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Hematology

Image: LeukoPrint is a first-in-class leukemia sWGS CNA test (Photo courtesy of SeekIn Inc.)

First-of-Its-Kind Molecular Karyotyping Test Assists Hematologists in Diagnosing Leukemia

A new test kit can evaluate copy number aberrations (CNAs) in bone marrow cells and/or circulating cell-free DNA (cfDNA) via shallow whole-genome sequencing (sWGS), in combination with conventional cytogenetics technologies, to make leukemia diagnosis, molecular subtyping, prognostic stratification and treatment response monitoring more precise and comprehensive. More...
11 Apr 2022
Image: Antioxidant, inflammation levels may reveal new diagnostic tool for breast cancer (Photo courtesy of Pexels)

Blood Tests for Detecting Antioxidant and Inflammation Levels Could Diagnose Breast Cancer

Breast cancer is the most prevalent cancer in the world. Identifying new diagnostic techniques is of major importance to efforts that aim to minimize the disease’s devastating effects. Now, a new study that analyzes levels of antioxidants and stress markers in the blood could lead to a new diagnostic tool for breast cancer. More...
07 Apr 2022
Image: LyoPlas is freeze-dried plasma and combined packed red blood cells were compared to 0.9% saline for resuscitation of trauma-related hemorrhagic shock patients (Photo courtesy of DRK-Blutspendedienst West gGmbH)

Blood Products Use in Trauma-Related Hemorrhagic Shock Patients Questioned

Treatment of hemorrhagic shock is now increasingly focused on the early use of hemorrhage control, tranexamic acid, and blood-based resuscitation with packed red cells and plasma. The improved survival from these and other strategies within streamlined trauma systems have been reported in the military and civilian settings, and have stimulated an interest in prehospital transfusion. More...
05 Apr 2022
Image: The BD FACSAria III cell sorter is equipped with 4 lasers and the instrument enables multicolor analysis of up to 15 parameters (Photo courtesy of BD Biosciences)

Deep Sequencing of CD34+ Cells Detects Measurable Residual Disease in AML

Monitoring of measurable residual disease (MRD) in patients with acute myeloid leukemia is predictive for disease recurrence and may identify patients who benefit from treatment intensification. Current MRD techniques rely on multicolor flow cytometry or molecular methods, but are limited in applicability or sensitivity. More...
31 Mar 2022
Image: Photomicrograph of classic Hodgkin lymphoma (cHL) fine needle aspiration from a lymph node. The micrograph shows a mixture of cells common in cHL: eosinophils, Reed-Sternberg cells, plasma cells, and histocytes (Photo courtesy of Nephron)

Flow Cytometric Immunophenotyping Assessed for Classic Hodgkin Lymphoma

The diagnosis of classic Hodgkin lymphoma (CHL) requires morphologic and immunophenotypic identification of neoplastic Hodgkin and Reed-Sternberg cells (collectively referred to as HRS cells) intermixed with a background of reactive lymphocytes, histiocytes, plasma cells, and eosinophils. More...
24 Mar 2022
Image: AlzoSure Predict is a prognostic blood test for Alzheimer’s disease (Photo courtesy of Diadem srl)

First Non-Invasive Blood-Based Test Has Potential to Accurately Diagnose Alzheimer's Disease

Diadem srl (Milan, Italy) has presented data showing that its new AlzoSure Confirm blood test can accurately identify patients with Alzheimer's disease. AlzoSure Confirm has been developed on the same technology platform that underlies AlzoSure Predict, Diadem's prognostic blood test that can accurately predict whether or not an individual with early cognitive changes will progress to Alzheimer's disease up to six years before the condition is fully manifested. More...
24 Mar 2022
Image: The Orbitrap Fusion Mass Spectrometer was used to identify the biomarker panel for risk of early respiratory failure following hematopoietic cell transplantation (Photo courtesy of Thermo Fisher Scientific)

Biomarker Panel for Risk of Early Respiratory Failure Following Hematopoietic Cell Transplantation

Allogeneic hematopoietic cell transplantation (HCT) is a life-saving therapy used for malignant and nonmalignant diseases. However, post-HCT pulmonary complications continue to be a significant problem. When severe, pulmonary complications can result in respiratory failure (RF), affecting 10% to 23% of patients. More...
23 Mar 2022
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.

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