Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Novel Biomarker Identifies Early Clinical CV Disease

By LabMedica International staff writers
Posted on 19 Jul 2017
Print article
Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality worldwide, and the economic, social, and costs associated with treating CAD are very high. The severity of coronary artery lesions has been proven to be associated with the risk of future cardiovascular events.

The role of homocysteine (Hcy) in the pathogenesis of coronary artery disease (CAD) is controversial, as decreased Hcy levels have not demonstrated consistent clinical benefits. Recent studies propose that S-adenosylhomocysteine (SAH), and not Hcy, plays a role in cardiovascular disease (CVD).

Scientists at the Tianjin Medical University General Hospital (Tianjin, China) recruited 160 hospitalized patients with chest pain, aged between 40 and 80 years between March 2016 and September 2016. Patients with atherosclerosis (AS) and CAD were confirmed by coronary angiography. After the patients had fasted overnight, for a minimum of 12 hours, venous blood samples were collected in ethylenediaminetetraacetic acid (EDTA) anticoagulation tubes before coronary angiography.

Plasma Hcy levels were estimated by enzymatic cycling methods. Plasma SAH and S-adenosylmethionine (SAM) concentrations were measured using high performance liquid chromatography (HPLC). The serum folate and serum vitamin B12 concentrations were measured using Immulite Chemiluminescent kits performed on the IMMULITE 2000 XPi analyzer. Levels of total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, creatinine, and fasting blood glucose were measured using routine methods. Low-density lipoprotein (LDL) cholesterol levels were measured using the colorimetric method.

The investigators found that SAH levels were significantly higher in the CAD group (23.09 ± 2.4 nmol/L) than in the AS group (19.2 ± 1.5 nmol/L). While the AS group had higher values for SAM/SAH (5.1 ± 0.7 versus 4.1 ± 1.1), levels of SAM, Hcy, folate, and vitamin B12 were similar in the two groups. Coronary artery lesions were associated with SAH. Plasma SAH concentrations are independently associated with coronary artery lesions among patients undergoing coronary angiography. Plasma SAH might be a novel biomarker for the early clinical identification of CVD.

The authors concluded that that the levels of plasma SAH were independently correlated with coronary lesions among patients undergoing coronary angiography. This positive association suggests that SAH may be a novel and better biomarker for the risk of coronary lesions when compared to Hcy. The study was published on July 4, 2017, in the journal Clinica Chimica Acta.

Related Links:
Tianjin Medical University General Hospital

New
Gold Member
Human Chorionic Gonadotropin Test
hCG Quantitative - R012
Verification Panels for Assay Development & QC
Seroconversion Panels
New
Fecal DNA Extraction Kit
QIAamp PowerFecal Pro DNA Kit
New
Community-Acquired Pneumonia Test
RIDA UNITY CAP Bac

Print article

Channels

Immunology

view channel
Image: The cancer stem cell test can accurately choose more effective treatments (Photo courtesy of University of Cincinnati)

Stem Cell Test Predicts Treatment Outcome for Patients with Platinum-Resistant Ovarian Cancer

Epithelial ovarian cancer frequently responds to chemotherapy initially, but eventually, the tumor develops resistance to the therapy, leading to regrowth. This resistance is partially due to the activation... Read more

Microbiology

view channel
Image: The lab-in-tube assay could improve TB diagnoses in rural or resource-limited areas (Photo courtesy of Kenny Lass/Tulane University)

Handheld Device Delivers Low-Cost TB Results in Less Than One Hour

Tuberculosis (TB) remains the deadliest infectious disease globally, affecting an estimated 10 million people annually. In 2021, about 4.2 million TB cases went undiagnosed or unreported, mainly due to... Read more

Pathology

view channel
Image: The ready-to-use DUB enzyme assay kits accelerate routine DUB activity assays without compromising data quality (Photo courtesy of Adobe Stock)

Sensitive and Specific DUB Enzyme Assay Kits Require Minimal Setup Without Substrate Preparation

Ubiquitination and deubiquitination are two important physiological processes in the ubiquitin-proteasome system, responsible for protein degradation in cells. Deubiquitinating (DUB) enzymes contain around... Read more

Technology

view channel
Image: The HIV-1 self-testing chip will be capable of selectively detecting HIV in whole blood samples (Photo courtesy of Shutterstock)

Disposable Microchip Technology Could Selectively Detect HIV in Whole Blood Samples

As of the end of 2023, approximately 40 million people globally were living with HIV, and around 630,000 individuals died from AIDS-related illnesses that same year. Despite a substantial decline in deaths... Read more

Industry

view channel
Image: The collaboration aims to leverage Oxford Nanopore\'s sequencing platform and Cepheid\'s GeneXpert system to advance the field of sequencing for infectious diseases (Photo courtesy of Cepheid)

Cepheid and Oxford Nanopore Technologies Partner on Advancing Automated Sequencing-Based Solutions

Cepheid (Sunnyvale, CA, USA), a leading molecular diagnostics company, and Oxford Nanopore Technologies (Oxford, UK), the company behind a new generation of sequencing-based molecular analysis technologies,... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.