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Hematology

Image: The BD FACSCalibur fluorescent activated cell sorter platform allows users to perform both cell analysis and cell sorting in a single benchtop system (Photo courtesy of BD Biosciences).

sTNFR2 Revealed as a Novel Diagnostic Biomarker for Acute ATL

Adult T-cell leukemia/lymphoma (ATL) is a mature T-cell neoplasm associated with human T-cell leukemia virus type 1 (HTLV-1). Although only about 5% of HTLV-1 carriers progress to ATL, early diagnosis is challenging because of the lack of ATL biomarkers. Soluble tumor necrosis factor 2 (sTNFR2) is a novel and promising diagnostic biomarker for acute ATL. More...
07 Apr 2020
Image: Photomicrograph of normal plasma cells from a bone marrow aspirate (Photo courtesy of Peter Anderson).

Molecule in Lymphatic System Implicated in Autoimmune Diseases

A healthy immune system defends the body against diseases and infection. When someone has an autoimmune disease, the immune system malfunctions and the body mistakenly attacks healthy cells, tissues and organs. Rheumatoid arthritis, lupus and scleroderma are examples of autoimmune diseases. More...
02 Apr 2020
Image: Factors associated with acute respiratory distress syndrome (ARDS) In COVID-19 identified (Photo courtesy of the Brian Orelli, PhD).

Factors Associated with ARDS in COVID-19 Identified

 Patients with COVID-19 present primarily with fever, myalgia or fatigue, and dry cough. Although most patients are thought to have a favorable prognosis, older patients and those with chronic underlying conditions may have worse outcomes. More...
30 Mar 2020
Image: The XE-5000 Hematology Analyzer is a high volume analyzer that offers unique clinical parameters to aid in better patient care (Photo courtesy of Sysmex Corporation).

Prognostic Values of Platelet Parameters in Gynecological Tumors Patients

 Gynecologic cancers often involve the uterus, ovaries, cervix, vulva, vagina, fallopian tubes, or the peritoneum. The most common gynecologic cancer in the USA is endometrial cancer, followed by ovarian cancer. Many gynecologic cancers manifest as pelvic masses. More...
24 Mar 2020
Image: Sacroiliac joint biopsy specimen of a 29 year old male patient with ankylosing spondylitis. The biopsy specimen shows a subchondral cellular infiltrate partly invading the cartilage. Fibroblasts and activated lymphocytes are seen in the infiltrate. In between are areas of calcification and bone formation (Photo courtesy of Professor J. Braun).

Fibrinogen-Albumin Ratio Correlated to Ankylosing Spondylitis Disease Activity

 Ankylosing spondylitis (AS) is a systematic inflammatory autoimmune disease that primarily involves the spine and sacroiliac joints. Typically the joints where the spine joins the pelvis are also affected and occasionally other joints such as the shoulders or hips are involved. Back pain is a characteristic symptom of AS, and it often comes and goes. More...
23 Mar 2020
Image: The Agilent 4200 TapeStation system is an established automated electrophoresis tool for DNA and RNA sample quality control (Photo courtesy of Agilent Technologies).

NGS Identifies Genomic Characteristics of Pediatric Leukemia

 Pediatric leukemias have a diverse genomic landscape associated with complex structural variants, including gene fusions, insertions and deletions, and single nucleotide variants. Routine karyotype and fluorescence in situ hybridization (FISH) techniques lack sensitivity for smaller genomic alternations. More...
19 Mar 2020
Image: The Gallios flow cytometer provides efficient acquisition of superior quality data from up to 10 colors with advanced optical design for enhanced sensitivity for multicolor assays (Photo courtesy of Beckman Coulter).

Minimal Residual Disease Assessed in AL Amyloidosis Patients

 Amyloid light-chain (AL) amyloidosis, also known as primary amyloidosis, is the most common form of systemic amyloidosis in the USA. Despite achieving a hematologic complete response after treatment, many patients with AL amyloidosis do not attain recovery of organ function and/or experience hematologic relapse. More...
17 Mar 2020
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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