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Immunology

The V-Plex Pro-inflammatory Panel 1 Human Kit (Photo courtesy of Meso Scale Diagnostics).

Lab Profiles Differentiate MIS-C From Severe Pediatric COVID-19

Initial reports from the Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) pandemic described children as being less susceptible to Coronavirus Disease 2019 (COVID-19) than adults. Subsequently, a severe and novel pediatric disorder termed Multisystem Inflammatory Syndrome in Children (MIS-C) emerged. More...
19 Aug 2020
The QuantiFERON‐TB Gold Plus IFN‐γ release assay used to help diagnose hemophagocytic lymphohistiocytosis (Photo courtesy of Qiagen).

IFN‐γ Release Assay Helps Diagnose Hemophagocytic Lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH), either primary (pHLH, or Familiar, FHL) or secondary is a life‐threatening hyper‐inflammatory syndrome, characterized by massive and uncontrolled activation of macrophages and T cells, causing fever, cytopenia and liver dysfunction with coagulopathy. More...
14 Aug 2020
In situ expression of chemokines eotaxin, IL-8, and MIP-1α in glomerular and tubulointerstitial compartments in patients with diabetic nephropathy (DN) and control group (Photo courtesy of Federal University of Triângulo Mineiro).

Renal Expression of Immunomodulators in Diabetic Nephropathy

Diabetic nephropathy (DN) is a chronic microvascular complication that affects about 20% to 30% of patients with type 2 diabetes mellitus (T2DM). It is considered the leading cause of end-stage renal failure requiring renal replacement therapy. More...
12 Aug 2020
Image: The Melioidosis DS assay principle: A dipstick is placed into a well containing patient serum diluted in dipstick master mix (running buffer, detection antibody and control reagent) (Photo courtesy of Medical University of Graz).

Serological Dipstick Assay Developed for Melioidosis

The Gram-negative environmental pathogen Burkholderia pseudomallei, causes the severe disease melioidosis. It is highly endemic in southeast Asia and northern Australia, but recent studies suggest that it is also present in many other parts of the world where it is severely underreported. More...
05 Aug 2020
Image: Graphic diagram of how the cytokine IL-17A limits Th17 pathogenicity via a negative feedback loop driven by autocrine induction of IL-24 (Photo courtesy of the US National Eye Institute).

Dual Role Discovered for Interleukin-17A in Autoimmune Uveitis

Autoimmune uveitis (AU) is an inflammatory process of the uveal components of the eye, due to an autoimmune reaction to self-antigens or caused by an innate inflammatory reaction secondary to an external stimulus. It can present as an isolated entity or associated with a systemic autoimmune or autoinflammatory disease. More...
04 Aug 2020
Image: An enzyme-linked immunosorbent assay (ELISA) was used to measure melatonin which was significantly higher in Parkinson’s disease patients (Photo courtesy of Gold Biotechnology).

Melatonin Levels in Parkinson’s Patients Linked to Non-Motor Symptoms

Parkinson’s disease (PD) is a complex neurodegenerative disease characterized by the loss of dopaminergic neurons in the pars compacta (SNpc), resulting in the classic motor manifestations in PD patients. The clinical diagnosis of PD mainly relies on the presence of motor symptoms as the disease progresses. More...
21 Jul 2020
Image: The Immunogenomic Landscape of Hematological Malignancies (Photo courtesy of Helsinki University Hospital).

Immunogenomic Landscape of Hematological Malignancies Mapped

The reaction of the body's immune system against cancer can be thought of as a cycle. Cancer cells contain proteins that differ from proteins in other tissue. Their components, known as antigens, have to be presented to the T cells of the immune system by the cancer cells. More...
20 Jul 2020
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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