Automated Third Generation Assay Determines Parathyroid Hormone Levels

A chemiluminescent immunoassay was released for the quantitative determination of parathyroid hormone (PTH) levels.

The new assay, dubbed Liaison1-84 PTH, determines PTH in serum and ethylenediaminetetraacetic acid (EDTA)-plasma, without cross-reactivity with the 7-84 PTH fragment.

An antibody, which is highly specific for the N-terminus of the peptide ensures 100% specificity for the whole PTH molecule and eliminates the problem of interference due to N-terminal fragments. The Liaison1-84 PTH assay is therefore able to provide uniformity of results even in patients with kidney disease, who tend to accumulate these fragments in high concentrations.

DiaSorin (Turin, Italy) added the fully automated Liaison1-84 PTH assay to its bone and mineral panel, which includes Liaison 25-OH Vitamin D Total, Liaison N-TACT PTH, Liaison BAP Ostase, and Liaison Osteocalcin. The completed panel assesses and monitors bone metabolism diseases.

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