Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Blood Test Helps Identify CV Patients Most at Risk

By LabMedica International staff writers
Posted on 19 Feb 2018
A new blood test could provide a clue as to why some patients are at higher risk of cardiovascular disease risk after suffering a heart attack, which may help scientists to identify new targets for reducing the risk and eventually lead to more effective treatments.

Adverse events, including cardiovascular (CV) death, remain common following acute coronary syndrome (ACS). Intensive antithrombotic therapies, including potent P2Y12 inhibitors and the addition of low-dose anticoagulant therapy, have all resulted in improved outcomes but increased the risk of major bleeding events.

An international team of scientists collaborating with their colleagues at the University of Sheffield (Sheffield, UK) obtained blood samples from a sub-set of 4,354 patients with acute coronary syndrome as they were discharged from hospital. High-throughput turbidimetric analysis was performed in flat-bottomed, polystyrene 96-well plates using a dedicated Multiskan FC plate reader.

Studied variables included lysis time which is time taken for turbidity to drop by 50% from maximum as a measure of lysis potential and maximum turbidity which is turbidity the scattering of light as a measure of fibrin clot density. Other biochemical analyses included N-terminal pro B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T, cystatin C, C-reactive protein (CRP), and growth differentiation factor-15 (GDF-15), which were measured using sandwich immunoassays. Differential blood count was determined on EDTA-anticoagulated blood samples at randomization.

The scientists reported that after adjusting for CV risk factors, each 50% increase in lysis time was associated with CV death/spontaneous myocardial infarction (MI) and CV death alone. Similarly, each 50% increase in maximum turbidity was associated with increased risk of CV death. After adjustment for other prognostic biomarkers (leukocyte count, high-sensitivity C-reactive protein, high-sensitivity troponin T, cystatin C, N-terminal pro B-type natriuretic peptide, and growth differentiation factor-15), the association with CV death remained significant for lysis time, but not for maximum turbidity.

The authors concluded that after adjustment for known clinical characteristics and risk factors, the study found that the patients with the longest clot lysis time had a 40% increased risk of recurrent myocardial infarction or death due to cardiovascular disease. Fibrin clots that are resistant to lysis independently predict adverse outcome in ACS patients. The study was published on January 29, 2018, in the European Heart Journal.

Related Links:
University of Sheffield


Gold Member
Antipsychotic TDM Assays
Saladax Antipsychotic Assays
Verification Panels for Assay Development & QC
Seroconversion Panels
New
Malaria Test
STANDARD Q Malaria P.f/Pan Ag
New
Respiratory QC Panel
Assayed Respiratory Control Panel
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get complete access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Molecular Diagnostics

view channel
Image: The experimental blood test accurately indicates severity and predicts potential recovery from spinal cord injury (Photo courtesy of 123RF)

Blood Test Identifies Multiple Biomarkers for Rapid Diagnosis of Spinal Cord Injury

The National Institutes of Health estimates that 18,000 individuals in the United States sustain spinal cord injuries (SCIs) annually, resulting in a staggering financial burden of over USD 9.... Read more

Immunology

view channel
Image: The findings were based on patients from the ADAURA clinical trial of the targeted therapy osimertinib for patients with NSCLC with EGFR-activated mutations (Photo courtesy of YSM Multimedia Team)

Post-Treatment Blood Test Could Inform Future Cancer Therapy Decisions

In the ongoing advancement of personalized medicine, a new study has provided evidence supporting the use of a tool that detects cancer-derived molecules in the blood of lung cancer patients years after... Read more

Microbiology

view channel
Image: Schematic representation illustrating the key findings of the study (Photo courtesy of UNIST)

Breakthrough Diagnostic Technology Identifies Bacterial Infections with Almost 100% Accuracy within Three Hours

Rapid and precise identification of pathogenic microbes in patient samples is essential for the effective treatment of acute infectious diseases, such as sepsis. The fluorescence in situ hybridization... Read more

Industry

view channel
Image: Tumor-associated macrophages visualized using the Multiomic LS Assay (Photo courtesy of ACD)

Leica Biosystems and Bio-Techne Expand Spatial Multiomic Collaboration

Bio-Techne Corporation (Minneapolis, MN, USA) has expanded the longstanding partnership between its spatial biology brand, Advanced Cell Diagnostics (ACD, Newark, CA, USA), and Leica Biosystems (Nussloch,... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.