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Pathology

Image: A diagram of urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment (Photo courtesy of University College London).

Urine Biopsies Help Monitor Bladder Cancer Treatment

Despite the advances in cancer immunotherapy, only a fraction of patients with bladder cancer exhibit responses to checkpoint blockade, highlighting a need to better understand drug resistance and identify rational immunotherapy combinations. More...
10 Oct 2018
Image: The iChip: The blood sample is passed into the CTC-iChip microfluidic system, which first removes red cells, plasma and free magnetic beads and then sorts out tagged white blood cells, leaving a purified solution of circulating tumor cells (Photo courtesy of Dr. Emre Ӧzkumur, PhD).

Liquid Biopsy Identifies Chronic Liver Diseases

A recently developed liquid biopsy cell-sorting device was able to detect circulating epithelial cells of hepatocyte origin in blood from healthy individuals, patients with chronic liver disease without hepatocellular cancer (HCC), and those with HCC. More...
03 Oct 2018

Standalone HPV Testing Recommended for Cervical Cancer Screening

The number of deaths from cervical cancer in the USA has decreased substantially since the implementation of widespread cervical cancer screening and has declined from 2.8 to 2.3 deaths per 100,000 women from 2000 to 2015. More...
02 Oct 2018
Image: A lunchbox-sized device for nucleic acid quantification that can be powered by sunlight, a flame or electricity enables the diagnosis of disease in settings with unreliable power supply (Photo courtesy of Cornell University).

Cancer Detection Device Proves Effective in Field Testing

A decentralized approach to diagnostics can decrease the time to treatment of infectious diseases in resource-limited settings, yet most modern diagnostic tools require stable electricity and are not portable. More...
01 Oct 2018
Image: Auramine O stained Mycobacterium leprae in FFPE tissue section under ×40 objective of light-emitting diode fluorescence microscope A: Sample with high BI; B. Sample with low BI (Photo courtesy of Armauer Hansen Research Institute).

Molecular and Classical Methods Compared for Leprosy Diagnosis

Mycobacterium leprae is the causative agent of leprosy, a chronic granulomatous infectious disease affecting the skin and peripheral nerves. Leprosy manifests in various forms based on the immunological profiles and bacterial load in patients. More...
27 Sep 2018
Image: The AmplideX PCR/CE C9orf72 assay kit (Photo courtesy of Asuragen).

Dementia Assay Gets Favorable Evaluation

An assay to detect the most common genetic mutation associated with amyotropic lateral sclerosis (ALS) and frontotemporal dementia (FTD) has been shown to have significant advantages over a laboratory-developed test in an evaluation. More...
27 Sep 2018
Image: An ELISA Kit for Kidney Injury Molecule 1 (Kim1) (Photo courtesy of Enzo Life Sciences).

Blood Test May Help Detect Kidney Cancer Earlier

Renal cell carcinoma (RCC) has the potential for cure with surgery when diagnosed at an early stage. Kidney injury molecule-1 (KIM-1) has been shown to be elevated in the plasma of RCC patients. More...
26 Sep 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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