Yourgene Health)

Expanded DPYD Genotyping Test Supports Safer Chemotherapy Dosing

Fluoropyrimidines such as 5-fluorouracil (5-FU) are chemotherapy drugs prescribed to more than two million cancer patients each year, but 10–20% of patients can experience severe, and sometimes fatal, toxicities associated with dihydropyrimidine dehydrogenase (DPD) deficiency. Read more
20 May 2026 | Molecular Diagnostics
Image: Gustave Roussy is partnering with One Biosciences, a techbio company using single-cell technology and AI to advance precision diagnostics

Partnership Brings Single-Cell Analysis into Clinical Oncology Workflows

Selecting treatments for advanced cancer remains difficult when bulk analyses mask the functional diversity of tumor cells and mechanisms of resistance that emerge over time. Read more
20 May 2026 | Industry
Image: The integrated multi-omics approach may help identify bladder cancer patients likely to respond to BCG and those needing alternative or intensified treatment (image credit: iStock)

Multi-Omics Profiling Helps Predict BCG Response and Recurrence in Bladder Cancer

High-risk non–muscle-invasive bladder cancer frequently recurs after therapy, with about 30% of patients relapsing and roughly 10% dying within two years despite tumor resection, surveillance, and Bacillus Calmette-Guérin (BCG) immunotherapy. Read more
20 May 2026 | Molecular Diagnostics
Image: Investigators identify neutrophils as a newly recognized source of C4A, a protein genetically linked to schizophrenia (Photo courtesy of Dr Graham Beards/Wikimedia Commons, CC BY-SA 3.0)

Common White Blood Cells Produce Schizophrenia-Linked Protein

Schizophrenia affects about one in 100 people worldwide and is characterized by hallucinations, delusions, and substantial cognitive impairment. Read more
20 May 2026 | BioResearch
Image: For decades, laboratories have adjusted total calcium for albumin, but growing evidence shows these corrections often perform poorly and may cause harm (image credit: iStock)

International Experts Recommend Ending Routine 'Corrected' Calcium Reporting

Interpreting serum calcium can be clinically challenging when albumin levels vary, especially in patients with chronic illness or kidney disease. Read more
20 May 2026 | Clinical Chem.
Image: A novel computational tool can accurately identify RFC1 genetic changes linked to certain forms of peripheral neuropathy (photo courtesy of Adobe Stock)

New Computational Tool Reveals Genetic Driver of Idiopathic Neuropathy

Peripheral neuropathy is a common neurological disorder that causes pain, sensory loss, imbalance, and weakness, affecting an estimated 12%–20% of people in the U. Read more
20 May 2026 | Molecular Diagnostics

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Clinical Chemistry

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Urine-Based Nanosensor Tracks Lung Cancer and Fibrosis Noninvasively
Blood-Based Alzheimer’s Test Gains CE Mark for Amyloid Pathology Detection
FDA-Cleared Assay Enables Comprehensive Automated Testosterone Testing
Image: An updated review finds that prostate cancer blood tests likely reduce the risk of death, revising earlier findings that evidence was insufficient (photo courtesy of iStock)

Long-Term Data Show PSA Screening Modestly Reduces Prostate Cancer Deaths

Prostate cancer is among the most common cancers in men, and the role of population screening has remained controversial because of overdiagnosis and overtreatment. Health systems have sought clearer,... Read more

Molecular Diagnostics

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Whole-Genome MRD Test Detects Early Recurrence in Muscle-Invasive Bladder Cancer
Blood Test Detects Early Nonresponse in Metastatic Prostate Cancer
FDA-Cleared Genomic Profiling Assay Guides Treatment Selection in Solid Tumors
Image: Researchers identified eight new DNA pattern signatures that could help refine diagnostics and guide targeted therapy in breast cancer (image credit: 123RF)

Breast Cancer-Specific Signatures Link Genome Instability to Outcomes

Genomic instability is a hallmark of cancer, but most genomic analyses have relied on broad signatures shared across multiple malignancies, limiting their precision for individual tumor types.... Read more

