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Clinical Chemistry

Image: Multiomic prediction of time to labor from biomarkers in maternal blood (Photo courtesy of STELZER ET AL.)

Maternal Multiomic Changes Could Predict Onset of Labor

Currently, predictions of when labor will start are imprecise and based on gestational age and an average pregnancy length of 40 weeks, even though the onset of labor between week 37 and 42 of pregnancy is considered normal. Having a better idea of when labor may arrive could help with planning and managing medical concerns like fetal lung maturation. More...
18 May 2021
Image: Schematic diagram of a rich meconium metabolome in human infants is associated with early-life gut microbiota composition and reduced allergic sensitization (Photo courtesy of University of British Columbia)

Meconium Microbiome Can Help Predict Risk of Developing Allergies

Meconium, which is typically passed within the first day of life, is made up of a variety of materials ingested and excreted during development, ranging from skin cells, amniotic fluid and various molecules known as metabolites. More...
12 May 2021
Image: Immulite 2000 XPi immunoanalyzer system (Photo courtesy of Siemens Healthcare Diagnostics)

Maternal Free Thyroxine Associated with Gestational Diabetes

Hyperglycemia resulting from glucose intolerance during pregnancy, known as gestational diabetes mellitus (GDM), is a common complication during pregnancy and has a major impact on public health worldwide. More...
06 May 2021
Image: The FUS-2000 automated urine analyzer (Photo courtesy of DIRUI)

ANGPTL8 Levels Associated with Hyperlipidemia in Primary Nephrotic Syndrome

The typical clinical manifestations of Primary Nephrotic Syndrome (PNS) include massive proteinuria, hypoproteinemia, edema and/or hyperlipidemia. Of these, marked proteinuria is the core clinical manifestation, and its severity often parallels the degree of hyperlipidemia. More...
28 Apr 2021
Image: Altered Perivascular Fibroblast Activity Precedes Amyotrophic Lateral Sclerosis Onset (Photo courtesy of Karolinska Institutet)

Altered Perivascular Fibroblast Activity Precedes ALS Disease Onset

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor neurons that eventually causes muscular atrophy, paralysis and death. There is currently no cure. The cause of ALS is only understood in the 5% to 10% of patients who have an inherited form of the disease. More...
28 Apr 2021
Image: The Simoa HD-1 Analyzer (Photo courtesy of Quanterix)

Blood-Based Markers Tied to Brain Cell and Memory Loss

Previous studies have linked elevated levels of plasma total tau and neurofilament light chain (NfL) with worse cognition and neuroimaging measures of cortical thickness, cortical atrophy, white matter hyperintensity, or white matter integrity. More...
27 Apr 2021
Image: The cobas c 701 module is a high throughput clinical chemistry module that performs photometric assay tests for a wide range of analytes (Photo courtesy of Roche Diagnostics)

Serum α-L-Fucosidase Activity Measured for COVID-19 Infection

An unusual fucosylated LacdiNAc in the receptor-binding domains of the spike protein of COVID-19 has been observed. Reduced fucosylation was also found in a specific Fc domain of IgG antibodies in COVID-19 patients that enhanced the interactions with the activating FcγR, FcγRIIIa. More...
22 Apr 2021
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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