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Hematology

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Qiagen and Denovo Biopharma to Develop Blood-Based CDx Test for Treatment of Diffuse Large B-Cell Lymphoma

QIAGEN N.V. (Venlo, Netherlands) and Denovo Biopharma LLC (San Diego, CA, USA) have entered into a collaboration to develop a blood-based companion diagnostic (CDx) test to identify patients expressing Denovo Genomic Marker 1 (DGM1TM) who are likely to respond to Denovo’s investigational cancer drug DB102TM for treatment of diffuse large B-cell lymphoma (DLBCL), one of the most common lymphoid cancers. More...
21 Dec 2021
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New Diagnostic Blood Test Could Reveal Early Stage Lung Cancer in Asymptomatic Patients

A diagnostic blood test may provide early detection of lung cancer in asymptomatic patients, according to a new study. More...
16 Dec 2021
Image: Histopathology of Allergic bronchopulmonary aspergillosis. Grocott\'s Methenamine Silver Stain  shows branching and helps to confirm that the black structures are indeed fungal hyphae (Photo courtesy of Doctorlib)

Pulmonary Eosinophilia Indicates Onset of Allergic Bronchopulmonary Aspergillosis

Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder caused by type 2 immune responses to Aspergillus. This pathology usually develops after the onset of bronchial asthma (BA) or cystic fibrosis. Rates differ among countries, but appear to be increasing around the world with the increase of BA. More...
13 Dec 2021
Image: The BD LSRFortessa X-20 Cell Analyzer can be configured with up to five lasers to detect up to 20 parameters simultaneously to support ever increasing demands in multicolor flow cytometry (Photo courtesy of BD Bioscience)

Immunoprofiling HTLV-1 Blood Samples Show Altered Innate Cell Responsiveness

The Human T-cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a progressive neurodegenerative disease characterized by the demyelination of the middle-to-lower thoracic cord. More...
09 Dec 2021
Image: Blood smear from a patient with low grade follicular lymphoma in leukemic phase: note cleaved nuclei (coffee bean cells) and scant cytoplasm (Photo courtesy of Kyle Bradley, MD)

Classification of Mature B-Cell Neoplasms Employing Standardized Flow Cytometry

The classification of lymphoid neoplasms integrates clinical, pathological, immunophenotypic, genetic, and molecular data in order to distinguish between mature B-cell lymphoma entities. The precise classification of these entities (also known as B-cell chronic lymphoproliferative diseases, B-CLPD) has relevant therapeutic implications. More...
08 Dec 2021
Image: The UniCel DxH 800 Coulter Cellular Analysis System (Photo courtesy of Beckman Coulter)

Monocyte Distribution Width Predicts Sepsis in Critically Ill Patients

Sepsis has been reported as a major cause of increased morbidity, length of stay and mortality among patients hospitalized in Intensive Care Units (ICUs) for any cause. The survival of patients developing sepsis in the ICU is strictly related to an early diagnosis, as well as a prompt start of appropriate medical interventions. More...
06 Dec 2021
Image: The CP3000Automated Coagulation System measures various coagulation factors (Photo courtesy of Sekisui Medical Company)

Multiple Coagulation Parameters Predict Postoperative Bleeding Volume in Cardiovascular Surgery

Coagulopathy and massive bleeding are severe complications of cardiovascular surgery, particularly occurring after procedures requiring prolonged cardiopulmonary bypass (CPB). During surgery massive transfusion of blood products may become necessary. More...
02 Dec 2021
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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