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Immunology

Image: Immunohistochemical (IHC) analysis of the normal tissue from a healthy subject showed several Matrix Metalloproteinase-13 (MMP-13) positive cells (light brown staining indicated by the red arrow in panel a. Panel b is an IHC microphotograph for the cSCC tissue, and brown staining can be seen in most of tumor cells (Photo courtesy of Weifang People’s Hospital)

Diagnostic Biomarker MMP-13 Explored for Cutaneous Squamous Cell Carcinoma

Cutaneous basal cell carcinoma (cBCC) and cutaneous squamous cell carcinoma (cSCC) account for approximately 80% and 20% of non-melanoma skin cancer (NMSC), respectively Although the majority of cSCCs are successfully eradicated by surgical excision, a subset of cSCC possesses features associated with a higher likelihood of recurrence, metastasis, and death. More...
27 Jul 2021
Image: The Cytomics FC500 Flow Cytometer System (Photo courtesy of Beckman Coulter Life Sciences)

T-Cell CD27 Expression Assessed for Smear-Negative Tuberculosis

Mycobacterium tuberculosis (MTB) and its related disease tuberculosis (TB) are infectious diseases with a worldwide focus. Although both vaccines and anti-TB drugs are available, there is a global focus on illness diagnosis in smear-negative and latent tuberculosis infectious populations (SN-TB and LTBI). More...
27 Jul 2021
Image: The HE4 EIA is an enzyme immunometric assay for the quantitative determination of human epididymis protein 4 (HE4) in human serum. HE4 is consistently expressed in patients with ovarian cancer, and it has demonstrated increased sensitivity and specificity over that of CA125 alone (Photo courtesy of Fujirebio)

Immunoassays Compared for Serum HE4 Estimation for Ovarian Cancer

Ovarian cancer is the sixth most common cancer in women and the leading cause of death from gynecological malignancy in the UK. Cancer antigen 125 (CA125) is the most widely used diagnostic biomarker for ovarian cancer; however it lacks the diagnostic accuracy to reliably detect ovarian cancer at an early stage. More...
26 Jul 2021
Image: The ProSpecT Rotavirus Microplate ELISA Assay (Photo courtesy of Thermo Fisher Scientific)

Rotavirus Co-Infection with Diarrheagenic Pathogens Detected by Different Methods

Diarrhea is the second most common cause of childhood mortality worldwide, with Group A Rotavirus (RVA) recognized as a leading diarrheagenic agent, causing 38% of acute diarrhea among children aged five and below worldwide. More...
14 Jul 2021
Image: The MAGLUMI 800 Automatic immunoassay analyzer (Photo courtesy of Snibe)

Automated Immunoassays Evaluated for Immune Response to SARS-CoV-2

As part of the fight against the SARS-Cov-2 epidemic, laboratories have a critical role in assessing the reliability of new serological assays before taking part of diagnostic protocols or made available broader to the community and to evaluate commutability between assays. More...
12 Jul 2021
Image: Elevated levels of two inflammatory proteins, IL-12p70 and IFN-γ, were associated with slower cognitive decline in older adults (Photo courtesy of Scientific Animations Inc)

Two Inflammatory Proteins Linked with Slower Cognitive Decline

Previous meta-analyses of case-control and prospective cohort studies showed that cytokines and inflammatory markers, such as interleukin-6 (IL-6), C-reactive protein (CRP), and others are elevated in Alzheimer's dementia cases and predicted incident of all-cause dementia. More...
08 Jul 2021
Image: Enzyme-linked immunosorbent assay (ELISA) kit for Fatty acid-binding proteins 4 (FABP4) (Photo courtesy of Biovendor R&D)

FABP4 Concentrations Quantified in Proliferative Diabetic Retinopathy

Proliferative diabetic retinopathy (PDR), a progressive and serious stage of diabetic retinopathy (DR) due to retinal ischemia, is characterized by neovascularization (NV), vitreous hemorrhaging (VH) and tractional retinal detachment (TRD), all of which are major causes of blindness in patients with diabetes mellitus (DM). More...
07 Jul 2021
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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