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Clinical Chemistry

Image: Liver function test abnormalities at hospital admission are associated with severe course of SARS-CoV-2 infection (Photo courtesy of Life Line Screening).

Abnormal Liver Function Test Associated with Severe SARS-CoV-2 Infection

COVID-19 predominantly affects the pulmonary tract causing mainly respiratory symptoms, however, involvement of other organ systems has been described, including myocarditis, acute kidney injury, neurological abnormalities and acute liver injury. More...
15 Feb 2021
Image: Inter-α-inhibitor heavy chain 4 (ITIH4) inhibits proteases in the innate immune system via novel inhibitory mechanism (Photo courtesy of Rasmus Kjeldsen Jensen, PhD).

New Control Mechanism Discovered in Innate Immune System

Proteases are enzymes that cleave other proteins. Most often, proteases occur in cascade networks, where a particular event triggers a chain reaction in which several proteases cleave and thereby activate each other. Most well-known is probably the coagulation cascade, which causes clotting of our blood when a vessel is punctured. More...
11 Feb 2021
Image: The Ortho VITROS 5600 integrates clinical chemistry and immunoassay testing (Photo courtesy of Ortho‐Clinical Diagnostic)

Reference Intervals for Liver Function Tests Established for Minors

The liver is a large and complex organ that plays a central role in carbohydrate, protein, and fat metabolism. Liver function tests can reflect the degree of damage to human liver parenchyma, fibrosis, synthesis status, and coagulation function. More...
04 Feb 2021
Image: The UriSed 3 PRO is a professional automated urine sediment analyzer with a revolutionary new optical system combining bright-field and phase contrast microscopy (Photo courtesy of 77 Elektronika)

Automated Urine Microscope Verified for Regional Laboratories

Automated Urine Microscopy examines a sample of urine under a microscope. It can check cells from the urinary tract, blood cells, crystals, bacteria, parasites, and cells from tumors. This test is often used to confirm the findings of other tests or add information to a diagnosis. More...
03 Feb 2021
Image: ACQUITY I-Class UPLC coupled with Xevo TQ-S mass spectrometer (Photo courtesy of Waters Corporation).

UPLC-MS/MS Method Simultaneously Determines Plasma Catecholamines and Their Metabolites

Phaeochromocytomas and paragangliomas (PPGLs) are rare tumors of adrenal chromaffin cells or extra-adrenal paraganglia. They are difficult to diagnose because of the non-specific clinical symptoms such as hypertension, palpitations, flushing and sweating. More...
27 Jan 2021
Image: Tryptophan metabolism is dysregulated in individuals with Fanconi anemia (Photo courtesy of Cincinnati Children’s Hospital Medical Center).

Tryptophan Metabolism Is Dysregulated in Individuals with Fanconi Anemia

Fanconi anemia (FA) is a complex genetic disorder frequently associated with progressive marrow failure and a strong predisposition to early malignancies, particularly squamous cell carcinomas and hepatocellular carcinomas. More...
20 Jan 2021
Image: Photomicrograph of a section of human skin showing a vacuolar interface dermatitis with dermal mucin. These findings are consistent with discoid skin lesions in lupus dermatitis (Photo courtesy of Nephron).

Serum Pentosidine Levels Measured in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE), is the most common type of lupus. SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. More...
14 Jan 2021
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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