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Clinical Chemistry

Image: Primary central nervous system lymphoma (PCNSL) is a rare malignancy of the brain, spinal cord, and eyes that is often diagnosed late and associated with poor outcomes (Photo courtesy of Tdvorak / Wikimedia Commons / CC BY-SA 3.0)

Fluid Biomarker Improves Diagnosis and Monitoring of Primary CNS Lymphoma

A new study identifies a biomarker that could support earlier diagnosis of rare, aggressive brain and eye cancers. More...
26 May 2026
Image: New findings suggest that standard “normal” CA19-9 cutoffs may mask aggressive disease in nonproducers, while a dual-threshold model could reduce misinterpretation (image credit: Adobe Stock)

New CA19-9 Cutoff Value Helps Identify High-Risk Pancreatic Cancer Patients

New findings demonstrate that adopting a lower CA19-9 cutoff can better identify high-risk pancreatic cancer patients. More...
22 May 2026
Image: The approach aims to complement symptom-based clinical assessments for psychosis with quantifiable molecular readouts (photo courtesy of Shutterstock)

Blood-Based Biomarkers Show Promise for Psychosis Risk Prediction

An AI-guided blood proteomics approach predicts transition to psychosis in Asian youths with up to 96% accuracy. More...
22 May 2026
Image: For decades, laboratories have adjusted total calcium for albumin, but growing evidence shows these corrections often perform poorly and may cause harm (image credit: iStock)

International Experts Recommend Ending Routine 'Corrected' Calcium Reporting

Guidelines recommend ending routine albumin-adjusted calcium reporting and prioritizing ionized calcium for key decisions. More...
20 May 2026
Image: An updated review finds that prostate cancer blood tests likely reduce the risk of death, revising earlier findings that evidence was insufficient (photo courtesy of iStock)

Long-Term Data Show PSA Screening Modestly Reduces Prostate Cancer Deaths

New data show PSA screening modestly cuts prostate cancer deaths but increases detection of earlier-stage disease. More...
20 May 2026
Image: Originally designed for lung cancer detection and resistance monitoring, the test also shows potential for identifying signals linked to pulmonary fibrosis (image credit: iStock)

Urine-Based Nanosensor Tracks Lung Cancer and Fibrosis Noninvasively

A new urine test tracks enzyme activity to support earlier, ongoing monitoring of lung cancer and pulmonary fibrosis. More...
15 May 2026
Image: Roche’s CE-Marked Elecsys pTau217 blood test is a single‑assay blood test measures phosphorylated tau 217, an indicator of amyloid pathology and a hallmark of Alzheimer’s disease (image credit: Shutterstock)

Blood-Based Alzheimer’s Test Gains CE Mark for Amyloid Pathology Detection

A new test measures pTau217 to rule in or rule out amyloid pathology, enabling earlier, less invasive Alzheimer’s assessment. More...
14 May 2026
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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