Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




Saliva Test Could Aid Early Detection of Ectopic Pregnancy

By LabMedica International staff writers
Posted on 12 Oct 2023

Ectopic pregnancy, also known as extrauterine pregnancy (EP), happens when a fertilized egg attaches and grows outside the uterus. More...

This condition poses significant risks to the mother's health and life. Currently, ultrasonography is the primary way to diagnose an EP, but it's not an early detection method. Due to the lack of timely diagnosis, women face elevated health risks. Researchers have been exploring the possibility of using pathological or molecular markers for early detection, which could be a game-changer in clinical diagnosis and treatment. In the latest effort, a study investigated whether salivary proteins could serve as potential biomarkers for identifying EP, using gel-based protein mass spectrometry.

Researchers at RNT Medical College (Rajasthan, India) focused on proteins in saliva that could become selectively elevated in EP. For the analysis, they used gel-based protein separation followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify the proteins. The researchers found 326 different proteins in the saliva samples they examined. Interestingly, 101 of these proteins were exclusively present in the saliva of patients with ruptured EP. Many of these proteins are associated with defense mechanisms, such as the innate immune system, neutrophil degranulation, interactions with the blood vessel wall, and activation of the nuclear factor kB (NF-kB) pathway.

These initial findings indicate that certain salivary proteins, like Complement C4-B, Plasminogen Activator Inhibitor 2 and 1, and Glutathione S-transferase omega-1, could serve as promising biomarkers for EP. These proteins have also been found to play a role in other reproductive issues and may be relevant to EP as well. Further research is currently underway to better understand the diagnostic potential and specificity of these salivary proteins in relation to EP.

Related Links:
RNT Medical College


New
Gold Member
Cardiovascular Risk Test
Metabolic Syndrome Array I & II
Collection and Transport System
PurSafe Plus®
New
Autoimmune Liver Diseases Assay
Microblot-Array Liver Profile Kit
New
8-Channel Pipette
SAPPHIRE 20–300 µL
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: New research points to protecting blood during radiation therapy (Photo courtesy of 123RF)

Pioneering Model Measures Radiation Exposure in Blood for Precise Cancer Treatments

Scientists have long focused on protecting organs near tumors during radiotherapy, but blood — a vital, circulating tissue — has largely been excluded from dose calculations. Each blood cell passing through... Read more

Pathology

view channel
Image: Erythrocyte Sedimentation Rate Sample Stability (Photo courtesy of ALCOR Scientific)

ESR Testing Breakthrough Extends Blood Sample Stability from 4 to 28 Hours

Erythrocyte sedimentation rate (ESR) is one of the most widely ordered blood tests worldwide, helping clinicians detect and monitor infections, autoimmune conditions, cancers, and other diseases.... Read more

Technology

view channel
Image: Conceptual design of the CORAL capsule for microbial sampling in the small intestine (H. Mohammed et al., Device (2025). DOI: 10.1016/j.device.2025.100904)

Coral-Inspired Capsule Samples Hidden Bacteria from Small Intestine

The gut microbiome has been linked to conditions ranging from immune disorders to mental health, yet conventional stool tests often fail to capture bacterial populations in the small intestine.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.