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Pathology

Image: A histopathology of Barrett\'s esophagus, characterized by the presence of specialized columnar epithelium with goblet cells (Photo courtesy of Dr. John R Goldblum, MD).

Esophageal Cancer in Relative Increases Barrett’s Risk

Barrett's esophagus refers to an abnormal change (metaplasia) in the cells of the lower portion of the esophagus. It is characterized by the replacement of the normal stratified squamous epithelium lining of the esophagus by simple columnar epithelium with goblet cells. More...
09 Nov 2017
Image: A scanning electron photomicrograph of Streptococcus mutans; these bacteria are found in cases of infective endocarditis (Photo courtesy of Dr. David Phillips).

New Method Helps Rule Out Heart Valve Infection

If a blood sample shows the presence of what is known as alpha-streptococci, there is a risk that the person suffers from infective endocarditis, a heart valve infection and it is an inflammation of the inner tissues of the heart, the endocardium, usually of the valves. More...
08 Nov 2017
Image: The Videssa Breast is the first blood test of its kind that detects and analyzes multiple types of tumor protein biomarkers for improved cancer detection (Photo courtesy of Provista Diagnostics).

Blood Test Can Effectively Rule Out Breast Cancer

Breast density is associated with reduced imaging resolution in the detection of breast cancer. Breast density is a radiologic phenomenon that is not discernable by palpation; it is a radiologist’s assessment. Imaging rays permeate dense breast tissue in a more opaque manner, thereby reducing image resolution. More...
07 Nov 2017
Image: The ADXBLADDER MCM5 ELISA kit for the diagnosis of bladder cancer (Photo courtesy of Arquer Diagnostics).

Noninvasive Test Detects Bladder Cancer

In Europe, bladder cancer represents the fourth most common cancer in men and the 15th most common cancer in women, with 151,000 people diagnosed with the condition in 2012. In order to make a bladder cancer diagnosis, experts currently recommend cystoscopy for all patients with hematuria, in conjunction with computed tomography (CT) urography (in selected high-risk patients) or renal and bladder ultrasound. More...
07 Nov 2017
Image: The Lumipulse G CK-MB immunoassay, an aid in the diagnosis of acute myocardial infarction, being prepared to run on a LUMIPULSE G1200 instrument (Photo courtesy of Fujirebio Europe).

CK-MB Assay Used to Diagnose Acute Myocardial Infarction

Creatine Kinase (CK) is an enzyme found in high amounts in muscle tissue due to its role in muscle contraction. CK-MB is found mainly in cardiac muscle, where it comprises 15%-40% of the total CK activity, with the remainder being CK-MM. More...
07 Nov 2017
Image: An illustration of individual breast cancer tumors (Tumors A–D) with cells in varying differentiation states (shown in different colors) within a tumor (Image courtesy of Yeo SK and Guan J-L / Trends in Cancer).

Single-Cell Diagnostics Advocated for Breast Cancer Subtyping

In an opinion article based their analysis of studies, two medical researchers argue that women diagnosed with breast cancer (BC) would likely benefit from treatment based also on identifying the molecular subtype of different cells within their tumors, in addition to current molecular and histopathology testing of collections of tumor cells. More...
06 Nov 2017
Image: The Cxbladder is a non-invasive, urine-based laboratory test that is accurate, easy to use and clinically validated; it measures gene expression levels of five biomarkers that effectively rule out or detect the presence of bladder cancer (Photo courtesy of Pacific Edge).

Urine-Based Markers for Bladder Cancer Reviewed

The advances in understanding bladder cancer at the molecular and genetic level have led to the identification of detectable and measurable alterations associated with the disease. Given the ease of obtaining voided urine and its direct contact with potentially malignant urothelium, numerous urine-based tumor marker tests have been generated. More...
01 Nov 2017
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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