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Molecular Diagnostics

Image: Translocation: a fragment of a chromosome is moved (trans-located) from one chromosome to another and joins a non-homologous chromosome. The balance of genes is still normal (nothing has been gained or lost), but can alter phenotype as it places genes in a new environment (Photo courtesy of Indiana University).

Chromosomal Abnormalities Associated with Recurrent Miscarriage

Recurrent miscarriage, or the loss of two or more pregnancies, affects between 1% and 2% of couples. Chromosomal abnormalities are the major genetic cause of miscarriage and are detected by routine analysis in about 1 in 50 couples. More...
11 Nov 2019
Image: A liquid biopsy blood test that measures the amount of cell-free DNA (cfDNA) in the bloodstream correlates with how patients will progress after they are diagnosed with glioblastoma (Photo courtesy of University of Pennsylvania School of Medicine).

Use of Cell-free DNA Liquid Biopsy to Predict Glioblastoma Progression

Cancer researchers have demonstrated the potential clinical utility of liquid biopsy to measure plasma cell-free DNA (cfDNA) in patients with newly diagnosed glioblastoma in order to predict the progression of the disease. More...
11 Nov 2019
Image: A scanning electron micrograph (SEM) of prostate cancer cells (Photo courtesy of Sloan Kettering Institute).

Prostate Cancer Methylation Levels Linked to Epigenetic Profiles

Prostate cancer is cancer that occurs in the prostate, a small walnut-shaped gland in men that produces the seminal fluid that nourishes and transports sperm. Prostate cancer is one of the most common types of cancer in men. More...
07 Nov 2019
Image: A micrograph of ALL cancer cells (Photo courtesy of Baylor College of Medicine).

Metabolomic Profiling Identifies ALL Patients at Risk for MRD and Cancer Relapse

Metabolomic profiling of bone marrow from patients suffering from acute lymphoblastomic leukemia was used to identify those who were at high risk of developing minimal residual disease and cancer relapse. More...
07 Nov 2019
Image: The High Pure Viral RNA Kit is for general laboratory use and purifies viral RNA from a variety of samples such as serum and plasma (Photo courtesy of Roche Diagnostics).

Enterovirus D type 111 Genetically and Phenotypically Characterized

Members of the species Enterovirus D (EV-D) remain poorly studied. The two first EV-D types (EV-D68 and EV-D70) have regularly caused outbreaks in humans since their discovery five decades ago but have been neglected until the recent occurrence of severe respiratory diseases due to EV-D68. More...
06 Nov 2019
Image: The pancreas and surrounding organs (Photo courtesy of Wikimedia Commons).

Whole-exome Sequencing Identifies Mysterious Pancreatitis Mutation

By applying advanced whole-exome sequencing analysis techniques, researchers have identified a mutation linked to a rare form of inhertied pancreatitis. More...
06 Nov 2019
Image: The HiSeq X Series incorporates patterned flow cell technology to generate an exceptional level of throughput for whole-genome sequencing (Photo courtesy of Illumina).

Metastatic Tumor Profiles Lead to Potential Treatment Targets

Metastatic cancer is a major cause of death and is associated with poor treatment efficacy. A better understanding of the characteristics of late-stage cancer is required to help adapt personalized treatments, reduce overtreatment and improve outcomes. More...
05 Nov 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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