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Clinical Chemistry

Image: An ion trap mass spectrometer and high performance liquid chromatography system (Photo courtesy of Kermit Murray).

Depression Linked to Reduced Arginine Levels

Arginine is an amino acid which the body uses to produce, for example nitric oxide. Nitric oxide, in turn, is a nervous system and immune defense mediator, and it also plays a role in vascular regulation. More...
06 Mar 2018
Image: The DTX 880 multimode detector and fluorescence microplate reader (Photo courtesy of Beckman Coulter).

Enzymatic Assay Developed for Ether Phospholipids in Plasma

Ethanolamine ether phospholipid (ePE) and choline ether phospholipid (ePC) are found in human plasma (serum), but the relative concentration of the ether phospholipids in the phospholipids of human serum are very low as compared to those in tissues such as leukocytes and erythrocytes. More...
05 Mar 2018
Image: The Orbitrap Fusion Lumos Tribrid Mass Spectrometer (Photo courtesy of Thermo Fisher Scientific).

Mass Spectrometer Test Developed for Multiple Myeloma

The M-proteins are established markers for plasma cell disorders including multiple myeloma and are a key analyte for diagnosis and management of that disease. Electrophoresis-based assays are commonly used to measure levels of these proteins, with higher levels indicating a higher disease burden, but such techniques are fairly time consuming and not highly sensitive. More...
03 Mar 2018
Image: Blood samples used to assess traumatic brain injury using the Brain Trauma Indicator test (Photo courtesy of Banyan Biomarkers).

Blood Test Approved for Adult Traumatic Brain Injury

In 2013, there were approximately 2.8 million traumatic brain injuries (TBI)-related emergency department visits, hospitalizations and deaths in the USA. Of these cases, TBI contributed to the deaths of nearly 50,000 people. More...
01 Mar 2018
Image: Rings of Plasmodium falciparum in a stained thin blood smear (Photo courtesy of the CDC).

AKI Biomarker Described for Pediatric Malaria

Acute kidney injury (AKI) is an important complication in severe malaria that is associated with increased mortality in both pediatric and adult populations. However, until recently, the incidence of AKI in pediatric malaria was under-appreciated as few children develop signs of overt renal failure and creatinine testing is not routinely available in resource-constrained settings. More...
28 Feb 2018
Image: A Matrix-Assisted Laser Desorption/Ionization (MALDI) time-of-flight mass spectrometer (Photo courtesy of JEOL).

Plasma Markers Predict Brain Amyloid Burden in AD

Aggregation and accumulation of beta-amyloid (Aβ), particularly Aβ42, is implicated in the pathogenesis of Alzheimer's disease (AD) with overproduction in autosomal-dominant AD and impaired clearance in the presence of amyloidosis contributing to the cause of AD. More...
23 Feb 2018
Image: The Nephelometer analyzer BN II (Photo courtesy of Siemens Healthcare).

C-Reactive Protein Assessed for Albuminuria Severity

Diabetes is a major cause of early morbidity and mortality in the world and is the leading cause of renal failure, non-traumatic amputations and blindness in adults. Chronic hyperglycemia causes irreversible structural and functional changes in cells leading to the development of microvascular and macrovascular complications. More...
21 Feb 2018
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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