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In Other News

Image: CareDx entered an agreement to acquire Naveris for $160 million upfront, with up to $100 million in additional milestone payments.

CareDx Expands Precision Oncology Portfolio with Naveris Acquisition

CareDx Inc. (Brisbane, CA, USA), a precision medicine company advancing clinically differentiated, high-value healthcare solutions for transplant patients and caregivers, has entered a definitive agreement to acquire Naveris (Waltham, MA, USA). Read more
29 Apr 2026 | Industry
Image: The indices are presented through intuitive software on the Aquila, Aquarius 3, and Abacus 5 analyzers (photo courtesy of Diatron)

Advanced CBC-Derived Indices Integrated into Hematology Platforms

Diatron, a STRATEC brand, has introduced six advanced hematological indices on its Aquila, Aquarius 3, and Abacus 5 hematology analyzers. Read more
29 Apr 2026 | Hematology
Image: Thermo Fisher expects the transaction with Astorg to close in the second half of 2026

Thermo Fisher Scientific to Sell Microbiology Business to Astorg

Thermo Fisher Scientific has signed a definitive agreement to sell its microbiology business to Astorg for approximately $1. Read more
29 Apr 2026 | Industry
Image: A nine‑protein plasma panel that estimates the likelihood of kidney disease progression in APOL1 high‑risk individuals (photo credit: Shutterstock)

Proteomic Risk Score Predicts Kidney Disease Progression in High-Risk Patients

Chronic kidney disease progression is difficult to anticipate, limiting opportunities to intervene before irreversible decline. Read more
29 Apr 2026 | Molecular Diagnostics
Image: EasyM is a highly sensitive blood-based test that traces a biomarker for myeloma called M-protein (photo credit: 123RF)

Blood Test Enables Early Detection of Multiple Myeloma Relapse

Bone marrow biopsies remain central to diagnosing and monitoring multiple myeloma, yet the procedure is painful, invasive, and often repeated over time. Read more
28 Apr 2026 | Hematology
Image: New findings underscore limitations of current two-tiered diagnostics in early Lyme Disease infection and point to a need for improved medical education on test interpretation (photo courtesy of Shutterstock)

Study Highlights Low Sensitivity of Current Lyme Tests in Early Infection

Accurate laboratory diagnosis of early Lyme disease remains challenging because serologic responses may be limited soon after infection. Read more
28 Apr 2026 | Immunology
Image: Reed-Sternberg cells are a hallmark of Hodgkin lymphoma and are found in affected lymph nodes (photo courtesy of Shutterstock)

New Molecular Insights Support Diagnosis of Hodgkin Lymphoma

Hodgkin lymphoma is the most common cancer in adolescents aged 15–19 and also affects adults over 55, typically presenting with enlarged lymph nodes. Read more
28 Apr 2026 | BioResearch
Image: Researchers identified a set of scalable, blood-based biomarkers associated with PTSD using common clinical laboratory tests (photo courtesy of Adobe Stock)

Routine Blood Tests Identify Biomarkers Linked to PTSD

Post-traumatic stress disorder (PTSD) is associated with a range of chronic physical health conditions and affects multiple organ systems. Read more
28 Apr 2026 | Clinical Chem.
Image: Graphical abstract (Jessica L. Corredor et al., The American Journal of Human Genetics (2026). DOI: 10.1016/j.ajhg.2026.03.014)

Risk Prediction Tool Enhances Genetic Testing for Li-Fraumeni Syndrome

Li-Fraumeni syndrome is a rare hereditary cancer predisposition most often driven by germline mutations in the TP53 tumor suppressor gene. Read more
28 Apr 2026 | Molecular Diagnostics
Image: The MechanoAge platform, shown here on a microscope stage, could be used to detect breast cancer risk. (Photo courtesy of Adam Lau/Berkeley Engineering)

Microfluidic Single-Cell Assay Predicts Breast Cancer Risk

Risk stratification for breast cancer remains imprecise, as population-based models and breast density can over- or underestimate individual risk, potentially leading to over- or under-screening. Read more
27 Apr 2026 | Technology
Image: New research shows genomic data can identify which precancerous cells progress to myeloid leukemia in children with Down syndrome (photo courtesy of Shutterstock)

Genetic Signature Predicts Myeloid Leukemia Risk in Down Syndrome

Children with Down syndrome face a markedly increased risk of myeloid leukemia, yet early lesions and pre-cancerous cells can appear indistinguishable under the microscope. Read more
27 Apr 2026 | Molecular Diagnostics
Image: Myalgic encephalomyelitis (ME) presents with heterogeneous, multisystem symptoms and post-exertional malaise, with overlap with conditions like fibromyalgia complicating diagnosis (photo courtesy of Shutterstock)

Epigenetic Signals and Blood Markers Aid Chronic Fatigue Syndrome Diagnosis

Myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome, presents with heterogeneous symptoms and a hallmark of post‑exertional malaise that complicate clinical assessment. Read more
27 Apr 2026 | BioResearch
Image: Biosensor for tuberculosis detection (photo courtesy of UPV)

Rapid Antigen Biosensor Detects Active Tuberculosis in One Hour

Tuberculosis remains a major global health challenge and continues to drive significant morbidity and mortality. Read more
27 Apr 2026 | Microbiology
Photo courtesy of Adobe Stock

Gene Expression Model Guides Neoadjuvant Therapy Selection in Breast Cancer

Predicting which patients with early breast cancer will benefit from chemotherapy before surgery remains difficult. Read more
27 Apr 2026 | Molecular Diagnostics

