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Clinical Chemistry

Image: The Agilent Cary 60 UV-Vis Spectrophotometer is efficient, accurate and flexible, and is designed to meet immediate and future challenges (Photo courtesy of Agilent Technologies).

Automated Enzymatic Method Quantifies Pyruvate Kinase in Erythrocytes

 A deficiency of red blood cell (RBC) pyruvate kinase (PK), inherited as an autosomal recessive trait, is the most common cause of hereditary nonspherocytic hemolytic anemia (HSHA). The hemolysis is owing to the inability of the PK-deficient RBCs to maintain adequate quantities of ATP. More...
05 Mar 2020
Image: Biochemical thyroid screening is recommended as part of routine management for type 1 and type 2 diabetes (Photo courtesy of Alzyme).

Regular Thyroid Testing Recommended Regardless of Diabetes Type

 Thyroid dysfunction is common among people with diabetes regardless of type, suggesting that biochemical thyroid screening should be a part of routine management for those with type 1 and type 2. A recent study has determined the prevalence and incidence of thyroid dysfunction in type 1 diabetes, type 2 diabetes and latent autoimmune diabetes of adults. More...
05 Mar 2020
Image: The AU640 chemistry analyzer is an ideal primary clinical chemistry analyzer for low- to mid-volume hospitals and laboratories (Photo courtesy of Beckman Coulter).

Glucose Point-of-Care Measurements Evaluated for Gestational Diabetes

 Gestational diabetes is a condition in which a woman without diabetes develops high blood sugar levels during pregnancy. Gestational diabetes generally results in few symptoms; however, it does increase the risk of pre-eclampsia, depression, and requiring a Caesarean section. More...
04 Mar 2020
Image: Serum folate and B vitamins should be tested in certain patients than are being hospitalized (Photo courtesy of Toliopoulos Diagnostics/Roche).

Low Folate Levels Can Indicate Malnutrition in Hospital Patients

 Folate deficiency, also known as vitamin B9 deficiency, is a low level of folate and derivatives in the body. Signs of folate deficiency are often subtle. A low number of red blood cells (anemia) are a late finding in folate deficiency and folate deficiency anemia is the term given for this medical condition. More...
04 Mar 2020
Image: The Variant II Turbo Hemoglobin Testing System combines High Performance Liquid Chromatography (HPLC) precise and variant detection with fast throughput to provide a comprehensive solution for HbA1c testing (Photo courtesy of Bio-Rad).

Monogenic Hypercholesterolemia Increases Cardiovascular Disease Risk

 Monogenic familial hypercholesterolemia (FH) is associated with lifelong elevations in low-density lipoprotein cholesterol (LDL-C) levels and increased risk of atherosclerotic cardiovascular disease (CVD). More...
03 Mar 2020
Image: The penKid assay allows the measurement of actual kidney function with a simple blood draw. Being non-inferior to the gold standard, rising and decreasing penKid values reveal worsening and improving of kidney function independent from inflammation or any other comorbidity, allowing the inclusion of all critical ill patients (Photo courtesy of SphingoTec GmbH).

Proenkephalin Assesses True Glomerular Filtration Rate Accurately

 The assessment of renal function in clinical practice remains challenging. Using creatinine to assess the glomerular filtration rate (GFR) is notoriously inaccurate, and determination of the true GFR, such as using inulin or iohexol, is laborious and not feasible in daily practice. More...
02 Mar 2020
Image: The Quanterix SR-X Ultra-Sensitive Biomarker Detection System uses single molecular array technology (SIMOA) (Photo courtesy of Quanterix Corporation).

Blood Biomarkers Associated with Acute Sport-Related Concussion

 During the past decade, several candidate biomarkers have emerged as potential diagnostic markers of traumatic brain injury (TBI) and an estimated 90% of brain injuries are classified as mild TBI. More...
27 Feb 2020
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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