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Clinical Chemistry

Image: The Human KLK8/Kallikrein-8 ELISA Kit PicoKine is used to quantitate Human KLK8 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA) (Photo courtesy of Boster Biological Technology)

Blood Biomarker Kallikrein-8 Detects Amnestic Mild Cognitive Impairment

Alzheimer’s disease (AD) is a neurodegenerative disease and the most common cause of dementia. AD starts to damage the brain 20 years or more before any clinical symptoms appear. The currently available biomarker for AD (beta-amyloid (Aβ, A), tau (T), and neurodegeneration (N), (ATN)) are measured in cerebrospinal fluid (CSF). More...
10 Jan 2022
Image: The UBC Rapid is a qualitative test to detect cytokeratin fragments 8 and 18 in urine for bladder cancer detection (Photo courtesy of IDL Biotech)

Nomograms Including Rapid Antigen Test Detects Primary Bladder Cancer

Urinary bladder cancer (BC) is the tenth most prevalent cancer affecting mainly the elderly and men. The suspicion of BC often arises after the detection of microscopic or macroscopic (gross) hematuria during a patient’s examination. More...
04 Jan 2022
Image: Normal or Near Normal Aminotransferase Levels Found in Patients with Alcoholic Cirrhosis (Photo courtesy of Biology Dictionary)

Near Normal Aminotransferase Levels Reported in Alcoholic Cirrhosis Patients

Alcoholic cirrhosis affects around 1 in 400 adults in the USA. It is an advanced form of liver disease, which occurs when chronic ethanol use leads to inflammation and cirrhosis or scarring of the liver. Less than 50% of people diagnosed with advanced liver disease due to cirrhosis survive for one year, and so early diagnosis is crucial. More...
30 Dec 2021
Image: The High Sensitivity C-Reactive Protein ELISA kit (Photo courtesy of Genuine Biosystem)

Serum High Sensitivity C-Reactive Protein Associated With Pre-Diabetes

Individuals with pre-diabetes are at a higher risk for progression to diabetes and are also known to be associated with an increased risk of cardiovascular disease. Also, pre-diabetes is known to be associated with obesity and an abnormal lipid profile. More...
29 Dec 2021
Image: The Phadia 200 instrument is capable of diagnostic testing menu of more than 700 different ImmunoCAP and EliA tests to aid in the diagnosis of allergy and autoimmune diseases (Photo courtesy of Thermo Fisher Scientific)

Calprotectin Levels Vary When Measured in Different Matrices for COVID-19

Several risk scores, diagnostic imaging and biomarkers have been evaluated and compared to help predict severe complications and outcome in COVID-19 patients. Nevertheless, early prediction of COVID-19 severity remains difficult, emphasizing the need for additional biomarkers in daily practice. More...
28 Dec 2021
Image: Schematic graphics showing how variation in common laboratory test results caused by ambient temperature (Photo courtesy of Cell Press)

Seasonal Temperature Impacts Patients’ Laboratory Results

Every year, 13 billion laboratory tests are performed in the USA, nearly 800 million in the UK, and many more worldwide. Test results provide critical data on clinically important changes in patient physiology. More...
23 Dec 2021
Image: D-Serine is useful for the measurement of glomerular filtration rate (GFR). The clearance of D-serine has an advantage of lower bias against GFR compared to that with the creatinine clearance. Combinational clearance measurement of D-serine and creatinine can serve as a measure of GFR with precision and low bias (Photo courtesy of Tomonori Kimura, MD, PhD)

D-Serine Clearance Evaluates Precise Measurement of Kidney Function

Evaluation of kidney function is essential in daily clinical practice. The measured glomerular filtration rate (mGFR) using exogenous inulin has been considered as the gold standard of kidney function, though this procedure is labor intensive, time consuming, and expensive. More...
21 Dec 2021
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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