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Pathology

Image: A micrograph of a prostate adenocarcinoma, acinar type, the most common type of prostate cancer. Needle biopsy, H&E stain (Photo courtesy of Nephron).

Urine Protein Panels Identify Prostate Cancer and Differentiate between Tumors

A noninvasive diagnostic test for prostate cancer is based on protein signatures that can differentiate patients from healthy individuals and those with aggressive tumors from those with less dangerous growths. More...
12 Jul 2016
Image: Researchers have devised a new high-resolution method for studying which genes are active in a tissue. The method can be used on all types of tissue and is valuable to both preclinical research and cancer diagnostics (Photo courtesy of the Karolinska Institutet / the Royal Institute of Technology).

Spatial Transcriptomics Technique Enables Visualization of Gene Expression in Tissues

A team of Swedish researchers has developed a high-resolution method for resolving the transcriptome – the library of active genes and RNAs – in histological samples of patients' tissues. More...
12 Jul 2016
Image: In kataegis, multiple mutations cluster in a few hotspots in a cancer genome. Here, cytosine (C) bases are commonly substituted with thymine (T) in the DNA strand (Photo courtesy of Matteo D’Antonio, University of California, San Diego).

Breast Tumors That Display Kataegis Have a Better Prognosis

Breast tumors that display kataegis, a state of hypermutation that is localized to only a few genomic regions, are not highly invasiveness, and patients with cancers that possessing this marker have a good prognosis. More...
12 Jul 2016
Image: A histopathology of a meningioma with brain invasion (WHO Grade II); the tumor (bottom/right of image) has the typical \"pushing border\" invasion into the cerebral cortex (Photo courtesy of Nephron).

High Blood Sugar Associated with Lower Risk of Benign Tumors

Meningioma, is a primary tumor arising from the membrane surrounding the brain and spinal cord, accounts for more than one-third of all primary brain and central nervous system tumors. More...
07 Jul 2016
Image: The miScript primer assays and PCR kits (Photo courtesy of Qiagen).

MicroRNAs Predict Disease Progression in Brain Tumors

A new method has been developed of predicting disease progression in glioblastoma patients who have undergone standard treatment and multimodal therapy of glioblastoma (GBM) reveals inter-individual variability in terms of treatment outcome. More...
07 Jul 2016
Image: The automated cobas 4800 platform system (Photo courtesy of Roche).

Automated Extraction of FFPE Tissue for High-Risk HPV Testing

The testing for high-risk human papillomavirus (HR-HPV) in head and neck squamous cell carcinomas is important for both prognostication and clinical management. Several testing platforms are available for HR-HPV; however, effective alternative automated approaches are needed. More...
07 Jul 2016
Image: An adult Opisthorchis viverrini or Southeast Asian liver fluke stained with carmine (Photo courtesy of the CDC).

Unsuspected Bacterial Link to Bile Duct Cancer Discovered

Bacteria in the bile duct have been identified as a potential risk factor in the development of bile duct cancer, or Cholangiocarcinoma, a rare but aggressive form of cancer with symptoms that do not present themselves at the early stages. More...
06 Jul 2016
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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