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Clinical Chemistry

Image: The V-PLEX Aβ Peptide Panel 1 (6E10) Kit (Photo courtesy of Meso Scale Discovery).

Diagnostic Process Detects Alzheimer’s Years before Symptoms Appear

Alzheimer's disease (AD) pathology is accompanied by misfolding of amyloid-β (Aβ) and tau from monomeric into β-sheet–enriched pathogenic species. This process is suggested to precede about 10 to 15 years before clinical onset of the disease. More...
23 May 2019
Image: The TOSOH G8 ion exchange high performance liquid chromatography analyzer (Photo courtesy of Tosoh Bioscience).

Lower HbA1c Levels Seen in Diabetic Liver Disease Patients

Diabetes is a leading cause of liver disease, with cirrhosis responsible for a considerable number of deaths in people with diabetes in the USA. The association is mediated by multiple mechanisms including dyslipidemia and altered hepatic fatty acid processing. More...
23 May 2019
Image: Knee osteoarthritis, also known as degenerative joint disease, is typically the result of wear and tear and progressive loss of articular cartilage (Photo courtesy of Bruce Blaus).

Biomarkers Predict Total Joint Replacements in Osteoarthritis Patients

Osteoarthritis (OA) in major joints ultimately leads to joint failure for which the only curative treatment is total joint replacement. This procedure is associated with risk of complications and approximately 20% continue to experience pain. More...
22 May 2019
Image: The INNOTEST PHOSPHO-TAU(181P) is a solid-phase enzyme immunoassay for the quantitative determination of phosphorylated Tau (Phospho-Tau(181P)) in human cerebrospinal fluid (CSF) (Photo courtesy of Fujirebio).

Primary Fatty Amides Produce Blood Test for Alzheimer Disease

Neurodegenerative dementias are characterized by a progressive decline in cognitive function and memory performance. Alzheimer's disease (AD) is the most common of the neurodegenerative dementias making it a major source of global morbidity and mortality. More...
21 May 2019
Image: The ARCHITECT i2000SR immunoassay analyzer (Photo courtesy of Abbott).

Blood Test May Predict Cardiovascular Disease

According to the latest statistics from the American Heart Association (AHA), almost half of the people living in the USA have some form of cardiovascular disease. In fact, according to 2016 figures, 121.5 million adults in the USA, or 48% of the entire population, have cardiovascular disease (CVD), which is a cluster of conditions that includes hypertension. More...
16 May 2019
Assessment of LDL cholesterol levels in two patients (Photo courtesy of Randox).

Randox Unveils an Assay for the Rapid Measurement of Small Dense LDL Cholesterol (sdLDL-C)

A kit for the automated measurement of small dense low-density lipoprotein cholesterol (sdLDL-C) is now available with dedicated controls and calibrators available and instrument-specific applications for use with a wide range of biochemistry analyzers. More...
13 May 2019
Image: Nodular glomerulosclerosis in the kidney of a patient with diabetic nephropathy; the acellular light purple areas within the capillary tufts are the destructive mesangial matrix deposits (Photo courtesy of the CDC).

Blood Protein Signature Reported for Diabetic Kidney Disease

Diabetic nephropathy or diabetic kidney disease (DKD), is a result of vascular abnormalities that accompany diabetes and increases mortality risk. Furthermore, diabetes mellitus is a main risk factor for end-stage renal disease, the most advanced stage of kidney disease. More...
09 May 2019
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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