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Image: Researchers use a novel immobilized liposome-bound gel beads method to measure CEC levels and their association with cardiovascular risks (Photo courtesy of Institute of Science Tokyo)

Simple Blood-Based Cholesterol Efflux Assay Identifies High-Risk Coronary Plaque Features

A new blood test measuring cholesterol efflux capacity flags vulnerable coronary plaque features, improving risk stratification. Read more
12 Jun 2026 | Clinical Chem.
Image: Overview of the uncertainty-aware lensfree computational pathology platform for automated HER2 assessment. A compact lensfree holographic imaging system captures diffraction patterns from immunohistochemically stained breast tissue samples, which are computationally reconstructed and analyzed using deep neural networks with Bayesian uncertainty quantification. (Photo courtesy of Ozcan Lab, UCLA)

Uncertainty-Aware AI Platform Supports Automated HER2 Assessment in Breast Cancer

An imaging and AI platform automates HER2 scoring and flags cases that may need further review,. Read more
12 Jun 2026 | Pathology
Image: Tempus will open source the Paige IMS, including its slide viewer, case management solution, and AI integration modules, providing a clinical-grade baseline platform for institutions worldwide (Photo courtesy of Tempus)

Open-Source Consortium Aims to Standardize Digital Pathology Workflows

A new open-source initiative now provides a clinical-grade platform and collaborative framework to advance standardization across institutions. Read more
11 Jun 2026 | Industry
Image: The new AI system classifies 102 molecular subtypes of CNS tumors from digitized, routinely stained histology sections (Image credit: iStock)

AI Tool Speeds Brain Tumor Classification from Routine Histology Slides

An AI approach classifies a wide range CNS tumor subtypes from routine slides in minutes. Read more
11 Jun 2026 | Pathology
Image: Used as a predictive biomarker, VENTANA MMR RxDx Panel helps identify cancer patients eligible for certain precision oncology therapies, with IVDR approval expanding the companion diagnostic’s label to five cancer types and six indication (Photo courtesy of Roche)

IHC Companion Diagnostic Standardizes Mismatch Repair Testing for Cancer Immunotherapy

An IVDR-approved immunohistochemistry panel standardizes mismatch repair testing and enables therapy selection across multiple solid tumors. Read more
11 Jun 2026 | Pathology
Image Credit: iStock

New Library Normalization and Amplification Tools Support Oncology Sequencing

New technologies support scalable library normalization and improved amplification accuracy for oncology sequencing. Read more
11 Jun 2026 | Molecular Diagnostics
Image: Three gray matter (GM) structural networks related to default mode network (DMN). Three GM structural networks related to DMN that were identified are shown. (A) anterior DMN; (B) posterior DMN-I, including the posterior cingulate cortex (PCC) and precuneus; and (C) posterior DMN-II, including the PCC, precuneus, inferior parietal cortex, and lateral temporal cortices. (Photo courtesy of Nagaya et al., 2026, PLOS One, CC-BY 4.0)

Plasma Vitamin C Levels Associated with Brain Structure and Connectivity in Aging

New data link plasma vitamin C to greater gray matter volume and stronger default mode network connectivity in older adults. Read more
11 Jun 2026 | Clinical Chem.
Image: The method can analyze samples containing about 5% cancer DNA, compared with the 15–20% typically required by current techniques. (Image Credit: iStock)

Statistical Method Improves Detection of Low-Level Cancer DNA in Blood Samples

A new blood-test analysis method detects tumor-related DNA changes even when cancer DNA levels are low. Read more
11 Jun 2026 | Molecular Diagnostics
Image: General workflow for liquid chromatography/mass spectrometry-based metabolomics (Rowles, J.L., Patti, G.J. Nature Reviews Cancer (2026). doi.org/10.1038/s41568-026-00908-0)

Mass Spectrometry Detects Tumor Metabolites for Cancer Monitoring

A mass spectrometry-based metabolomics and isotope tracer approach maps in vivo tumor fuel use to improve patient monitoring Read more
11 Jun 2026 | Clinical Chem.
Image: Development of an artificial intelligence method to accurately characterize mutations in liquid biopsies (Image Credit: Valsamo Anagnostou/ChatGPT)

