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Pathology

Image: The Biomark microfluidic system for polymerase chain reactions (Photo courtesy of Fluidigm).

Blood Test Monitors Relapsed Serous Ovarian Cancer

The development of blood biomarkers that can be used for early detection of cancer or to measure tumor burden and response to treatment is a major goal of translational cancer studies across all cancer types. More...
09 Feb 2017
Image: MiR-194 drives prostate cancer metastasis by suppressing SOCS2 activity (Photo courtesy of Dr. Luke Selth, University of Adelaide).

Blood Levels of Specific MicroRNA Predict Likelihood of Metastasis

The microRNA (miRNA) that regulates the activity of the ubiquitin ligase enzyme SOCS2 (Suppressor of Cytokine Signaling 2) has been linked to the ability of prostate cancer to metastasize. More...
08 Feb 2017
Image: The Nexera ultra high performance liquid chromatograph (UHPLC) system (Photo courtesy of Shimadzu).

Blood Test for Gut Bacteria Predicts Cardiovascular Events

The bacteria that inhabit the gut digest food and produce metabolites that can have a marked effect on the heart and blood vessels. A molecule called trimethylamine N-oxide (TMAO) could predict this risk not only in the short-term but also the risk of death in the longer term. More...
02 Feb 2017
Image: A histopathology of a desmoplastic-nodular medulloblastoma, stained for reticulin. Reticulin fibers permeate the tumor but are absent in the center of the nodule (Photo courtesy of Dr. Dimitri Agamanolis, MD).

Precision Medicine Advances Pediatric Brain Tumor Diagnosis

Targeted therapies for cancer have significantly improved the treatment of certain types of leukemia, digestive system tumors, and breast cancer, among other malignancies. More...
02 Feb 2017
Image: The circulating tumor cells (CTC)-iChip is composed of two separate microfluidic devices that house three different microfluidic components engineered for inline operations (Photo courtesy of Massachusetts General Hospital).

Digital CTC Assay Improves Liver Cancer Diagnosis

Liver cancer, including hepatocellular carcinoma (HCC), is the second highest cause of cancer death in the world. HCC is particularly prevalent in developing countries, where its incidence is driven by infection with the hepatitis B virus, which now affects more than 248 million individuals. More...
01 Feb 2017
Image: The free Prostate-Specific Antigen (PSA) / total PSA fraction is significantly diminished in men with prostate cancer since almost all of the PSA is bound. When the fraction is under 10%, the risk of prostate cancer is high. When it is above 25%, the elevation of PSA is probably related to benign hyperplasia (Photo courtesy of Dianon Pathology).

Rapid Method Determines Free and Total PSA in Serum

Prostate-Specific Antigen (PSA) is a protein produced by prostate gland cells, circulates through the body in two ways: either bound to other proteins or on its own. PSA traveling alone is called free PSA. The free-PSA test measures the percentage of unbound PSA; the PSA test measures the total of both free and bound PSA. More...
01 Feb 2017
Image: A histopathology of prostate cancer – The presence of luminal comedo necrosis in a cancer gland space is sufficient to diagnose Gleason grade 5 (Photo courtesy of Kenneth Iczkowski, MD).

Cancer Biomarkers Identify Candidates for Aggressive Treatment

Prostate cancer (PC) is the second leading cause of male cancer death in the USA with an estimated 26,000 deaths in 2016. Two-thirds of all PC deaths observed in the US are men with localized disease who developed metastasis. More...
26 Jan 2017
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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