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Image: Schematic illustration of high-throughput, continuous-flow, and multi-scale enrichment of viable MTCs and MTCCs from pleural effusion samples using cascaded inertial microfluidics (Zhu, Z., Ren, H., Zhang, Z. et al. Microsyst Nanoeng 12, 101 (2026). doi.org/10.1038/s41378-026-01235-y)

Label-Free Microfluidic Device Enriches Tumor Cells and Clusters from Pleural Effusions

Diagnosing malignancy from pleural effusion remains challenging because tumor cells are rare and clusters are easily disrupted during processing. Read more
24 Apr 2026 | Clinical Chem.
Image: The findings show that patients with tumors harboring active networks of cytotoxic T cells were more likely to benefit from treatment, whereas those with dense clusters of plasma cells were significantly less likely to respond (photo courtesy of Shutterstock)

Tumor Immune Structure Predicts Response to Immunotherapy in Melanoma

Many patients with advanced melanoma start on anti-PD-1 immunotherapy, but responses can wane or never develop. Read more
24 Apr 2026 | Pathology
Image: The device contains specific antibodies that capture the primary biomarker of pancreatic cancer. The binding of these antibodies alters the distribution of electrical charges on the electrode surface. The sensor then translates this variation into a measurable capacitance signal (photo courtesy of Gabriella Soares / IFSC-USP)

Rapid Biosensor Detects Pancreatic Cancer Biomarker for Early Detection

Pancreatic cancer is frequently identified only after it has progressed because early disease is typically asymptomatic, and survival remains extremely poor once advanced. Read more
24 Apr 2026 | Clinical Chem.
Image: The PRET system provides an integrated solution for multiple pathology diagnostic tasks, including cancer screening, tumor subtyping, tumor segmentation, and lymph node metastasis detection (Li, Y., Ning, Z., Xiang, T. et al. Nature Cancer (2026). doi.org/10.1038/s43018-026-01141-2)

Plug-and-Play AI Pathology System Classifies Multiple Cancers from Few Slides

Pathologists are essential for cancer diagnosis and treatment planning, yet a global workforce shortage is straining services. Read more
23 Apr 2026 | Pathology
Image: Graphical abstract (Huang, A. Y. et al., Cell (2026). DOI: 10.1016/j.cell.2026.03.040)

Cancer-Related Mutations in Immune Cells Linked to Alzheimer’s

Alzheimer’s disease is marked by protein aggregation and inflammatory changes in the brain’s immune system, yet its molecular drivers remain incompletely understood. Read more
23 Apr 2026 | Molecular Diagnostics
Image: Graphical abstract (Qin, Y. et al., Cell Rep Med 7: 102761 (2026). DOI: 10.1016/j.xcrm.2026.102761)

Oral–Gut Microbiome Signatures Identify Early Gastric Cancer

Early detection of gastric cancer could be advanced by scalable screening strategies using minimally invasive sampling. Read more
23 Apr 2026 | Microbiology
Image: Artera’s multi-modal AI platform analyzes digital pathology and clinical data to support personalized cancer management (photo courtesy of Artera)

AI-Based Assays Support Risk Stratification in Prostate and Breast Cancer

Prostate and breast cancers are among the most commonly diagnosed malignancies worldwide, and heterogeneous disease biology complicates risk stratification and treatment selection. Read more
23 Apr 2026 | Pathology
Image: Magnetic field-enhanced alignment and detection of hemozoin in lysed infected red blood cells using polarizing microscopy (photo courtesy of Dickson Mwenda Kinyua, Kirinyaga University)

Label-Free Microscopy Methodd Enables Faster, Quantitative Detection of Malaria

Microscopy of blood smears remains a cornerstone for malaria diagnosis but can be slow, stain-dependent, and operator intensive. Read more
23 Apr 2026 | Microbiology
Image: Uppsala University researchers Ivaylo Stoimenov, Katarina Larsson and Tobias Sjöblom have identified biomarkers that could form the basis for tests capable of detecting cancer (photo courtesy of Mikael Wallerstedt)

Composite Blood Biomarkers Enable Early Detection of Common Cancers

Early diagnosis of colorectal, lung, and ovarian cancers remains challenging, with many patients identified only after tumors have begun to spread. Read more
23 Apr 2026 | Molecular Diagnostics
Image

Single Assay Enables Rapid HLA and ABO Genotyping for Transplant Matching

CareDx (Brisbane, CA, USA) has introduced AlloSeq Nano, a nanopore‑based HLA (human leukocyte antigen) and ABO genotyping solution unveiled at the European Federation for Immunogenetics (EFI) Conference 2026. Read more
23 Apr 2026 | Hematology
Image: Graphical abstract (Usyk M., Hayes R., Knight R. et al., Cell (2026). DOI: 10.1016/j.cell.2026.03.041)

Gut Microbiome Test Predicts Melanoma Recurrence After Surgery

Melanoma remains prone to relapse even after surgery and adjuvant immunotherapy, with 25% to 40% of patients experiencing recurrence. Read more
22 Apr 2026 | Microbiology
Image: The model analyzes routinely collected pathology slides to detect complex tissue features associated with immunotherapy response in metastatic NSCLC (photo courtesy of Shutterstock)

AI Pathology Model Predicts Immunotherapy Response in Lung Cancer

Clinicians face persistent challenges identifying which patients with metastatic non-small cell lung cancer will benefit from immunotherapy, even as these agents transform oncology care. Read more
22 Apr 2026 | Pathology
Image: Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma and often presents with aggressive clinical behavior (photo courtesy of Shutterstock)

Prognostic Biomarker Identified in Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma and often presents with aggressive clinical behavior. Read more
22 Apr 2026 | Hematology
Image: The new approach focuses on CpG DNA methylation, a chemical modification of cytosine and guanine bases, using tumor samples to develop a computational model that distinguishes among 21 cancer types (photo credet: 123RF)

