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Clinical Chemistry

Image: The cobas c502 automatic chemical analyzer (Photo courtesy of Roche Diagnostics).

Assay Improves Measurement of Blood Ammonia

Increased blood ammonia is an indicator and a prognostic factor for hepatic or kidney disease and inborn errors of amino acid metabolism. Ammonia can be also increased due to therapy with drugs such as valproic acid and chemotherapeutic agents. More...
31 Dec 2018
Image: Blood smears from normal and macrocytic anemia patients (Photo courtesy of Myrtle Porter).

Macrocytic Anemia Associated with HBV Liver Impairment Severity

Cirrhosis is an end-stage disease that invariably leads to death and it is the 14th most common cause of death in adults worldwide and results in 1.03 million deaths per year. Chronic infection with hepatitis B virus (HBV) is one of the major causes of cirrhosis and 30% of deaths are attributable to HBV. More...
19 Dec 2018
Image: The Lumipulse G 25-OH Vitamin D is an immunoreaction cartridge for in vitro diagnostic for the quantitative determination of 25-hydroxyvitamin D (25(OH)D) in human serum or plasma to be used in the assessment of Vitamin D sufficiency (Photo courtesy of Fujirebio).

Vitamin D Measured in Patients with Diabetic Foot

Peripheral artery disease (PAD) is the underlying predisposing factor in the etiology of the majority of diabetic feet. Vitamin D plays a role in calcium and bone metabolism and it is known to be an important immune modulator agent. More...
19 Dec 2018
Image: The Nexera X2 Ultra High Performance Liquid Chromatography (UHPLC) system (Photo courtesy of Shimadzu).

Neonatal Vitamin D Status Linked to Schizophrenia Risk

Schizophrenia is a poorly understood group of brain disorders characterized by impairments in cognition, perception and affect, with a lifetime prevalence of 0.7%. People with schizophrenia may seem like they have lost touch with reality. More...
18 Dec 2018
Image: A section from the hippocampus of an Alzheimer’s disease patient stained with a tau antibody (TNT1). Note the classical triad of tau pathologies in AD, 1) neurofibrillary tangles (arrowheads), 2) neuropil threads (arrows), and 3) a neuritic plaque (asterisk) (Photo courtesy of Michigan State University).

Tau Blood Test Developed for Alzheimer's Disease

Presently, the only way to definitively diagnose Alzheimer's disease in life is through brain scans and tests of cerebrospinal fluid that must be collected via lumbar puncture. Though cumbersome and expensive, such tests provide the most accurate diagnoses for patients. More...
17 Dec 2018
Image: The continuous glucose monitoring (CGM) system (Photo courtesy of Medtronic).

Diabetic Retinopathy Linked to Glycemic Variability in Type 2-Diabetes

Latent autoimmune diabetes in adults (LADA) refers to adult diabetes patients who are initially non‐insulin requiring, but have type 1 diabetes mellitus‐associated autoantibodies and who often progress to insulin dependency. More...
13 Dec 2018
Image: The BC-5390CRP blood cell analyzer (Photo courtesy of Mindray).

Potential Biomarkers Found for Acute Aortic Dissection

An aortic dissection is a serious condition in which the inner layer of the aorta, the large blood vessel branching off the heart, tears. Blood surges through the tear, causing the inner and middle layers of the aorta to separate (dissect). More...
10 Dec 2018
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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