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Clinical Chemistry

Image: Research shows analyzing cortisol levels in hair close to the scalp may be a reliable diagnostic method for Cushing\'s syndrome (Photo courtesy of Professor Antonella Tosti, MD).

Hair Analysis May Help Diagnose Cushing Syndrome

Cushing's syndrome is a condition that occurs as a result of exposure to high levels of cortisol for an extended period. The diagnosis of Cushing syndrome is often difficult and time-consuming, requiring 24 hours to analyze blood and urine tests, brain imaging tests, and tissue samples from sinuses at the base of the skull. More...
23 Feb 2017
Image: The Simoa HD-1 ultrasensitive immunoassay platform (Photo courtesy of Quanterix).

Blood Test Differentiates Parkinson's from Similar Diseases

In early stages of disease, it can be difficult to differentiate between Parkinson's disease and atypical parkinsonism disorders (APDs) like multiple system atrophy, progressive supranuclear palsy and corticobasal degeneration, because symptoms can overlap. More...
22 Feb 2017
Image: A diagram of the assay to diagnose schizophrenia from a serum sample (Photo courtesy of the University of Maryland).

Blood Test Could Diagnose Schizophrenia and Other Disorders

Schizophrenia is a chronic, severe mental disorder that affects approximately 1% of the adult population in the USA and influences how a person thinks, feels, and behaves. The onset of symptoms usually begins between ages 16 and 30. Symptoms can range from visual and auditory hallucinations and movement disorders to difficulty beginning and sustaining activities. More...
22 Feb 2017
Image: A structural model of serum albumin (Photo courtesy of Wikimedia Commons).

Study Shows Varied Results from Different Methods of Measuring Albumin

A recent paper compared the accuracy of several different methods for determining levels of serum or plasma albumin, measurements, which are used to evaluate the nutritional status, kidney function, and fluid balance of dialysis patients. More...
21 Feb 2017
Image: The Dade Behring BN II automated nephelometer system (Photo courtesy of Siemens Healthcare).

Low Levels of Klothos Linked to Kidney Function Decline

The kidney has the highest levels of klotho expression and is likely the major source of soluble klotho and not surprisingly, therefore, levels of klotho tend to be low in patients with kidney disease. More...
15 Feb 2017
Image: The SEEKER workstation, a high throughput laboratory solution that measures enzymatic activity from dried blood spot specimens (Photo courtesy of Baebies).

Screening System Detects Four Metabolic Disorders

Lysosomal Storage Disorders (LSDs) are a group of rare, inherited metabolic disorders in which enzymes (proteins) that normally eliminate unwanted substances in the body’s cells are not at normal levels or functioning properly. If not detected and treated in a timely manner, these disorders may cause organ damage, neurological disability or death. More...
15 Feb 2017
Image: Small, dense LDL particles have less anti-oxidants and are associated with a much higher risk of atherosclerosis. Large, buoyant LDL particles are rich in anti-oxidants and present a much lower risk of oxidizing than the small, dense LDLs (Photo courtesy of Dr. David Jockers).

Increased Triglyceride Content Associated with Plasma Lipoprotein Lipase

Non-fasting plasma triglyceride (TG) reflect a higher risk for cardiovascular disease (CVD) than TG in the fasting plasma and this the postprandial increase of TG is the most common form of hyperlipidemia which is associated with increased remnant lipoproteins (RLP) as a risk factor for CVD. More...
15 Feb 2017
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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