New Nanomechanical Technique for Fast, One-Step, Immune-Affinity Tests Rapidly Quantifies Transmissibility of COVID-19 Variants

A team of researchers has developed a new nanomechanical technique for fast, one-step, immune-affinity tests, which can quantify the immune response induced by different COVID-19 variants in serum.

The technique developed by researchers at Trinity College Dublin (Dublin, Ireland) provides a new tool for tracking infection immunity over time and for analysing new vaccine candidates. The team’s specific quantitative assay enables direct classification of variant-binding properties for screening emerging variants. The major advantage of the newly developed technique with respect to (existing, commonly used) ELISA tests is that while it is equally sensitive – with added single amino-acid resolution – and able to directly detect multiple variants by in situ differential analysis, it can also do so in a mere fraction of the time.

The researchers focused on COVID-19 variants of concern and their generated humoral immune response. Humoral immunity is an antibody-mediated response that occurs when foreign material is detected in the body. Given that the COVID-19 virus has developed substantial mutations in the spike protein, this can undermine the efficacy of current vaccines and monoclonal antibody therapies. The new technology developed by team of researchers can assist vaccine development studies in phase 1-3, with focus on comparing protection patterns and analyzing novel vaccine candidates.

“Our measurements match the statistical analysis of, for example, the transmissibility of the alpha-variant that can otherwise only be gained by analyzing the development of the disease proliferation within a population over weeks. We believe that this new technology can improve and speed up the public health guidance process,” said Professor Martin Hegner, Principal Investigator in the Trinity Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) and Trinity’s School of Physics. “The direct technique greatly simplifies the preparation protocol that in ELISA includes many washings and waiting steps, hence reducing the amount of consumables needed and thus the relative cost. It will therefore be well suited to use in emergency situations.”

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