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Pathology

Image: The myTAIHEART test is a powerful non-invasive test that uses a small sample of blood to determine if a patient is at a low or increased risk of rejecting their heart transplant. myTAIHEART works by measuring the fraction of cell-free DNA (cfDNA) present in the bloodstream that is attributable to the transplanted heart. An elevated donor fraction (DF%) is associated with an increased risk of acute cellular rejection (Photo courtesy of TAI Diagnostics).

Heart Transplant Monitoring Test Validated

 A heart transplant, or a cardiac transplant, is a surgical transplant procedure performed on patients with end-stage heart failure or severe coronary artery disease. Noninvasive risk assessment for rejection in heart transplant recipients, both adult and pediatric, is an imperative and urgent clinical need. More...
06 Feb 2020
Image: Photomicrograph of the bacterium, Fusobacterium nucleatum: gram-negative stained from culture (Photo courtesy of J. Michael Miller, PhD, (D)ABMM)

Microbiota’s Role Explored in Colorectal Cancer Among the Young

 Colorectal cancer incidence has been declining for several decades in people over 55, in part because of the increased use of screening for the disease, particularly with colonoscopy which can find and remove polyps before they become cancerous. More...
06 Feb 2020
Image: A melanoma on a patient`s skin: a new test predicts which melanoma patients are at risk of cancer recurrence and metastases (Photo courtesy of US National Cancer Institute).

Technique Predicts Cancer Recurrence Risk for Melanoma Patients

 Many primary melanomas can be cured by having this lesion removed, but melanoma can also recur and spread; an analysis of the removed lesion can offer some information on the likelihood that the cancer will recur. More...
05 Feb 2020
Image: The Hyperion Imaging System brings proven CyTOF technology together with imaging capability to empower simultaneous interrogation of four to 37 protein markers using Imaging Mass Cytometry (Photo courtesy of Fluidigm).

Imaging Mass Cytometry Uncovers Novel Breast Cancer Subgroups

 Changing the course of how diseases are treated and ultimately cured requires a comprehensive understanding of complex cellular phenotypes and their interrelationships in the spatial context of the tissue microenvironment. More...
03 Feb 2020
Image: In the brain of mice with Alzheimer\'s, areas near amyloid plaques (A) appear with fewer neural networks (B), dying neurons (C) and higher OCIAD1 (D). In cultured neuronal cells, the OCIAD1 proteins (E) appear in the mitochondria (F) (Photo courtesy of Houston Methodist Research Institute).

Ovarian Cancer Protein Contributes to Alzheimer`s Disease Neurodegeneration

 Alzheimer's disease is a complex neurological disorder with pathological hallmarks of hyperamyloidosis (senile plaques), neurofibrillary tangles containing hyperphosphorylated tau, and extensive neurodegeneration in the brain. More...
30 Jan 2020
Image: The DS-11 Series of Spectrophotometers are used to perform fast quantification of nucleic acids and proteins (Photo courtesy of DeNovix).

Homologous Recombination Defects Prevalent in African-American Cancer Patients

 In the USA, African-Americans have the highest cancer incidence and lowest survival across multiple cancer types. The reasons for these persistent trends are not clear. More...
28 Jan 2020
Image: Genome-wide association and Mendelian randomization analysis provide insights into the pathogenesis of heart failure (Photo courtesy of WebMD).

Genome-Wide Association Leads to Heart Failure Risk Loci

 Heart failure (HF) affects more than 30 million individuals worldwide and its prevalence is rising. HF-associated morbidity and mortality remain high despite therapeutic advances, with 5-year survival averaging around 50%. More...
23 Jan 2020
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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