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Pathology

Image: Histopathology of a skin section from a patient with superficial spreading malignant melanoma (Photo courtesy of Profs. Leszek Wozniak and Krzysztof W. Zielinski).

Noncoding RNA Gene Linked to Malignant Melanoma

While a large share of the human genome has long been considered “junk DNA” because it does not contribute to protein coding, recent insights indicate that it does produce many noncoding ribonucleic acids that play important roles in essential biological processes and diseases.   More...
05 Apr 2016
Image: Histopathology of colon adenocarcinoma composed of chaotic glandular structures that are lined by one or more rows of cancer cells with or without mucus production (Photo courtesy of the Johns Hopkins University).

Novel Blood Test Detects Colorectal Cancer Recurrence Earlier

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide, accounting for more than 600,000 deaths each year. When diagnosed early, before cancer has spread, the relative five-year survival rate for CRC is 90%, but only about 4 out of 10 CRC cases are detected early.  More...
05 Apr 2016
Image: Schematics of the three biomarker myChoice homologous recombination deficiency (HRD) assay (Photo courtesy of Myriad Genetics).

Hereditary Cancer Test Identifies Deleterious Mutations in Endometrial Cancer

Two recent studies have shown that a Hereditary Cancer test can identify deleterious mutations in patients with endometrial cancer and additionally, showed the superior ability of the combined three biomarker test to predict survival in patients with platinum treated ovarian cancer.  More...
05 Apr 2016
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High Risk HPV Multiplex Assay Clinically Validated

Persistent infection with at least one of the high-risk carcinogenic human papillomavirus types is the primary risk factor for the development of cervical cancer and HPV is found in virtually all cases of cervical cancer and precursor lesions.  More...
04 Apr 2016
Image: Luminescent conjugated oligothiophene, h-FTAA staining of tissue showing amyloid deposits, yellow red fluorescence (Photo courtesy of Linköping University).

Sensitive Method Detects Early Amyloidosis in Humans

The amyloidoses comprise a large group of diseases characterized by extracellular deposits in various tissues and organs. These deposits, termed “amyloid,” result from misfolding and/or partial unfolding of proteins followed by their ordered aggregation into amyloid fibrils with specific β-sheet conformation.  More...
03 Apr 2016
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Novel Blood Test Developed for Alzheimer's Diagnosis

A blood test has been developed that may potentially facilitate detection of Alzheimer's disease at an early stage and it is based on an immuno-chemical analysis using an infrared sensor.   More...
30 Mar 2016
Image: Schematic diagram of circulating methylated cell free DNA (Photo courtesy of Huntsman Cancer Institute).

Multiple Diseases Detected via DNA Released from Dying Cells

A blood test has been developed that can detect multiple pathologies, including diabetes, cancer, traumatic injury and neurodegeneration, in a highly sensitive and specific manner. The novel method infers cell death in specific tissue from the methylation patterns of circulating DNA that is released by dying cells.   More...
30 Mar 2016
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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