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Clinical Chemistry

Image: Photomicrograph of histology of fibrolamellar hepatocellular carcinoma, showing large polygonal tumors cells with granular eosinophilic cytoplasm (Photo courtesy of Nephron)

Marker Panel Detects Early Liver Cancer with Increased Sensitivity

 Several types of cancer can form in the liver. The most common type of liver cancer is hepatocellular carcinoma, which begins in the main type of liver cell (hepatocyte). Other types of liver cancer, such as intrahepatic cholangiocarcinoma and hepatoblastoma, are much less common. More...
05 Dec 2019
Image: The Quantum Access triple quadruple mass spectrometer (Photo courtesy of Thermo Scientific)

Blood Sphingolipidomics Associated with Lupus Cardiovascular Comorbidity

 Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with heterogeneous organ involvement and severity. The cause of SLE is unknown, and there is at present no cure. The majority of people with lupus are females, and African-American women are three times more likely than White women to have lupus and develop severe symptoms. More...
04 Dec 2019
Image: A cancer cell amongst normal cells. A new biomarker, plectin, has been discovered in cancer stem cells that governs cancer survival and spread (Photo courtesy of Laurie Fickman/ University of Houston).

New Biomarker Discovered for Cancer Stem Cells

 Tumors often contain a small subset of drug-resisting, self-renewing, and highly metastatic cells called tumor initiating cells or cancer stem cells (CSCs). These cells can self-renew, divide asymmetrically, and form tumors in isolation. More...
28 Nov 2019
Image: The Hepcidin-25 (bioactive) HS ELISA RUO is a highly sensitive enzyme immunoassay for the quantitative measurement of Hepcidin-25 in serum or plasma. Hepcidin is elevated in Parkinson’s disease patients (Photo courtesy of DRG Instruments)

Uremic Toxins Level Measured in Parkinson’s Disease Patients

 Uremic-retention solutes are the compounds whose concentration in an organism increases with decreasing kidney function. At uremic concentrations, they play a crucial role in the progression of chronic kidney diseases (CKD) and have negative outcomes. More...
27 Nov 2019
Image: The cobas c 513 analyzer is a dedicated high throughput HbA1c analyzer designed to meet efficiency, throughput and accuracy needs for HbA1c laboratory testing (Photo courtesy of Roche Diagnostics)

Next Generation Glycated Hemoglobin Assay Evaluated

 Diabetes mellitus is a pathological condition that affects all age groups worldwide. The percentage of glycated hemoglobin A1C (HbA1C) reflects the mean plasma glucose level over the previous 3 to 4 months for most individuals and can be used to diagnose type 2 diabetes. More...
26 Nov 2019
Image: The Architect clinical chemistry autoanalyzer C16000 (Photo courtesy of Abbott Diagnostics).

Effect of Lipoprotein(A) on the Diagnosis of Familial Hypercholesterolemia

 The recent focus on familial hypercholesterolemia (FH) as a high-risk condition predisposing to premature coronary artery disease (CAD) has led to more widespread screening and diagnosis of the condition. Familial hypercholesterolemia is a genetic disorder. More...
25 Nov 2019
Image: The new ClinSpec Diagnostics’ test can diagnose brain cancer from a blood sample (Photo courtesy of University of Strathclyde).

Chemical Analysis of Blood Samples Diagnoses Brain Tumors

 Brain tumors tend to have ambiguous symptoms, such as headache or memory problems, and a brain scan is currently the only reliable way of diagnosing them. In recent years, the use of infrared (IR) spectroscopy to analyze disease state in biofluids has been largely employed with promising results. More...
21 Nov 2019
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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