We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




SIP1 Protein Expression Indicates Poor Prognosis in Pharyngeal Cancer

By LabMedica International staff writers
Posted on 01 Dec 2014
Print article
Image: A tissue micro arraying instrument (Photo courtesy of Beecher Instruments).
Image: A tissue micro arraying instrument (Photo courtesy of Beecher Instruments).
The expression of the Smad interacting protein 1 (SIP1) in pharyngeal squamous cell carcinoma tumors often indicates an advanced tumor stage, a high risk of recurrence and a poor prognosis.

Although pharyngeal squamous cell carcinoma (PSCC) is a rather rare disease, its incidence has been increasing over the past three decades, now accounting for 130,000 new cases and 80,000 cancer deaths worldwide and the prognosis is one of the poorest of all the head and neck squamous cell carcinomas.

A scientist at the University of Eastern Finland assessed the role of Epithelial-mesenchymal transition (EMT)-related transcription factors in PSCC. The immunohistochemical expressions of transcription factors SNAI1, TWIST, SIP1, SLUG and ZEB1 were analyzed in tumor cells, stromal and endothelial cell nuclei, as well as in cytoplasm of PSCC samples in an effort to evaluate the association of their expressions with clinicopathological variables and patient prognosis.

Sufficient material for tissue microarrays and immunohistochemical analyses were available from 110 original tumor samples for SNAI1 staining, 109 for TWIST staining and 108 for SIP1, ZEB1 and SLUG staining. The two most representative areas of the paraffin-embedded tissue blocks were chosen by an experienced pathologist and marked for microarrays which were constructed using 1.0 mm core Manual tissue arrayer I (Beecher Instruments, Silver Spring, MD, USA).

The tumors with positive epithelial nucleal SIP1 immunostaining were more advanced and had more lymph node metastases. The expression of SIP1 was also linked to poorer disease-specific five-year survival and was an independent prognostic factor in multivariate analysis together with tumor size and general patient status. SNAI1 expression in endothelial cells predicted reduced survival and increased tumor size, whereas TWIST expression in stromal cells was linked to higher risk of recurrence.

The co-expression of SNAI1, TWIST, and SIP1 in tumor epithelial cell nuclei predicted poorer prognosis than SIP1 expression alone. The author, Dr. Anna Jouppila-Matto, MD, PhD, presented the results in her doctoral thesis and concluded that SIP1 is a potential new prognostic factor for clinical use, helping to single out patients with more aggressive tumor behavior requiring more intensive therapy and closer follow-up.

Related Links:

University of Eastern Finland 
Beecher Instruments 


Gold Member
C-Reactive Protein Reagent
CRP Ultra Wide Range Reagent Kit
Automated Blood Typing System
IH-500 NEXT
New
Centrifuge
Centrifuge 5430/ 5430 R
New
Toxoplasma Gondii Test
Toxo IgG ELISA Kit

Print article

Channels

Clinical Chemistry

view channel
Image: The new saliva-based test for heart failure measures two biomarkers in about 15 minutes (Photo courtesy of Trey Pittman)

POC Saliva Testing Device Predicts Heart Failure in 15 Minutes

Heart failure is a serious condition where the heart muscle is unable to pump sufficient oxygen-rich blood throughout the body. It ranks as a major cause of death globally and is particularly fatal for... Read more

Hematology

view channel
Image: The smartphone technology measures blood hemoglobin levels from a digital photo of the inner eyelid (Photo courtesy of Purdue University)

First-Of-Its-Kind Smartphone Technology Noninvasively Measures Blood Hemoglobin Levels at POC

Blood hemoglobin tests are among the most frequently conducted blood tests, as hemoglobin levels can provide vital insights into various health conditions. However, traditional tests are often underutilized... Read more

Immunology

view channel
Image: Under a microscope, DNA repair is visible as bright green spots (“foci”) in the blue-stained cell DNA. Orange highlights actively growing cancer cells (Photo courtesy of WEHI)

Simple Blood Test Could Detect Drug Resistance in Ovarian Cancer Patients

Every year, hundreds of thousands of women across the world are diagnosed with ovarian and breast cancer. PARP inhibitors (PARPi) therapy has been a major advancement in treating these cancers, particularly... Read more

Microbiology

view channel
Image: HNL Dimer can be a novel and potentially useful clinical tool in antibiotic stewardship in sepsis (Photo courtesy of Shutterstock)

Unique Blood Biomarker Shown to Effectively Monitor Sepsis Treatment

Sepsis remains a growing problem across the world, linked to high rates of mortality and morbidity. Timely and accurate diagnosis, along with effective supportive therapy, is essential in reducing sepsis-related... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.