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Clinical Chemistry

Image: Histopathology of pediatric non-alcoholic fatty liver disease (NAFLD This trichrome stain illustrates zone 1 steatosis, portal fibrosis, and a ductular reaction, which characterize pediatric NAFLD (Photo courtesy of Elizabeth M. Brunt MD)

Serum Antinuclear Antibody Correlated in Hispanic Pediatric Patients With NFLD

Non-alcoholic fatty liver disease (NAFLD), also known as metabolic (dysfunction) associated fatty liver disease (MAFLD), is excessive fat build-up in the liver without another clear cause such as alcohol use. Obesity and type 2 diabetes are strong risk factors for NAFLD. More...
06 Apr 2022
Image: Simoa HD-X Analyzer has a single molecule array platform (Photo courtesy of Quanterix)

Pre-Analytical Stability of Serum Biomarkers for Neurological Disease Investigated

Blood-based biomarkers are gaining increasing attention in the clinical field of neurological diseases, as they could contribute to accurate monitoring and prediction of disease and treatment outcomes. More...
01 Apr 2022
Image: Midlife lipid and glucose levels are associated with Alzheimer\'s disease (Photo courtesy of Stanford Blood Center)

Midlife Lipid and Glucose Levels Are Associated With Alzheimer's Disease

Alzheimer's disease (AD) is the fifth leading cause of death among Americans 65 years of age or older, with a prevalence of 5.8 million cases. This number is projected to nearly triple to 14 million people by 2060. More...
30 Mar 2022
Image: Liver biopsy: High magnification photomicrograph of ground glass hepatocytes, as seen in a chronic hepatitis B infection with a high viral load (Photo courtesy of Nephron)

Albumin-Related Ratios Investigated in HBV-Associated Decompensated Cirrhosis

Identification of effective and accurate prognostic biomarkers for hepatitis B virus-associated decompensated cirrhosis (HBV-DeCi) is challenging. This study was designed to determine and compare the prognostic value of albumin-related ratios (blood urea nitrogen-to-albumin ratio [BAR], C-reactive protein-to-albumin ratio [CAR], prothrombin time-international normalized ratio-to-albumin ratio [PTAR], neutrophil count-to-albumin ratio [NAR], and D-dimer-to-albumin ratio [DAR]) in HBV-DeCi patients. More...
25 Mar 2022
Image: In patients with psoriatic disease, cTnI may reflect the burden of atherosclerosis, independent of traditional cardiovascular risk factors (Photo courtesy of Cardiology Advisor)

Biomarkers Associated With Cardiovascular Outcomes in Psoriatic Patients

In patients with psoriatic disease (PsD), we determined whether cardiac troponin I (cTnI) and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) were associated with carotid plaque burden and the development of cardiovascular (CV) events independent of the Framingham Risk Score (FRS). More...
22 Mar 2022
Image: Low levels of folate (vitamin B9) in the blood may be linked to a heightened risk of dementia and death from any cause in older people (Photo courtesy of Regional Neurological Associates)

Serum Folate Deficiency in Older People Associated With Heightened Dementia

Low levels of folate (vitamin B9) in the blood may be linked to a heightened risk of dementia and death from any cause in older people, More...
21 Mar 2022
Image: The NanoSight NS300 utilizes the latest version of NanoSight’s particle characterization technology, Nanoparticle Tracking Analysis (NTA) (Photo courtesy of University of New South Wales)

Serum Extracellular Vesicle Arginase 1 Measured In T2DM

Serum extracellular vesicle (EV)-derived arginase 1 (ARG 1) plays a critical role in diabetes-associated endothelial dysfunction. This study was performed to determine the levels of serum EV-derived ARG 1 in T2DM and non-T2DM participants and to examine the association of serum EV-derived ARG 1 with T2DM incidence. More...
18 Mar 2022
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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