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Molecular Diagnostics

Image: Schematic Diagram of the Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer (Photo courtesy of MD Anderson Cancer Center).

Molecular Differences Discovered Among Ovarian Cancer Subgroups

Ovarian cancer is a highly diverse disease with a high rate of overall mortality. High-grade serous ovarian cancer (HGSC) is the most common and aggressive type of epithelial ovarian cancer, exhibiting high levels of tumor heterogeneity and variable clinical outcomes. More...
28 Apr 2020
Image: Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing (Photo courtesy of University of Manchester).

Human NK Cells Identified by Single-Cell RNA Sequencing

Natural killer (NK) cells are cytotoxic lymphocytes that are crucial for viral defense as well as detecting and killing cancer cells. This cell type is therefore of great interest for cancer immunotherapy. More...
27 Apr 2020
Image: Histological photomicrograph of a colonic biopsy showing a crypt abscess, a classic finding in ulcerative colitis (Photo courtesy of KGH).

Important Genetic Mechanism Behind Inflammatory Bowel Disease Revealed

The two main forms of Inflammatory Bowel Disease (IBD), Crohn's disease and ulcerative colitis, have an important genetic component. More than 240 genetic regions have been identified that associate with IBD, more than any other pathological condition that has been studied. More...
23 Apr 2020
Image: Representation of the molecular structure of tubulin protein (Photo courtesy of Wikimedia Commons)

Acetylated Tubulin Is a Biomarker for Severe Depression

A recent study suggested that the structural protein tubulin could serve as a novel diagnostic biomarker for severe depression. More...
23 Apr 2020
Image: Mass cytometry with Helios uses CyTOF technology to enable deep profiling of translational and clinical samples across a range of cell surface and intracellular markers (Photo courtesy of Fluidigm).

Missing BAP1 Gene Associated with Immunosuppressive Molecules in Uveal Melanoma

Uveal melanoma is a cancer (melanoma) of the eye involving the iris, ciliary body, or choroid (collectively referred to as the uvea). Tumors arise from the pigment cells (melanocytes) that reside within the uvea and give color to the eye. More...
22 Apr 2020
Image: Micrograph showing a human astrocyte growing in cerebral culture. An elevation in astrocyte protein markers was associated with an anti-inflammatory state in brains of patients with Alzheimer’s disease (Photo courtesy of Wikimedia Commons)

Large Proteomics Study Identifies New Fluid Biomarkers for Diagnosis of Alzheimer’s Disease

A recent study identified proteins and biological processes in brains from Alzheimer’s disease (AD) that may serve as diagnostic fluid biomarkers and potential therapeutic targets for the disease. More...
22 Apr 2020
Image: The lateral flow strips show three patient samples that are negative for BK virus (13,14,15) and three patient samples that are positive (16,17,18). Presence of the upper band indicates a positive test result (Photo courtesy of Dr. Michael Kaminski, Max Delbrück Center for Molecular Medicine)

A Non-Invasive Urine Test for Prediction of Kidney Transplant Failure

A non-invasive test that predicts potential kidney transplant failure combines the CRISPR gene editing tool with a lateral-flow visual readout procedure to analyse urine samples from transplantation recipients. More...
21 Apr 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.

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