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Immunology

Image: The MACSQuant Analyzer 10 flow cytometer has three lasers (405, 488, 638 nm), two scatter (FSC, SSC) and seven fluorescent channels (Photo courtesy of Miltenyi Biotec)

Proinflammatory T Cell Polarization Investigated in Early Knee Osteoarthritis

In osteoarthritis (OA), the cartilage in the knee joint gradually wears away. As the cartilage wears away, it becomes frayed and rough, and the protective space between the bones decreases. This can result in bone rubbing on bone, and produce painful bone spurs. Osteoarthritis develops slowly and the pain it causes worsens over time. More...
01 Feb 2021
Image: The Simoa HD-X fully automated immunoassay platform with multiplexing and custom assay capability (Photo courtesy of Quanterix Corporation).

Alzheimer's Progression Tracked with Blood Biomarkers

Alzheimer disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau in the brain. These neuropathological changes are believed to take part in a cascade of events that result in a characteristic neurodegeneration pattern followed by progressive cognitive impairment. More...
28 Jan 2021
Image: The Bio-Plex Pro Human Cytokine Screening 48-plex panel (Photo courtesy of Bio-Rad Laboratories).

Early Differences in Cytokine Production Distinguish Severity of COVID-19

Most COVID-19 patients experience asymptomatic/mild symptoms, but some suffer critical symptoms requiring intensive care. It is important to determine how asymptomatic/mild patients react to SARS-CoV-2 infection and suppress virus spread. More...
27 Jan 2021
Image: The Leica Bond III stainer is fully automated Immunohistochemical and In Situ Hybridization (IHC and ISH stainer) (Photo courtesy of Leica Biosystems).

Mismatch Repair/Microsatellite Instability Evaluated Using Cytology Effusion Specimens

DNA mismatch repair (MMR) status is routinely assessed in colorectal and endometrial carcinoma as a method of cancer prevention, surveillance in patients with Lynch syndrome and their families, and for prognostic, predictive, and therapeutic implications. More...
25 Jan 2021
Image: Tryptophan metabolism is dysregulated in individuals with Fanconi anemia (Photo courtesy of Cincinnati Children’s Hospital Medical Center).

Tryptophan Metabolism Is Dysregulated in Individuals with Fanconi Anemia

Fanconi anemia (FA) is a complex genetic disorder frequently associated with progressive marrow failure and a strong predisposition to early malignancies, particularly squamous cell carcinomas and hepatocellular carcinomas. More...
20 Jan 2021
Image: The CytoFLEX benchtop flow cytometer features up to three lasers for 13-color flow cytometry (Photo courtesy of Beckman Coulter Life Sciences).

Basophil Activation Test Predicts Pediatric Wheezing Prognosis

Although asthma is a common chronic airway inflammatory disease in children, the natural history of asthma remains unknown. It is difficult to diagnose asthma in children aged under five years because of the complexity of wheezing phenotypes at that age. More...
20 Jan 2021
Image: An enzyme-linked immunoassay (ELISA) for serum neurofilament light chain (Photo courtesy of UmanDiagnostics AB).

Increased Serum Neurofilament Light Portend Worse Prognosis in COVID-19

There is emerging evidence for multifarious neurological manifestations of COVID‐19, while little is known whether they reflect structural damage to the nervous system. The most commonly reported neurological manifestations of COVID-19 were myalgia, headache, altered sensorium, hyposmia, and hypogeusia. More...
19 Jan 2021
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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