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Pathology

Image: The Chromium Controller is a component of the Chromium platform designed to enable high-throughput analysis of individual biological components, such as up to millions of single cells (Photo courtesy of 10x Genomics).

Single-Cell Transcriptome Links Gut Development, Pediatric Crohn's Disease

Development of the human intestine is a highly complex process that requires synergy between a wide range of cell types. Importantly, environmentally triggered alterations in early development have been implicated in a range of immune-mediated pathologies, including inflammatory bowel diseases (IBD). More...
29 Dec 2020
Image: Illustration of Normal Heart versus Heart with Dilated Cardiomyopathy (Photo courtesy of Medical gallery of Blausen Medical).

Rare Genetic Variants Can Contribute to Ischemic Heart Failure

Heart failure affects about 40 million people globally, and most cases are due to ischemic heart disease, hypertension, or cardiomyopathies. Cardiomyopathies have been traced to rare variants in genes that encode sarcomere or cytoskeletal proteins, channels, or desmosomes, while genome-wide association studies have underscored common variants linked to heart failure. More...
29 Dec 2020
Image: Histopathology of dissected appendiceal tissue showing moderately differentiated neoplastic glands lined by cells with nuclear pleomorphism and hyperchromasia (Photo courtesy of Pacific Northwest University of Health Sciences).

Distinct Mutation Patterns Identified in Appendiceal Cancer

The incidence of appendiceal cancer (AC) is rising, particularly among individuals younger than 50 years (early-onset AC), with unexplained etiologies. The unique spectrum of somatic cancer gene variations among patients with early-onset AC is largely undetermined. More...
24 Dec 2020
Image: The CELLSEARCH Circulating Tumor Cell (CTC) Test is used for determining the prognosis of patients with metastatic breast, prostate and colorectal cancer (Photo courtesy of Menarini Silicon Biosystems).

Circulating Tumor Cell Dynamics Predicts Cancer Prognosis

Metastatic breast cancer, also called stage IV breast cancer, means the cancer has traveled through the bloodstream to create tumors in the liver, lungs, brain, bones and/or other parts of the body. Approximately 20% to 30% of women with early stage breast cancer go on to develop metastatic disease. More...
23 Dec 2020
Image: The UF-500i fully automated urine particle analyzer (Photo courtesy of Sysmex Corporation).

Flow Cytometry Employed in Diagnosing Male Urethritis

According to the established guidelines, diagnosis of non-gonococcal urethritis should be confirmed by demonstrating polymorphonuclear leukocytes from the anterior urethra using a Gram-stained (GSS) or methylene blue-stained urethral smear. More...
17 Dec 2020
Image: nCounter NanoString: Gene expression profiling platform (Photo courtesy of Institute Pasteur).

Gene Expression Signature Traces Nonalcoholic Fatty Liver Disease Progression

Nonalcoholic fatty liver disease (NAFLD) is a common condition marked by the accumulation of triglycerides and other lipids in the liver and is associated with metabolic syndrome, type 2 diabetes, hypertension, and dyslipidemia. More...
16 Dec 2020
Image: Triple fecal immunochemical testing (FIT) surpasses single sigmoidoscopy in colorectal cancer (CRC) screening (Photo courtesy of Pinnacle Biolabs).

Triple FIT Surpasses Single Sigmoidoscopy in CRC Screening

Colorectal cancer (CRC) almost always develops from precancerous polyps (abnormal growths) in the colon or rectum. Screening tests can find precancerous polyps, so that they can be removed before they turn into cancer. Screening tests can also find colorectal cancer early, when treatment works best. More...
10 Dec 2020
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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