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Immunology

Image: The LDBIO test relies on an immunochromatographic lateral-flow assay. This system is designed to detect the presence (or absence) of IgG and IgM antibodies, indicative of Toxoplasma infection (Photo courtesy of the University of Chicago).

POC Blood Test Can Help Prevent Toxoplasmosis

Toxoplasma gondii gains access to human hosts when they eat undercooked contaminated meat or are exposed to material contaminated by feces from an acutely infected cat, which usually goes unrecognized. More...
28 Aug 2018
Image: Specificity assay of Yersinia F1-strips. Six Yersinia strains (105 CFU/mL each) were applied on Yersinia-F1-strips. Strip 1: Y. pestis yreka; 2: Y. mollaretii; 3: Y. frederiksenii; 4: Y. pseudotuberculosis; 5: Y. enterocolitica; 6: Y. intermedia; 7: PCB buffer (Photo courtesy of National Defense Medical Center).

Lateral-Flow Assay Rapidly Detects Plague Bacteria

Plague caused by Yersinia pestis is a known flea-borne disease that can trigger large epizootics among the rodent population. Humans that live in environments close to these rodents can contract the bubonic plague either through direct contact with infected animals or through transmission by infective flea bites. More...
28 Aug 2018
Image: The RF-20A fluorescence detector for use with high performance liquid chromatography (Photo courtesy of Shimadzu).

Biomarkers Explored in Patients with Acute Coronary Syndromes

Well-developed coronary collateral arteries are associated with improved survival in patients with coronary artery disease. A key process in forming new blood vessels is attraction to occluded arteries of monocytes with their subsequent activation as macrophages. More...
28 Aug 2018
Image: A C-telopeptide of type 1 collagen (CTX) assay kit (Photo courtesy of Wako Chemicals).

Biochemical Markers Predict Risk of Incident Diabetes

Low osteocalcin and C-telopeptide of type 1 collagen levels in postmenopausal women are associated with an increased risk for insulin resistance and incident diabetes. More...
22 Aug 2018
Image: Vascular cell adhesion protein 1 (VCAM‐1) enzyme-linked immunosorbent assay kit (Photo courtesy of PerkinElmer).

Biomarkers Linked to Fatigue in Parkinson’s Disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking. More...
21 Aug 2018
Image: The ARCHITECT i2000SR immunoassay analyzer (Photo courtesy Abbott Diagnostics).

Fifth-Generation Cardiac Troponin Assays Compared

Cardiac troponin I (cTnI) and cardiac troponin T (cTnT) are highly specific biomarkers of myocardial injury. The 99th percentile upper reference limit (URL) of a normal reference population is the recommended threshold which defines an increased cTnI or cTnT plasma concentration indicative for myocardial injury. More...
20 Aug 2018
Image: Positive and negative results detected by the lateral flow immunochromatographic assay AcQuickDx test for Angiostrongylus cantonensis (Photo courtesy of Faculty of Medicine Siriraj Hospital).

Immunochromatographic Test Rapidly Diagnoses Parasitic Infection

The rat lungworm Angiostrongylus cantonensis is a food-borne zoonotic parasite that causes eosinophilic meningitis in humans. Suspected cases of A. cantonensis infection can only be confirmed by finding the nematodes in cerebral spinal fluid (CSF) of the patients. More...
15 Aug 2018
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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