Hematology

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Advanced CBC-Derived Indices Integrated into Hematology Platforms
Blood Test Enables Early Detection of Multiple Myeloma Relapse
Single Assay Enables Rapid HLA and ABO Genotyping for Transplant Matching
Image: Graphical abstract (Waclawiczek A, Leppä AM, Renders S, et al. Cell Stem Cell, 2026. doi:10.1016/j.stem.2026.04.012)

Stem Cell Biomarkers May Guide Precision Treatment in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is an aggressive blood cancer that most often affects older adults and still carries a poor prognosis despite therapeutic advances. Venetoclax-based regimens have improved... Read more

Immunology

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Biomarkers and Molecular Testing Advance Precision Allergy Care
Point-of-Care Tests Could Expand Access to Mpox Diagnosis
T-Cell Senescence Profiling May Predict CAR T Responses
Image: The findings suggest IGRA control responses offer a scalable measure of immune function from a widely used clinical assay (image credit: Adobe Stock)

Routine TB Screening Test May Reveal Immune Aging and Mortality Risk

Immune aging is associated with weaker responses to vaccination, greater risks of infection, and higher levels of inflammation. Leveraging routinely ordered laboratory tests to quantify that responsiveness... Read more

Microbiology

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Large-Scale Genomic Surveillance Tracks Resistant Bacteria Across European Hospi...
Molecular Urine and Stool Tests Do Not Improve Early TB Treatment in Hospitalized...
Rapid Antigen Biosensor Detects Active Tuberculosis in One Hour
Image: The findings suggest that people with mpox can transmit the virus even without clinical symptoms (image credit: Adobe Stock)

Study Finds Hidden Mpox Infections May Drive Ongoing Spread

Mpox continues to circulate despite vaccination, and many cases show no known link to a symptomatic partner. The role of people without symptoms has remained uncertain, limiting clarity on how transmission persists.... Read more

Pathology

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AI Pathology Test Receives FDA Breakthrough for Bladder Cancer Risk Stratificati...
FDA Clears AI Digital Pathology Tool for Breast Cancer Risk Stratification
New AI Tool Reveals Hidden Genetic Signals in Routine H&E Slides
Image: Graphical Abstract (Eldad D. Shulman et al., AI-predicted spatial transcriptomics unlocks breast cancer biomarkers from pathology, Cell (2026). DOI: 10.1016/j.cell.2026.04.023)

Rapid AI Tool Predicts Cancer Spatial Gene Expression from Pathology Images

Gene expression profiling can inform tumor biology and treatment selection, but spatial assays remain costly and time-consuming. Results can take weeks and cost thousands of dollars, limiting large-scale... Read more

Technology

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Point-of-Care Testing Enhances Health Literacy and Self-Management in Chronic Di...
Fully Automated Sample-to-Insight Workflow Advances Latent TB Testing
Tumor-on-a-Chip Platform Models Pancreatic Cancer Treatment Response
Image: Labbit is a modern LIMS platform designed for regulated laboratories managing complex workflows in molecular diagnostics, cell and gene therapy, and quality control manufacturing (photo courtesy of Labbit)

AI Tool Automates Validation of Laboratory Software Configuration Changes

Regulated laboratories face heavy documentation and requalification demands when software configurations change, slowing improvements and discouraging beneficial updates. A new capability now automates... Read more

Industry

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Partnership Aims to Bring Risk-Guided CKD Care to Health Systems
Roche to Acquire PathAI for Up to $1.05 Billion to Strengthen AI Diagnostics Por...
FDA Clears Blood-Based Companion Diagnostic for Advanced Breast Cancer Therapy
Image: Ozelle Wins German Innovation Award Gold (photo courtesy of Ozelle)

AI-Powered Multi-Functional Analyzer Wins German Innovation Award

Hematology services are increasingly delivered across distributed care settings, where limited staffing and complex workflows can extend turnaround times. Advanced morphology review still often depends... Read more

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