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Clinical Chemistry

Image: An Agilent 1290 ultra-high performance liquid chromatograph (UHPLC) coupled to an Agilent G6490 Triple Quadrupole Mass Spectrometer (Photo courtesy of Agilent Technologies).

New Biomarker Panel Could Accelerate Autism Diagnoses

Autism Spectrum Disorder is characterized by core symptoms of altered social communication and repetitive behaviors or circumscribed interests and has a prevalence of 1:59 children in the USA. Affected individuals vary enormously in the severity of their autistic characteristics as well as in the occurrence of many co-morbid conditions. More...
17 Sep 2018
Image: The Q Exactive hybrid quadrupole-orbitrap mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

Residual Tissue Repositories Suitable for MS-Based Proteomics

Mass spectrometry-based proteomics has become a powerful tool for the identification and quantification of proteins from a wide variety of biological specimens. More...
12 Sep 2018
Image: Breast tissue from a relapsed patient with active phosphorylation markers (left; brown color), compared to breast tissue from a patient without relapse and who does not have these active markers (right) (Photo courtesy of Centro Nacional de Investigaciones Oncológicas).

Prognostic Biomarkers Identified for Aggressive Breast Cancer

The rarest, but also the most aggressive and hard to treat, form of breast cancer, is known as triple negative. For this type of cancer, oncologists have so far been unable to identify markers that can classify patients by prognosis or probability of responding to different treatments. More...
11 Sep 2018
Image: The MAGPIX clinical multiplexing analyzer system (Photo courtesy of Luminex).

Biomarker Low Predictive Power Validated for eGFR Decline

Glomerular filtration rate (GFR) is a measure of the function of the kidneys. This test measures the level of creatinine in the blood and uses the result in a formula to calculate a number that reflects how well the kidneys are functioning, called the estimated GFR or eGFR. More...
06 Sep 2018
Image: A diagram of proximity extension assay technology (Photo courtesy of Olink).

Inflammation Biomarkers Identified as Risk of Polyneuropathy

Polyneuropathy is one of the most common complications in people with diabetes. First symptoms are often pins-and-needles sensations in the feet. Although polyneuropathy is present in about 30% of people with diabetes, it often remains undiagnosed. More...
05 Sep 2018
Image: An illustration of obstructive sleep apnea compared to normal breathing during sleep (Photo courtesy of Mayo Clinic).

Sleep Disorder Linked with Abnormal Lipid Levels

Obstructive sleep apnea is a disorder in which breathing is repetitively interrupted during sleep due to collapse of the upper airway. An apnea is defined as complete cessation of breathing lasting 10 seconds or greater. More...
05 Sep 2018
Image: An S-100β (Human)-ELISA Kit (Photo courtesy of Yanaihara Institute).

Serum S-100β Elevated in Septic Shock Patients with Delirium

A high prevalence of delirium is observed in sepsis, yet specific markers for this brain dysfunction in sedated patients are still lacking. Cytoplasmic low molecular weight calcium-binding protein, S-100β, is a commonly used nonspecific marker for brain injury. More...
30 Aug 2018
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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