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Immunology

Image: The Cytomics FC500 Flow Cytometer System (Photo courtesy of Beckman Coulter Life Sciences)

T-Cell CD27 Expression Assessed for Smear-Negative Tuberculosis

Mycobacterium tuberculosis (MTB) and its related disease tuberculosis (TB) are infectious diseases with a worldwide focus. Although both vaccines and anti-TB drugs are available, there is a global focus on illness diagnosis in smear-negative and latent tuberculosis infectious populations (SN-TB and LTBI). More...
27 Jul 2021
Image: The HE4 EIA is an enzyme immunometric assay for the quantitative determination of human epididymis protein 4 (HE4) in human serum. HE4 is consistently expressed in patients with ovarian cancer, and it has demonstrated increased sensitivity and specificity over that of CA125 alone (Photo courtesy of Fujirebio)

Immunoassays Compared for Serum HE4 Estimation for Ovarian Cancer

Ovarian cancer is the sixth most common cancer in women and the leading cause of death from gynecological malignancy in the UK. Cancer antigen 125 (CA125) is the most widely used diagnostic biomarker for ovarian cancer; however it lacks the diagnostic accuracy to reliably detect ovarian cancer at an early stage. More...
26 Jul 2021
Image: The ProSpecT Rotavirus Microplate ELISA Assay (Photo courtesy of Thermo Fisher Scientific)

Rotavirus Co-Infection with Diarrheagenic Pathogens Detected by Different Methods

Diarrhea is the second most common cause of childhood mortality worldwide, with Group A Rotavirus (RVA) recognized as a leading diarrheagenic agent, causing 38% of acute diarrhea among children aged five and below worldwide. More...
14 Jul 2021
Image: The MAGLUMI 800 Automatic immunoassay analyzer (Photo courtesy of Snibe)

Automated Immunoassays Evaluated for Immune Response to SARS-CoV-2

As part of the fight against the SARS-Cov-2 epidemic, laboratories have a critical role in assessing the reliability of new serological assays before taking part of diagnostic protocols or made available broader to the community and to evaluate commutability between assays. More...
12 Jul 2021
Image: Elevated levels of two inflammatory proteins, IL-12p70 and IFN-γ, were associated with slower cognitive decline in older adults (Photo courtesy of Scientific Animations Inc)

Two Inflammatory Proteins Linked with Slower Cognitive Decline

Previous meta-analyses of case-control and prospective cohort studies showed that cytokines and inflammatory markers, such as interleukin-6 (IL-6), C-reactive protein (CRP), and others are elevated in Alzheimer's dementia cases and predicted incident of all-cause dementia. More...
08 Jul 2021
Image: Enzyme-linked immunosorbent assay (ELISA) kit for Fatty acid-binding proteins 4 (FABP4) (Photo courtesy of Biovendor R&D)

FABP4 Concentrations Quantified in Proliferative Diabetic Retinopathy

Proliferative diabetic retinopathy (PDR), a progressive and serious stage of diabetic retinopathy (DR) due to retinal ischemia, is characterized by neovascularization (NV), vitreous hemorrhaging (VH) and tractional retinal detachment (TRD), all of which are major causes of blindness in patients with diabetes mellitus (DM). More...
07 Jul 2021
Image: The IDS-iSYS Multi-Discipline Automated System Analyzer (Photo courtesy of Immunodiagnostic Systems)

Two Immunoassays Compared for Determination of Serum Vitamin D

Vitamin D is a fat-soluble steroid prohormone that is generated mainly in the skin by photochemical conversion of 7-dehydrocholesterol. 25-hydroxyvitamin D (25(OH)D) is its main storage form and is present in blood at very high concentration with respect to the active form 1,25-dihydroxyvitamin D. More...
06 Jul 2021
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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