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Molecular Diagnostics

Image: Schematics of how the Signatera bespoke mPCR NGS assay works (Photo courtesy of Natera)

CtDNA Analysis Assesses Early Relapse Detection in Colorectal Cancer

Colorectal cancer (CRC) is a type of cancer that begins in the large intestine (colon). The colon is the final part of the digestive tract. Colon cancer typically affects older adults, though it can happen at any age. It usually begins as small, noncancerous (benign) clumps of cells called polyps that form on the inside of the colon. Over time some of these polyps can become colon cancers. More...
17 Jun 2021
Image: The QIAsymphony SP enables sample preparation of DNA, RNA, and bacterial and viral nucleic acids from a wide range of starting materials (Photo courtesy of Qiagen)

Liquid Biopsies Detect Pediatric Bone Tumors Based on Epigenetic Profiles

Sequencing of cell-free DNA (cfDNA) in the blood of cancer patients (liquid biopsy) provides attractive opportunities for early diagnosis, assessment of treatment response, and minimally invasive disease monitoring. As a consequence, cfDNA analysis holds great promise for precision oncology and personalized therapies, and is currently evaluated in a broad range of clinical studies. More...
17 Jun 2021
Image: The CFX384 Touch real-time PCR detection system (Photo courtesy of Bio-Rad)

Genomic Differences Cause Racial Disparities in Prostate Cancer

Prostate cancer is a disease defined by the abnormal growth of cells. These abnormal cells can proliferate in an uncontrolled way and, if left untreated, form tumors which may metastasize or spread to other parts of the body. Prostate cancer (PCa) is the most common solid organ malignancy in men, with 174,650 new diagnoses and 31,620 deaths expected in 2019 in the USA alone. More...
17 Jun 2021
Image: Comparison of brain tissue from a healthy individual and an Alzheimer\'s disease (AD) patient, demonstrating extent of neuronal death (Photo courtesy of [U.S.] National Institutes of Health via Wikimedia Commons)

Plasma Levels of Neurofilament Light Chain Protein Accurately Identify Neurodegenerative Disease Patients

A recent paper indicated that levels of neurofilament light chain (NfL) protein in the blood can be used to identify individuals who might have a neurodegenerative disease such as Alzheimer's disease (AD), Down's syndrome dementia, amyotrophic lateral sclerosis (ALS), atypical parkinsonian disorders, or frontotemporal dementia when clinical symptoms are not definitive. More...
16 Jun 2021
Image: Mucin proteins (green) in a sample of airway mucus (Photo courtesy of University of North Carolina)

A Mucin Protein Is a New Prognostic Biomarker for Chronic Obstructive Pulmonary Disease

The mucin protein MUC5AC has been shown to be a novel biomarker for chronic obstructive pulmonary disease (COPD) prognosis and for testing the efficacy of potential therapeutic agents. More...
15 Jun 2021
Image: An automated Leica BOND-III immunostainer (Photo courtesy of Leica Biosystems)

Low-Cost Transcriptional Diagnostic Accurately Categorizes Lymphomas

Lymphoma is a cancer of the lymphatic system, which is part of the body's germ-fighting network. The lymphatic system includes the lymph nodes (lymph glands), spleen, thymus gland and bone marrow. Lymphoma can affect all those areas as well as other organs throughout the body. More...
14 Jun 2021
Image: Crypts and buds in the small intestine and colon (Photo courtesy of Dr. Maree Faux, Walter and Eliza Hall Institute)

Circulating Tumor DNA Following Surgery Predicts Colorectal Cancer Recurrence

 According to a recent paper, levels of circulating tumor DNA (ctDNA) – which can be measured using noninvasive liquid biopsy – predict the likelihood of recurrence of colorectal cancer following surgery. More...
14 Jun 2021
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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