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Immunology

Image: A histopathology of classic Mycosis fungoides. This skin biopsy specimen demonstrates an atypical lymphocytic infiltrate going up into the epidermis (epidermotropism) in the absence of epidermal edema (spongiosis). The collection of atypical lymphocytes surrounding a Langerhans cell is a Pautrier microabcess, the hallmark of classic MF (Photo courtesy of the University of Pennsylvania).

Tool Predicts Deadly Form of Mycosis Fungoides

Mycosis fungoides (MF), the most common cutaneous T cell lymphoma (CTCL) is a malignancy of skin-tropic memory T cells. Most MF cases present as early stage (stage I A/B, limited to the skin), and these patients typically have a chronic, indolent clinical course. More...
21 May 2018
Image: Mast cells obtained from the human bone marrow; May-Grünwald/Giemsa stain of a resting human mast cell and a mast cell following activation-induced degranulation. Note the loss of granule staining (Photo courtesy of University Hospital of Bonn).

Mast Cell Activation Test Diagnoses Allergic Diseases

Peanut allergies are among the most common food allergies in children. Currently, doctors diagnose peanut allergy using a skin-prick test or immunoglobulin E (IgE) test, but this may result in over-diagnosis or false-positives and it cannot differentiate between sensitivity and true food allergy. More...
16 May 2018
Image: The LSR II flow cytometer (Photo courtesy of BD Bioscience/Albert Einstein College of Medicine).

CSF B Cells Characterized in Virus-Associated Diseases

Regulation of the local immune response is crucial in protecting the central nervous system (CNS) from viral infection and immunopathologically mediated tissue damage. More...
14 May 2018
Image: The low-cost, portable laboratory on a phone that can interpret results from a microplate assay (Photo courtesy of Washington State University).

Smart Phone Reader Detects Common Pathogens

In rural or low resource areas, doctors sometimes must rely on a patient's symptoms or use their own judgement in looking at test sample color results to determine whether a patient has an infection. More...
10 May 2018
Image: The Simoa 2.0, ultrasensitive immunoassay platform used for measuring plasma tau and serum NfL (Photo courtesy of Quanterix).

Blood-Based Biomarker Assessed for Subtle Brain Injury

A high-sensitive blood test can aid concussed hockey players when it might be safe to return to play. The test has identified a superior blood-based biomarker for assessing subtle brain injury. More...
10 May 2018
Image: The small plastic chip about the size of a credit card that can deliver the same diagnostic information as a bone marrow biopsy but using a simple blood draw instead (Photo courtesy of the University of Kansas).

Chip-Based Blood Test Developed for Multiple Myeloma

The diagnosis of multiple myeloma, a cancer affecting plasma cells, traditionally forces patients to suffer through a painful bone biopsy. Doctors insert a bone-biopsy needle through an incision to get a bone marrow sample or make a larger incision and remove a section of bone via surgery. More...
03 May 2018
Image: A positive C. DIFF QUIK CHEK COMPLETE. The assay simultaneously tests for GDH and Toxins A & B providing actionable C. difficile results in less than 30 minutes (Photo courtesy of Alere).

Clostridium difficile Examined by Different Methods

The epidemiology of Clostridium difficile infection (CDI) has shifted in the last decade and is now affecting populations previously at low risk to include healthy adults, peripartum women and young children. More...
30 Apr 2018
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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