Machine Learning Model Uses DNA Methylation to Predict Tumor Origin in Cancers of Unknown Primary

Cancers of unknown primary (CUP) are metastatic malignancies in which the primary site cannot be identified, complicating treatment selection. Read more
21 Apr 2026 | Molecular Diagnostics

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Clinical Chemistry

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Blood Test Predicts Alzheimer Disease Risk Before Imaging Changes and Symptoms
Study Finds ApoB Testing More Effective Than LDL for Guiding Lipid Therapy
AI-Enabled POC Test Quantifies Multiple Cardiac Biomarkers
Photo courtesy of Adobe Stock

Urine-Based Multi-Cancer Screening Test Receives FDA Breakthrough Device Designation

Early detection across multiple cancers remains a major unmet need in population screening. Non-invasive approaches that can be delivered at scale may broaden access and shift diagnoses to earlier stages.... Read more

Molecular Diagnostics

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Multi-Biomarker Blood Test Detects Early-Stage Cancers Across Types
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Framework Guides Targeted Immunotherapy Selection in Liver Cancer
Image: Graphical abstract (Robinson S, Haile B, Reily-Bell M et al, Cell Reports Medicine (2026). DOI: 10.1016/j.xcrm.2026.102744)

Blood Test Enables Early Detection and Classification of Glioma

High-grade gliomas, particularly glioblastoma, are fast-growing brain tumors that are often diagnosed late and typically require invasive procedures for confirmation. Current pathways rely on symptoms,... Read more

Hematology

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Prognostic Tool Guides Personalized Treatment in Rare Blood Cancer
New Platelet Function Assay Enables Monitoring of Antiplatelet Therapy
Open Multi-Omics Platform Identifies Prognostic Subtypes in Blood Cancers
Image: The findings suggest anemia may signal underlying disease, with routine blood tests helping identify patients needing closer follow-up (photo courtesy of 123RF)

Routine Blood Test Parameters Link Anemia to Cancer Risk and Mortality

Anemia detected in routine care can signal underlying pathology and is frequently encountered in adults. Because it is defined by hemoglobin levels below the normal range, it is often evaluated with red... Read more

Immunology

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Study Finds Influenza Often Undiagnosed in Winter Deaths
Combined Screening Approach Identifies Early Leprosy Cases
Antibody Blood Test Identifies Active TB and Distinguishes Latent Infection
Image: Graphical abstract - Human immune aging clock identifies RUNX1 as a decelerator of T cell senescence (photo courtesy of Zhang Weiqi)

Immune Aging Clock Quantifies Immunosenescence and Identifies Therapeutic Target

Immune aging undermines host defense and contributes to multiple age-related diseases, yet its heterogeneity complicates measurement and intervention. Clinical laboratories increasingly seek objective... Read more

Microbiology

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Antibiotic Resistance Genes Found in Newborns Within Hours of Birth
mNGS CSF Test Identifies CNS Pathogens Missed by Standard Panels
Rapid Color Test Stratifies Virulent and Resistant Staph Strains
Image: ASTar is a fully automated instrument designed to produce rapid phenotypic antibiotic susceptibility testing (AST) results directly from positive blood cultures in approximately six hours (photo courtesy of Q-Linea AB)

Rapid Blood-Culture Susceptibility Panel Expands Coverage for Gram-Negative Infections

Gram-negative bloodstream infections and sepsis demand fast, precise antimicrobial therapy, yet conventional susceptibility workflows can delay targeted treatment. Clinical laboratories need platforms... Read more

Pathology

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Study Reveals Moleclar Mechanism Driving Aggressive Skin Cancer
Biomarker Predicts Immunotherapy Response and Prognosis in Colorectal Cancer
Collaboration Applies AI Pathology to Predict Response to Antibody-Drug Conjugat...
Image: Laboratories can access Waiv’s tests via the Destra platform or integrate them into existing workflows through compatible IMS and viewer systems (photo courtesy of Waiv)

AI Precision Tests Deliver Cancer Risk Insights from Routine H&E Slides

Reliable prognostic profiling and biomarker screening are essential to guide oncology treatment decisions, while laboratories must balance speed and resource constraints. Earlier identification of high‑risk... Read more

Technology

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Integrated System Streamlines Pre-Analytical Workflow for Molecular Testing
Noninvasive Sputum Test Detects Early Lung Cancer
New AI Tool Enables Rapid Treatment Selection in Pediatric Leukemia
Image: Flow chart summarizing workflow pipeline (Thomas, V., Nyamundanda, G., Lärkeryd, A. et al. Sci Rep 16, 8843 (2026). https://doi.org/10.1038/s41598-026-39189-w)

AI Tool Predicts Non-Response to Targeted Therapy in Colorectal Cancer

Advanced bowel cancer remains difficult to treat, and many patients receive targeted therapies that do not help them but still cause harm. Clinicians need reliable ways to identify likely responders before... Read more

Industry

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Seegene Showcases Real-Time PCR Data Analytics Platform at ESCMID
Roche Affiliate Expands MRD Portfolio with SAGA Acquisition
Partnership Expands Ultrasensitive WGS Assay for for Hematologic Malignancies and...
Image: The acquisition adds the LEX VELO System to QuidelOrtho’s portfolio (photo courtesy of LEX Diagnostics)

QuidelOrtho Adds Ultra-Fast PCR Platform with LEX Acquisition

QuidelOrtho Corporation has completed the acquisition of LEX Diagnostics for approximately USD 100 million in cash. The transaction adds the LEX VELO System to QuidelOrtho’s portfolio. The platform received U.... Read more

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