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Clinical Chemistry

Image: The glycated hemoglobin (HbA1c) blood test gives an average level of blood sugar over the past two to three months (Photo courtesy of HealthEngine).

High HbA1c Levels Do Not Always Lead to Diabetes

Prediabetes is an asymptomatic condition preceding type 2 diabetes. It is characterized by hyperglycemia, which is defined as a blood glucose level that is higher than normal but below the level for a clinical diagnosis of diabetes. More...
25 Jul 2019
Image: A histopathology of nodular glomerulosclerosis in a patient with long-standing diabetes mellitus. Note the markedly thickened arteriole at the lower right, which is typical for the hyaline arteriolosclerosis that is seen in diabetic kidneys as well (Photo courtesy of University of Utah).

Collagen Biomarkers Clarify Prognosis of Diabetic Renal Complications

Type 1 diabetes, once known as juvenile diabetes or insulin-dependent diabetes, is a chronic condition in which the pancreas produces little or no insulin. Insulin is a hormone needed to allow sugar (glucose) to enter cells to produce energy. More...
24 Jul 2019
Image: The ABL800 FLEX blood gas analyzer (Photo courtesy of Radiometer Medical).

Neutrophil‐Lymphocyte Ratio and Lactate Predict Mortality in Septic Patients

Sepsis is the primary cause of death from infection. It is also one of the leading causes of intensive care unit (ICU) mortality, despite early administration of antibiotics and hemodynamic management. More...
23 Jul 2019
Image: The BD Barricor tube is a single-use, plastic evacuated tube with a mechanical separator used to collect, separate, transport and process venous blood specimens (Photo courtesy of Becton, Dickinson and Company).

Samples Quality Improved Using Low-Vacuum Tubes

Centrifugation is a time consuming step, which contributes to increase the turnaround time (TAT) in laboratories, likewise hemolyzed samples that needs a re-sampling could delay management of patients. More...
16 Jul 2019
Image: A photomicrograph of an unstained, formalin preserved stool specimen mount, revealed the presence of a Paragonimus westermani trematode egg. Human infections of this lung fluke are most common in eastern Asia and in South America (Photo courtesy of the CDC).

Antibody Tests Recommended for Parasitic Infection Diagnosis

Pleural parasitic infestation (PPI) is a disease prevalent in certain parts of the world and it is frequently misdiagnosed due to its lack of standardized diagnostic criteria. The clinical manifestations are non-specific and many patients are initially treated for tuberculosis or misdiagnosed as lung cancer. More...
16 Jul 2019
Image: A bone marrow aspirate from a patient suffering from Hemophagocytic Lymphohistiocytosis showing a macrophage that has ingested a nucleated red cell (Photo courtesy of UF).

Dengue Infection Complicated by Hyperinflammatory Condition

The global incidence of dengue infection has grown dramatically and been estimated to 390 million infections yearly. This mosquito-borne virus infection occasionally develops into a potentially lethal state called severe dengue (SD). More...
11 Jul 2019

Confirmation Testing for Primary Hyperaldosteronism Remains Essential

Primary aldosteronism, also known as primary hyperaldosteronism (PHA) or Conn's syndrome, refers to the excess production of the hormone aldosterone from the adrenal glands, resulting in low renin levels. This abnormality is caused by hyperplasia or tumors. More...
10 Jul 2019
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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