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Clinical Chemistry

Image: The MAGPIX fluorescent-based analytical instrument (Photo courtesy of Luminex).

Biomarkers Panel Used for Pleural and Peritoneal Effusions Diagnosis

The quantification of biomarkers in cavity fluids may aid in the etiological diagnosis and in patients' management. Laboratory investigation of cavity effusions involves the evaluation of biochemical, immunological, microbiological, molecular and cellular parameters. More...
25 Sep 2019
Image: The IDS-iSYS fully automated immunoanalyser (Photo courtesy of IDS Nordic).

Bone and Cartilage Biomarkers Analyzed for Knee Osteoarthritis

Osteoarthritis (OA) is the most common arthritic disease, affecting more than 250 million people in the world. The disease is characterized by excessive cartilage degradation, abnormal bone growth and sclerosis and synovial inflammation in a subset of patients. More...
25 Sep 2019
Image: Nuclear magnetic resonance (NMR) spectroscopy estimated higher HDL-CEC is associated with a lower risk of coronary heart disease (CHD) (Photo courtesy of the University of Oulu).

New Method May Lower Costs Associated with HDL-CEC Measurements

Circulating high-density lipoprotein (HDL) particles mediate reverse cholesterol transport by carrying excess cholesterol from the periphery, such as the arterial wall, to the liver for excretion into the bile. HDL-mediated cholesterol efflux capacity is a functional attribute that may have a protective role in atherogenesis. More...
18 Sep 2019
Image: The TripleTOF 6600 Quadrupole Time-Of-Flight (QTOF) mass analyzer (Photo courtesy of Sciex).

Protein Panel Developed for Early Detection of Lung Cancer

Lung cancer is the most common cause of cancer-related mortality worldwide, characterized by late clinical presentation as 49%–53% of patients are diagnosed at stage IV, and consequently have poor outcomes. More...
18 Sep 2019
Image: Islet of Langerhans from the pancreas of a patient with chronic Type 1 diabetes of 19 years duration. A single lobe of the pancreas was found to contain islets rich in residual beta cells (alpha cells in red; beta cells in green) (Photo courtesy of Diapedia).

Biomarker Identified for Early Beta-Cell Death in Type 1 Diabetes

Beta cells in the pancreas produce insulin and their death is a key feature of Type 1 diabetes, and that loss starts long before diagnosis. However, there has been no straightforward way to measure that early loss. More...
18 Sep 2019
Image: The High Mobility Group Box protein 1 (HMGB1) quantitative enzyme-linked immunosorbent assay kit (Photo courtesy of Shino-Test Corporation).

Serum HMGB1 Levels Reflect Clinical Features of HLH

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome. Hypercytokinemia secreted from dysregulated hyperactivated monocytes, macrophages, T cells and NK cells has been reported to play a major role in HLH. More...
17 Sep 2019

Increased Risk of Hypoandrogenemia Found in Obese Young Men

Hyperandrogenism is a medical condition characterized by high levels of androgens in females, but men with obesity may be at increased risk for developing hypoandrogenemia or low free testosterone, especially if they have more severe obesity. More...
12 Sep 2019
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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