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Clinical Chemistry

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Routine Blood Count Ratio Linked to Future Alzheimer’s and Dementia Risk
Label-Free Microfluidic Device Enriches Tumor Cells and Clusters from Pleural Ef...
Rapid Biosensor Detects Pancreatic Cancer Biomarker for Early Detection
Image: Study results show blood protein levels change markedly in childhood and adolescence, with sex differences increasing with age (photo credit: Adobe Stock)

Proteomic Data Underscore Need for Age-Specific Pediatric Reference Ranges

Serum proteins underpin many routine tests used to detect inflammation, hormonal imbalance, cardiovascular disease, and metabolic disorders. Yet pediatric interpretation often relies on adult reference... Read more

Molecular Diagnostics

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Cancer-Related Mutations in Immune Cells Linked to Alzheimer’s
Composite Blood Biomarkers Enable Early Detection of Common Cancers
Machine Learning Model Uses DNA Methylation to Predict Tumor Origin in Cancers of...
Image: Curve Biosciences’ Whole-Body Intelligence platform uses AI and the company's Whole-Body Atlas to uncover organ-specific biology from blood (photo courtesy of Curve Biosciences)

AI Blood Test Enhances Monitoring of Liver Cirrhosis Progression

Monitoring chronic liver disease remains difficult because clinicians rely on tools that can be inconsistent and may miss early progression. Standard approaches often combine ultrasound imaging with blood-based... Read more

Hematology

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Prognostic Biomarker Identified in Diffuse Large B-Cell Lymphoma
Routine Blood Test Parameters Link Anemia to Cancer Risk and Mortality
Prognostic Tool Guides Personalized Treatment in Rare Blood Cancer
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Single Assay Enables Rapid HLA and ABO Genotyping for Transplant Matching

CareDx (Brisbane, CA, USA) has introduced AlloSeq Nano, a nanopore‑based HLA (human leukocyte antigen) and ABO genotyping solution unveiled at the European Federation for Immunogenetics (EFI) Conference 2026.... Read more

Immunology

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Study Finds Influenza Often Undiagnosed in Winter Deaths
Combined Screening Approach Identifies Early Leprosy Cases
Antibody Blood Test Identifies Active TB and Distinguishes Latent Infection
Image: Graphical abstract - Human immune aging clock identifies RUNX1 as a decelerator of T cell senescence (photo courtesy of Zhang Weiqi)

Immune Aging Clock Quantifies Immunosenescence and Identifies Therapeutic Target

Immune aging undermines host defense and contributes to multiple age-related diseases, yet its heterogeneity complicates measurement and intervention. Clinical laboratories increasingly seek objective... Read more

Microbiology

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Label-Free Microscopy Methodd Enables Faster, Quantitative Detection of Malaria
Gut Microbiome Test Predicts Melanoma Recurrence After Surgery
Rapid Blood-Culture Susceptibility Panel Expands Coverage for Gram-Negative Infe...
Image: Graphical abstract (Qin, Y. et al., Cell Rep Med 7: 102761 (2026). DOI: 10.1016/j.xcrm.2026.102761)

Oral–Gut Microbiome Signatures Identify Early Gastric Cancer

Early detection of gastric cancer could be advanced by scalable screening strategies using minimally invasive sampling. Saliva collection is noninvasive and cost-effective, supporting wider adoption... Read more

Pathology

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Interpretable AI Reveals Hidden Cellular Features from Microscopy Images
Tumor Immune Structure Predicts Response to Immunotherapy in Melanoma
Plug-and-Play AI Pathology System Classifies Multiple Cancers from Few Slides
Image: Study flowchart. This study developed a multimodal artificial intelligence framework to predict PIK3CA mutations in breast cancer (Jiaxian Miao et al., Cancer Biol Med 23(3): 430–450 (2026). DOI: 10.20892/j.issn.2095-3941.2025.0771)

Multimodal AI Tool Predicts Genetic Alterations to Guide Breast Cancer Treatment

PIK3CA mutations are key biomarkers for selecting phosphoinositide 3-kinase (PI3K)–targeted therapies in breast cancer, yet access to molecular testing can be inconsistent and costly. Conventional polymerase... Read more

Technology

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Integrated System Streamlines Pre-Analytical Workflow for Molecular Testing
Noninvasive Sputum Test Detects Early Lung Cancer
New AI Tool Enables Rapid Treatment Selection in Pediatric Leukemia
Image: Flow chart summarizing workflow pipeline (Thomas, V., Nyamundanda, G., Lärkeryd, A. et al. Sci Rep 16, 8843 (2026). https://doi.org/10.1038/s41598-026-39189-w)

AI Tool Predicts Non-Response to Targeted Therapy in Colorectal Cancer

Advanced bowel cancer remains difficult to treat, and many patients receive targeted therapies that do not help them but still cause harm. Clinicians need reliable ways to identify likely responders before... Read more

Industry

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QuidelOrtho Adds Ultra-Fast PCR Platform with LEX Acquisition
Seegene Showcases Real-Time PCR Data Analytics Platform at ESCMID
Roche Affiliate Expands MRD Portfolio with SAGA Acquisition
Image: Karius Focus BAL is designed to quickly identify the etiology of lung infections and improve diagnostic yield over standard of care testing (Photo courtesy of Karius)

Collaboration Expands Access to Rapid Metagenomic Diagnostics for Complex Infections

Hospitals are seeing rising rates of complicated and healthcare-associated infections, especially in immunocompromised patients, intensifying the need for rapid, comprehensive pathogen detection.... Read more

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