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Pathology

Image: A graphic representation of Strain- and Species-Level Variation in the Microbiome of Diabetic Wounds Is Associated with Clinical Outcomes and Therapeutic Efficacy (Photo courtesy of the University of Pennsylvania).

Certain Bacteria Strains Associated with Diabetic Wounds

About 10% of Americans have been diagnosed with diabetes, and one quarter of these patients will develop a wound that does not heal. In the worst case outcome, which occurs in up to 25% percent of these wound-developing patients, the wounds will require an amputation. More...
01 May 2019
Image: A histopathology of oral cancer: tumor islands can be seen infiltrating the connective tissues deep to the overlying oral epithelium. This carcinoma is moderately differentiated with a non-cohesive invasive pattern (Photo courtesy of University of Sheffield).

Biomarkers of Oral Cancer Discovered

Epigenetics, the non-genetic influences on gene expression, is a powerful mechanism capable of altering gene expression in cancer cells without changes to the DNA sequence, and can cause tumor progression. More...
30 Apr 2019
Image: A sample collection kit for the expanded Multi-Cancer 83-gene comprehensive panel that increases diagnostic yield (Photo courtesy of Invitae).

Multi-Gene Panel Testing Catches Cancer Risk Variants

Over 608,000 patients with ovarian, breast, pancreatic, prostate and colorectal cancer are diagnosed each year. Current guidelines recommend testing all patients with ovarian and pancreatic cancer, as well as patients with prostate, breast and colorectal cancer (CRC) who meet certain criteria. More...
25 Apr 2019
Image: A histopathology of Hirschsprung’s disease, which is characterized by the absence of parasympathetic ganglion cells in both submucosal as well as myenteric plexuses in the distal gastrointestinal tract (Photo courtesy of Dr. Dharam Ramnani).

Suite of Risk Variants Revealed in Hirschsprung's Disease

Hirschsprung’s disease, or congenital aganglionosis, is a developmental disorder of the enteric nervous system and is the most common cause of intestinal obstruction in neonates and infants, often appearing in combination with other symptoms in a manner that may reflect specific syndromes. More...
23 Apr 2019
Image: A gram-negative stained culture of Fusobacterium nucleatum (Photo courtesy of J. Michael Miller, Ph.D., (D)ABMM).

CRC Gut Microbial Signatures Lead to Diagnostic Tests

Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine). A cancer is the abnormal growth of cells that have the ability to invade or spread to other parts of the body. More...
18 Apr 2019
Image: The Envisia Genomic Classifier Kit improves diagnosis for patients undergoing evaluation for interstitial lung diseases (ILDs), including idiopathic pulmonary fibrosis (IPF) (Photo courtesy of Veracyte).

Genomic Classifier Test for Lung Disease Validated

In the appropriate clinical setting, the diagnosis of idiopathic pulmonary fibrosis (IPF) requires a pattern of usual interstitial pneumonia to be present on high-resolution chest computerized tomography (HRCT) scan or surgical lung biopsy. More...
18 Apr 2019
Image: Droplet digital PCR measures tumor load by non-invasive means. The technique takes advantage of the cell-free DNA circulating in blood, which is found in higher concentration in cancer patients (Photo courtesy of Christof Winter, MD, PhD).

Liquid Biopsy Potential Tested with ddPCR Technology

Droplet digital polymerase chain reaction (ddPCR) technology has been used to investigate the benefits of tracking drug-resistance mutations in the circulating DNA (ctDNA) of patients with hormone receptor-positive (HR+) metastatic breast cancer. More...
10 Apr 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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