AI Tool Improves Accuracy of Cancer Liquid Biopsy for Therapy Selection

An AI approach classifies mutation origin in liquid biopsy cfDNA filtering white blood cell noise and improving therapy selection. Read more
10 Jun 2026 | Molecular Diagnostics
Image: The TORCH complex includes pathogens that can cause mild or silent maternal infections yet lead to serious fetal complications, underscoring the need for better surveillance and prevention (photo courtesy of iStock)

TORCH Infection Trends Point to Need for Tailored Screening in Pregnancy

New data reveal persistent maternal-fetal TORCH risks in North India, supporting tailored screening and CMV-focused education. Read more
10 Jun 2026 | Microbiology
Image: The findings support genetic testing to guide screening and preventive care in young Black women with breast cancer (image credit: iStock)

Study Highlights Inherited Breast Cancer Risk Genes in Young Black Women

New data reveal BRCA1/BRCA2 variants predominate in early-onset breast cancer in Black women, supporting broader genetic testing. Read more
10 Jun 2026 | Molecular Diagnostics
Image: The study shows how targeted RNA analysis with Ambry’s ExomeReveal workflow can resolve uncertain findings and improve diagnostic clarity (Image Credit: iStock)

Targeted RNA Test Enhances Genetic Diagnosis in Exome Sequencing

A new targeted RNA analysis workflow demonstrates how uncertainty from exome testing can be reduced Read more
10 Jun 2026 | Molecular Diagnostics
Image: Findings demonstrate that AI can help classify meningiomas by extracting molecular and prognostic information from standard H&E slides already used in routine care. (Image Credit: Mikael Häggström, M.D./Wikimedia Commons, CC0 1.0)

AI Pathology Tool Predicts Meningioma Recurrence from Routine Slides

An AI approach reads routine H&E slides to classify meningiomas and predict recurrence. Read more
10 Jun 2026 | Pathology

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Saliva-Based Test Detects Biochemical Signs of Sleep Loss
Simple Dual-Tau Blood Test Detects and Stages Alzheimer’s Disease
Alzheimer’s Blood Biomarkers Linked to Early Cognitive Differences Before Dement...
Image: DNlite measures urinary post-translationally modified Fetuin-A (uPTM-FetA), a biomarker linked to kidney stress, inflammation, metabolic dysfunction, and progressive renal injury (Photo courtesy of Bio Preventive Medicine Corp)

Urinary Biomarker Assay Predicts Kidney Disease Progression Beyond Standard Measures

Many patients with type 2 diabetes and chronic kidney disease continue to experience progressive renal decline, yet conventional markers such as albuminuria and estimated glomerular filtration rate (eGFR)... Read more

Molecular Diagnostics

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Blood Test Predicts Immunotherapy Response in Head and Neck Cancer
New PCR Assay Supports Bundibugyo Ebola Outbreak Surveillance
Plasma Protein Signature Predicts Lung Cancer Risk Up to Five Years Ahead
Image: New findings connect ribosome stress biology with blood-based small RNA biomarkers, highlighting the potential of liquid biopsy for lung cancer patient stratification (Image credit: 123RF)

Blood-Based RNA Test May Predict Chemotherapy Sensitivity in Lung Cancer

Lung cancer care increasingly relies on biomarker-guided patient stratification, but tissue biopsy can be impractical and treatment selection remains difficult for many patients. Blood-based assays that... Read more

Hematology

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Blood Eosinophil Count May Predict Cancer Immunotherapy Response and Toxicity
Higher Ferritin Threshold May Improve Iron Deficiency Detection in Children
Stem Cell Biomarkers May Guide Precision Treatment in Acute Myeloid Leukemia
Image: Sysmex America’s next generation XR-Series, a hematology solution designed to help busy laboratories deliver fast, reliable results while maintaining efficient workflows (Photo courtesy of Sysmex America)

