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Pathology

Image: A senior medical laboratory scientist conducting the IsolateFibromyalgia blood test (Photo courtesy of IquityLabs).

Novel RNA Blood Test Launched for Fibromyalgia

It is estimated that about five million Americans suffer from fibromyalgia, a poorly understood disorder characterized by deep tissue pain, fatigue, headaches, mood swings and insomnia. It often takes years for a patient to be diagnosed with fibromyalgia and some doctors still refuse to recognize it as a disease. More...
10 Apr 2018
Image: Computerized tomography (CT) scans from two different patients with pulmonary nodules. The arrow on the left points to a benign (noncancerous) nodule, while the arrow on the right shows a small lung cancer (Photo courtesy of The Lung Cancer Center at The Valley Hospital).

Liquid Biopsy Can Rule Out Early-Stage Lung Cancer

Lung nodules are a diagnostic challenge with an estimated yearly incidence of 1.6 million in the USA. The majority of these patients have benign lung nodules; however, there are significant costs, morbidity and mortality associated with the invasive biopsies needed to determine which nodules are cancerous. More...
05 Apr 2018
Image: A diagram of the approach used to evaluate urinary cells; UroSEEK assay is designed to detect urothelial neoplasms that are in direct contact with urine (Photo courtesy of Johns Hopkins Medicine).

Urinary Gene-Based Test Detects Bladder Cancer

Predominantly of urothelial histology, invasive bladder cancer (BC) arises from non-invasive papillary or flat precursors, and many BC patients suffer multiple relapses prior to progression, providing ample lead-time for early detection and treatment prior to metastasis. More...
03 Apr 2018
Image: Since fluid from the Pap test occasionally contains cells from the endometrium or ovaries, scientists found they could detect cancer cells from these organs that are present in the fluid by using different brushes (Photo courtesy of Johns Hopkins University).

Cervical Fluid Test Developed for Gynecological Cancers

Together, endometrial and ovarian cancers account for about 25,000 deaths each year and are the third leading cause of cancer-related mortality in women in the USA. Most of these deaths are caused by high-grade tumor subtypes, which tend to metastasize before the onset of symptoms. More...
03 Apr 2018
Image: The HiSeq2000 instrument used for whole-genome sequencing targeted resequencing, gene expression level detection, DNA methylation profiling, de novo sequencing, metagenomic studies, and ChiP-seq (Photo courtesy of Illumina).

Chromosome Interaction Profiling Reveals Cancer Risk Genes

Breast cancer is a heterogeneous disease with two main subtypes defined by the presence (ER+) or absence (ER−) of the estrogen receptor. Approximately 80% of newly diagnosed breast cancers are ER+ although this proportion varies with age at diagnosis and ethnicity. More...
29 Mar 2018
Image: New cutting edge technology can be used to grade cancer tumors, eradicating human subjectivity. A traditional stained H+E biopsy (L) and a Digistain view (R) (Photo courtesy of Imperial College London).

Cutting Edge Technology Used to Grade Cancer Tumors

Biopsy specimens are processed into formalin-fixed-paraffin-embedded (FFPE) blocks and currently, hematoxylin and eosin (H + E) stained sections are widely used for the histopathological diagnosis of cancer and other pathologies. More...
28 Mar 2018
Image: The NextSeq 500 benchtop sequencer delivers on-demand exome, transcriptome and whole-genome sequencing (Photo courtesy of Illumina).

Distinct Epigenetic Features Found in Alzheimer's Brains

Aging is the strongest risk factor for Alzheimer’s disease (AD), although the underlying mechanisms remain unclear though AD tends to coincide with certain chromatin shifts in the aging brain. More...
21 Mar 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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