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Pathology

Image: Axiom Genome-Wide Population-Optimized Human Arrays are genotyping panels that offer the best genetic coverage of rare and common variants for genome-wide disease association studies (Photo courtesy of Thermo Fisher Scientific)

Preemies' Blood Type Tied to Risk for Necrotizing Enterocolitis

Necrotizing enterocolitis (NEC) and focal intestinal perforation (FIP) are two of the most common emergencies of the gastrointestinal tract in preterm infants with very low birth weight (VLBW). The etiology and pathogenesis of NEC and FIP remain poorly understood. More...
21 Jul 2021
Image: Telomerase reverse transcriptase (TERT) expression in non-lentiginous acral melanoma (NLAM) and non-acral cutaneous melanoma (NACM): (A) exhibiting 1+ TERT staining intensity and (B) The intensity of TERT expression and proportion of TERT-positive cells could also vary in cutaneous melanomas (Photo courtesy of MD Anderson Cancer Center)

Telomerase Reverse Transcriptase Protein Expression Evaluated for Melanomas

Telomeres are regions of repetitive nucleotide sequences located at the ends of chromosomes that play a key role in the maintenance of genomic integrity and stability in cells. In normal nonneoplastic somatic cells, telomeres progressively shorten with successive cell divisions. More...
19 Jul 2021
Image: Nanoanalysis of plasma volatile organic compounds used novel DNA-decorated carbon nanotube vapor sensors to noninvasively distinguish ovarian and pancreatic cancer from benign and control samples (Photo courtesy of the University of Pennsylvania)

Electronic Nose Sensor Accurately Detects Ovarian, Pancreatic Cancers

Ovarian cancer is a cancer that forms in or on an ovary. It results in abnormal cells that have the ability to invade or spread to other parts of the body. When this process begins, there may be no or only vague symptoms. Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass. More...
15 Jul 2021
Image: The Super Sensitive 1-STEP Polymer HRP IHC detection kit (Photo courtesy of BioGenix)

Protein Biomarker Helps Diagnose Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC), characterized by dense desmoplastic stroma laid down by pancreatic stellate cells (PSC), has no reliable diagnostic biomarkers for timely detection. More...
14 Jul 2021
Image: Histology of acute pancreatitis. Microscopically, the fat necrosis consists of steatocytes (adipocytes) that have lost their nuclei and whose cytoplasm has a granular pink appearance as seen on the right. Some hemorrhage is seen at the left in this case of acute pancreatitis (Photo courtesy of Texas A&M University)

Biomarkers Diagnose and Predict Acute Pancreatitis

Acute pancreatitis (AP) is an inflammatory reaction caused by the activated pancreatic enzymes in the pancreas, which leads to subsequent pancreatic autodigestion, edema, hemorrhage, necrosis, and even distal organ dysfunction. More...
08 Jul 2021
Image: The Bioanalyzer RNA 6000 Nano assay provides reliable and reproducible characterization of total RNA and mRNA from multiple sample types, from as low as 5 ng of total RNA (Photo courtesy of Agilent)

Respiratory Syncytial Virus Bronchiolitis Has Different Subtypes

Bronchiolitis is the leading cause of hospitalization in infants in the USA, accounting for about 110,000 hospitalizations annually. In addition to the substantial acute morbidity, around 30% of infants hospitalized for bronchiolitis (“severe bronchiolitis”) subsequently develop asthma in childhood. More...
30 Jun 2021
Image: A blood test for glucose may reveal hyperglycemia which has been evaluated as a risk factor in pancreatic cancer (Photo courtesy of Amit Akirov, MD)

Hyperglycemia Evaluated as a Risk Factor in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (pancreatic cancer) has a five-year survival rate of 9%. Most patients are diagnosed with metastatic disease due to late presenting symptoms and only 10% to 20% are able to undergo surgery with a curative intent. More...
23 Jun 2021
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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