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Pathology

Image: A histological preparation from a patient with invasive lobular carcinoma, demonstrating a predominantly lobular growth pattern (Photo courtesy of KGH).

Test Determines If Cancer Patients Require Chemotherapy

Invasive lobular carcinoma (ILC) is the most common special type of breast cancer, and is characterized by functional loss of E-cadherin, resulting in cellular adhesion defects. ILC typically present as estrogen receptor positive, grade 2 breast cancers, with a good short-term prognosis. More...
09 Jul 2019
Image: A histopathology of lymph node with metastatic adenocarcinoma of the colon (Photo courtesy of Dr. Ed Uthman M.D).

Metastases May Form Early in Development of Colorectal Cancer

Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine). Signs and symptoms may include blood in the stool, a change in bowel movements, weight loss, and feeling tired all the time. More...
04 Jul 2019
Image: (A and B) Photomicrographs of the layers of the device; (C) the mold ready for casting and (D) the chip mounted on a slide (Photo courtesy of San Diego State University).

Microfluidic Device Isolates Circulating Tumor Cell Clusters

The three main challenges of cancer treatment are metastases, recurrence, and acquired therapy resistance. These challenges have been closely linked to circulating cancer cell clusters. More...
03 Jul 2019
Image: iPLEX Gold is a SNP genotyping assay that runs on Sequenom\'s MassArray mass spectrometer (Photo courtesy of Sequenom).

New Genetic Link to Premenopausal Breast Cancer Discovered

Breast cancer is the most common cancer in women, with an estimated one out of every eight women expected to develop it in their lifetimes. While environmental factors like smoking, diet or lack of physical activity can lead to cancer, a person's genes also contribute to the risk of getting the disease. More...
03 Jul 2019
Image: The BioMark HD real-time polymerase chain reaction (PCR) platform (Photo courtesy of Fluidigm).

New Biomarker Test Improves Diagnosis of Ovarian Cancer

Ovarian cancer is often discovered at a late stage and has a high mortality rate. Overall 5-year survival is only 30% to 40% after treatment, and there has been no test specific enough to justify screening. More...
02 Jul 2019
Image: A color hereditary cancer risk screening kit (Photo courtesy of Color Genomics).

Pathogenic Variant Carriers Missed by Current Genetic Testing

Current guidelines recommend genetic testing for people who have a personal or family history of cancer that indicates they might be at an increased risk of harboring a pathogenic familial variant, but this approach could miss people who lack any personal or family history. More...
27 Jun 2019
Image: Identifying a metastatic colorectal cancer patient’s Consensus Molecular Subtype (CMS) could help oncologists determine the most effective course of treatment (Photo courtesy of University of Southern California).

Identifying Colorectal Cancer Subtypes Improves Treatment Decisions

Colorectal cancer is the second leading cause of cancer death in the USA, and is expected to cause about 51,000 deaths in 2019, but until now, it was unclear which drugs were most effective for which patients. More...
25 Jun 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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