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Immunology

Image: Histopathology of Guillain-Barré syndrome: Inflammation in peripheral nerve (Photo courtesy of Dimitri P. Agamanolis, MD).

Blood Biomarker Predicts Guillain-Barré Prognosis

Guillain-Barré syndrome (GBS) is a rare, autoimmune disorder in which a person’s own immune system damages the nerves, causing muscle weakness and sometimes paralysis. GBS can cause symptoms that last for a few weeks to several years. Most people recover fully, but some have permanent nerve damage. More...
25 Nov 2020
Image: An increase in Plasma P-tau217 may be considered as an early Alzheimer disease biomarker (Photo courtesy of Harvard Medical School).

Biomarker Detects Early Alzheimer’s Disease

In Alzheimer disease (AD), abnormal metabolism of amyloid-β (Aβ) and tau leads to accumulation of extracellular plaques formed by misfolded Aβ and intraneuronal neurofibrillary tangles containing phosphorylated tau (P-tau) protein. More...
24 Nov 2020
Image: The 5200 Fragment Analyzer system performs DNA QC and RNA QC for a broad range of samples including, gDNA, small RNA, cfDNA, large DNA fragments, and total RNA (Photo courtesy of Agilent Technologies).

CD200 Expression Marks Leukemia Stem Cells in Human AML

Acute myeloid leukemia (AML) is organized as a hierarchy sustained by a minor population of leukemia stem cells (LSCs) with self-renewal capacity that drive disease. The LSC populations of AML exhibit phenotypic, genetic, and functional heterogeneity that contribute to therapy failure and relapse. More...
17 Nov 2020
Image: The STANDARD F Dengue IgM/IgG FIA qualitatively analyzes Dengue virus specific IgM and IgG antibodies in serum, plasma and whole blood using fluorescent immunoassay (Photo courtesy of SD Biosensor).

Rapid Tests Evaluated in the Management of Dengue Fever

Dengue is a mosquito-borne infection caused by four distinct viruses (DENV 1-4) which belong to the flavivirus genus and may lead to diverse outcomes. The disease can be asymptomatic in about 75% of cases, causing Dengue fever (DF), or result in severe dengue. Dengue is common in more than 120 countries. More...
12 Nov 2020
Image: Autoantibody order, timing helps predict genetically susceptible children most likely to get type 1 diabetes (Photo courtesy of the Morsani College of Medicine).

Autoantibody Timing Predicts Genetically At-Risk Children for Diabetes

While antibodies are molecules produced by the body's immune system to detect and destroy specific viruses, bacteria and other harmful substances, autoantibodies are antibodies that target a person's own healthy tissue. In the case of type 1 diabetes (T1D), a misdirected autoimmune response attacks the pancreas and gradually destroys the organ's insulin-producing beta cells. More...
11 Nov 2020
Image: The Buhlmann fCal Turbo turbidimetric immunoassay measures fecal calprotectin in stool specimens (Photo courtesy of Buhlmann Diagnostics).

Novel Fecal Calprotectin Test Validated in Pediatric Population

Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are increasingly prevalent disorders with overlapping clinical presentations. Distinguishing between these two classes of disease is important, as while IBS is an idiopathic functional disorder, IBD is characterized by chronic inflammation and tissue destruction. More...
10 Nov 2020
Image: The iFlash 1800 chemiluminescence immunoassay analyzer (Photo courtesy of Shenzhen YHLO Biotech).

Serum-IgG Responses in Patients with Mild and Severe COVID-19

The coronavirus disease 2019 (COVID-19) pandemic continues, causing considerable morbidity and mortality worldwide. The severity of COVID-19 ranges from asymptomatic to fatal pneumonitis, with mildly symptomatic patients accounting for approximately 80% of all cases according to current understanding. More...
04 Nov 2020
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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