Next-Generation Hematology Platform Streamlines High-Complexity Lab Workflows

Sysmex America (Chicago, IL, USA) has introduced the next generation XR-Series, centered on the XR-10 Automated Hematology Module for high-complexity laboratories. The platform builds on the widely used... Read more

Immunology

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Study Points to Autoimmune Pathway Behind Long COVID Symptoms
Metabolic Biomarker Distinguishes Latent from Active Tuberculosis and Tracks Tre...
Immune Enzyme Linked to Treatment-Resistant Inflammatory Bowel Disease
Image: (A) Schematic illustration of the X-aptamer protein SELEX process for isolating aptamers. (B) Schematic illustration of the ultrasensitive detection of the SARS-CoV-2 N protein via the MD ELAAA platform. (Shu Zhou, Yuxi Xu, Huan Liao, et al. Genomics (2026). DOI: 10.1016/j.gendis.2025.101943)

Aptamer-Based Biosensor Enables Mutation-Resilient SARS-CoV-2 Detection

Rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can undermine existing molecular diagnostics, especially when assays target small viral components. Double-antibody sandwich... Read more

Microbiology

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Automated Blood Culture System Speeds Detection of Bloodstream Infections
Gut Microbiome Signatures Help Identify Risk of IBD Progression
FDA-Cleared Gastrointestinal Panel Detects 24 Pathogen Targets
Image: The modified culture medium speeds fidaxomicin resistance detection while reducing material and labor demands (image credit: Adobe Stock)

New Culture Medium Speeds C. difficile Resistance Detection and Reduces Costs

Clostridioides difficile infections remain a persistent threat in hospitals and communities, affecting about 500,000 people in the United States each year. Severe cases can be fatal within 30 days of diagnosis,... Read more

Pathology

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Blood-Based Method Tracks Gene Activity in the Living Brain
FDA Approval Expands Automated PD-L1 Testing Across Solid Tumors
AI-Powered Atlas Maps Immune Structures Linked to Cancer Outcomes
Image: The Deep Visual Spatial Transcriptomics and Proteomics (DVSTP) strategy integrates high-resolution pathology images with spatial transcriptomics and spatial proteomics to reveal the complex intra-tumor heterogeneity. DVSTP predicts molecular profiles from routine pathology slides, making spatial multi-omics more accessible. Whole–tumor 3D reconstruction reveals that SRSF6 drives immune exclusion and poor clinical outcomes (Photo courtesy of Science Bulletin)

3D Spatial Multi-Omics Maps Intra-Tumor Diversity in Colorectal Cancer

Colorectal cancer remains a leading cause of cancer death, and clinical decision-making is complicated by marked intra-tumor heterogeneity. Conventional bulk sequencing averages molecular signals across... Read more

Technology

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Agentic AI Platform Supports Genomic Decision-Making in Oncology
Mailed Screening Kits Help Reduce Colorectal Cancer Screening Gaps
Algorithm Panel Aids Liver Fibrosis Assessment and Liver Cancer Surveillance
Image: Foundation Medicine will launch advanced digital solutions integrated with Roche’s navify Clinical Hub to deliver personalized insights to U.S. providers at the point of care (Photo courtesy of Roche)

AI Platform Links Biomarker Results to Cancer Clinical Trials and Guidelines

Oncology teams must manage growing volumes of genomic data, rapidly evolving clinical trial options, and frequently updated care guidelines, all within tight clinic schedules. Translating complex tumor... Read more

Industry

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Collaboration Advances ctDNA-Guided Development in Metastatic Colorectal Cancer
Diazyme Laboratories Acquires Carolina Liquid Chemistries
Partnership Expands Access to Alzheimer’s Blood Tests in Latin America and Carib...
Image: Alpha-1 antitrypsin deficiency (ADD) is a progressive genetic condition, a major inherited risk factor for COPD, and a cause of liver disease in children and adults (Image credit: Adobe Stock)

Genetic Testing Program Expands Detection of Alpha-1 Antitrypsin Deficiency

Alpha-1 Antitrypsin Deficiency (AATD) is a progressive genetic condition, the leading known genetic risk factor for chronic obstructive pulmonary disease (COPD), and a cause of liver disease in both children... Read more

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