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BioResearch

Image: New research shows that human lung cancers use a process called alternative RNA splicing to produce different versions (isoforms) of the immune-alarm gene STAT2, shown here as ribbons. Isoforms of STAT2 are associated with how well lung cancer patients respond to immunotherapy: an isoform that retains an extra segment called an intron (top ribbon) is found in patients who respond to anti-PD-L1, while an isoform without it (bottom ribbon) is found in nonresponders. These splicing signatures could one day help doctors predict, before treatment begins, which patients are most likely to benefit from immunotherapy. (Photo courtesy of The Jackson Laboratory)

Lung Tumor RNA Variants Offer Clues to Immunotherapy Benefit

Researchers identify gene activity patterns linked to immunotherapy response in lung cancer. More...
27 Oct 2026
Graphical abstract summarizing the key characteristics of the "average" genome, highlighting that variation is the norm. (Credit: Professor Caroline Wright, University of Exeter)

Population-Scale Genome Survey Supports Interpretation of Genetic Testing

New data from population-scale sequencing define the average genome, aiding clinical interpretation of disease-linked variants. More...
26 Oct 2026
Image: Spleen tissue from a mouse without PHF19 (left) and a mouse with normal PHF19 function (right). Dense clusters of immune cells sit within blood-rich regions in pink. Without PHF19, cells are altered in their differentiation process (Photo courtesy of Gianni Gamarra/Centro de Regulación Genómica)

Six-Gene Score Improves Prognosis Prediction in Acute Myeloid Leukemia

Researchers identify a six-gene AML score that more accurately predicts survival and may simplify prognostic testing. More...
25 Oct 2026
Image: Clinical single-cell profiling at diagnosis may help guide more personalized treatment for difficult-to-treat cancers. (Image Credit: Adobe Stock)

Single-Cell Profiling Reveals Chemotherapy Resistance Signals in Ovarian Cancer

Clinical single-cell profiling at diagnosis could help guide more personalized treatment strategies for difficult-to-treat cancers. More...
22 Oct 2026
Image: The newly released  RepX uses Electronic Genome Mapping (EGM) data generated on the OhmX Platform (Photo courtesy of Nabsys)

Genomic Tool Supports Analysis of Repeat Expansions Linked to Inherited Disorders

A newly launched analysis pipeline now uses electronic genome mapping data to investigate disease-associated repeat expansions More...
20 Oct 2026
Image: Cell culture of induced pluripotent stem cells (iPSCs). Neurons are shown in green and astrocytes in red. (Photo courtesy of Carlos Avilés Granados)

CSF Biomarker Meprin-Beta Increases in Alzheimer’s Disease

New findings show elevated active meprin-β in brain and CSF in Alzheimer’s disease, suggesting utility as a biomarker. More...
20 Oct 2026
Image: The discovery could enable early screening of young children, with the long-term goal of preventing pediatric cancers from developing later in childhood. (Image Credit: Shutterstock)

Blood Antibody Signals May Offer Clues to the Origins of Childhood Cancer

New findings identify blood-based immune markers that may flag increased childhood cancer risk years before diagnosis. More...
16 Oct 2026
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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