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Pathology

Image: A diagram of genomic and transcriptomic profiling of combined hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes (Photo courtesy of Peking University).

Genomic Analysis Uncovers Differences in Liver Cancer Subtypes

Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy arising from the liver. ICC makes up about 10% of all cholangiocarcinomas. It arises from the peripheral bile ducts within the liver parenchyma, proximal to the secondary biliary radicals. More...
05 Jun 2019
Image: A histopathology of colorectal carcinoma: an example of moderately differentiated adenocarcinoma showing complicated glandular structures in a desmoplastic stroma (Photo courtesy of the David Geffen School of Medicine at the University of California).

CtDNA Forecasts Non-Metastatic Colorectal Cancer Recurrence

Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine). Most colorectal cancers are due to old age and lifestyle factors, with only a small number of cases due to underlying genetic disorders. More...
29 May 2019
Image: Circulating tumor DNA provides treatment options for the most common ovarian cancer type (Photo courtesy of the University of Turku).

Liquid Biopsy Identifies Mutations Predicting Ovarian Cancer Treatment Response

Effective treatment of metastatic solid cancers is hampered by intrapatient heterogeneity, tumor evolution, and the paucity of representative tissue samples to guide treatment decisions. Analysis of circulating tumor DNA (ctDNA) is an approach with the potential of overcoming all three obstacles. More...
29 May 2019
Image: The integrated ferrohydrodynamic cell separation (iFCS) device that enriches circulating tumor cells (CTCs) in a tumor antigen-independent and cell size variation-inclusive manner (Photo courtesy of the University of Georgia).

Technology Developed to Capture Tumor Cells

The roles and clinical values circulating tumor cells (CTCs) are under intensive investigation, yet most studies are limited by technical challenges in the comprehensive enrichment of intact and viable CTCs with minimal white blood cell (WBC) contamination. More...
28 May 2019
Image: The RX Daytona chemistry analyzer is a compact fully automated benchtop clinical chemistry analyzer perfect for small to medium throughput laboratories (Photo courtesy of Randox Laboratories).

Urinary Biomarkers Diagnose Serious Kidney Allergic Reaction

Acute interstitial nephritis is a condition marked by inflammation and swelling of the renal tubules, the tiny portals in the kidneys where blood is filtered. As a result, the tubules cannot properly reabsorb water and useful organic substances, such as glucose and amino acids, or secrete waste products such as urea and creatinine into urine. More...
27 May 2019
Image: A lymph node with almost complete replacement by metastatic melanoma. The brown pigment is focal deposition of melanin (Photo courtesy of Gabriel Caponetti, MD).

Blood Test Measures Effectiveness of Aggressive Cancer Treatments

Blood tests that track the amount of tumor DNA can, after only one month of drug therapy, detect how well treatment is working in patients with skin cancer. In the USA, more than 7,200 individuals are expected to die from metastatic melanoma in 2019, with BRAF mutations playing a role in nearly half of such diagnoses. More...
27 May 2019
Image: A histopathology of castration-resistant prostate cancer (Photo courtesy of Andrew J. Armstrong, MD, ScM).

Genomic Data Affects Prognosis of Advanced Prostate Cancer

Heterogeneity in the genomic landscape of metastatic prostate cancer has become apparent through several comprehensive profiling efforts, but little is known about the impact of this heterogeneity on clinical outcome. More...
22 May 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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