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BioResearch

Image: A structural model of Bfl-1 (light blue ribbon with yellow stick representing a sulfur atom) in complex with the inhibitor 130G4 (green ribbon with red, oxygen, and blue, nitrogen, sticks). The bond between the Bfl-1 sulfur atom (yellow) and 130G4 is highlighted by a magenta stick (Photo courtesy of Pellecchia laboratory, University of California, Riverside).

Development of Anti-Cancer Drugs May Overlook Compounds Useful for Humans

A large proportion of cancer research is done with mouse models; however a recent paper suggested that differences between the mouse and human genomes may lead to promising approaches to curing the disease in humans being overlooked. More...
21 Dec 2016
Image: Cells that express exon 6-truncated p53 protein exhibit structural features that reflect their reprogramming away from stability and toward proliferation and metastasis. This was apparent when comparing cells that do not express the truncated form of the protein (left column) with those that do (right column). The two images at the top are composites, with blue indicating DNA (i.e., cell nuclei); and green and red corresponding, respectively, with the proteins actin and e-cadherin. In the cells reprogrammed by truncated p53 proteins, actin fibers (middle image) show stress, while the signal from e-cadherin \"glue\" drops out altogether (bottom image). These cells are much more likely to break away from tissue and travel in the body (Photo courtesy of Sordella Laboratory, Cold Spring Harbor Laboratory).

Shortened p53 Protein Promotes Tumor Growth by Modulating Mitochondrial Function

A shortened version of the p53 protein - caused by a mutation in the TP53 tumor suppressor gene – has been found to promote rather than impede tumor growth. More...
20 Dec 2016
Image: A crystal structure of the PodA protein complex with three molecules of 1-hydroxyphenazine, the reaction product, bound in the active sites (Photo courtesy of Kyle Costa, California Institute of Technology).

Enzymatic Degradation of Pyocyanin Blocks Pseudomonas Biofilm Formation

An enzyme isolated from the soil bacterium Mycobacterium fortuitum was found to prevent biofilm formation by the aggressively pathogenic Gram-negative bacterium Pseudomonas aeruginosa. More...
20 Dec 2016
Image: A fluorescent micrograph showing detection of Salmonella (red) in macrophages (green) and other immune cells in the ventricles of the brain of a mouse orally fed Salmonella. Salmonella-infected areas were associated with an increase of cells (blue nucleus) in the ventricles and meninges of the brain, a hallmark of bacterial meningitis (Photo courtesy of the [U.S.] National Institute of Allergy and Infectious Diseases).

Mouse Study Identifies Molecular Mechanism behind Bacterial Meningitis

A team of molecular microbiologists examined the ability of the bacterium Salmonella enterica serovar Typhimurium to infect the central nervous system and cause meningitis following the natural route of infection in mice. More...
20 Dec 2016
Image: A micrograph of bone marrow aspirate showing the histologic correlate of multiple myeloma (Photo courtesy of Wikimedia Commons).

Proteasome Inhibitor Treatment Repairs Effects of Ribosomal Damage in Multiple Myeloma

A recent paper suggested that severity of a type of multiple myeloma characterized by a deletion from the genome that caused dysfunction of ribosome function could be reduced by treatment with a proteasome inhibitor. More...
20 Dec 2016
Image: An artist\'s conception illustrating the early stages of an influenza infection and showing what happens after the influenza viruses enter the human body (Photo courtesy of the CDC).

Influenza Virus Proteins Block Host Cell Interference with RNA Defense Mechanism

To overcome infection by influenza A virus (IAV), host cells must generate a specific class of short interfering RNA (siRNA), an undertaking actively inhibited by the virus. More...
15 Dec 2016
Image: Human kidney cells stained with a P-body marker (red) and NoBody (green). Yellow dots are where P-bodies and NoBody interact. Cell nuclei are shown in blue (Photo courtesy of Yale University).

Novel Microprotein Functions in Messenger RNA Removal Complex

A novel "microprotein" has been identified and shown to fulfill a cellular maintenance function by prepping nonessential messenger RNA (mRNA) for destruction and removal from the cytoplasm. More...
15 Dec 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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