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Pathology

Image: Telomeres at the end of the chromosomes protecting against DNA deterioration (Photo courtesy of Dr. Joseph Raffaele, MD).

Telomere Biomarker Blood Test Predicts Cancer Years In Advance

Telomeres are sequences of DNA on the ends of chromosomes that stop them fraying and losing their integrity, but they gradually shorten as one ages and by the time one grow up they are half the length they were when a person was born, then they halve again as they enter old age.  More...
12 May 2015
Image: Estrogen receptor (ER)-positive breast cancer surgical pathology specimen stained for ER by immunohistochemistry. Most of the cancer cell nuclei stain dark brown, strongly positive for ER (Photo courtesy of Ronald S. Weinstein, MD).

Standard Clinical Assays Obscure Breast Cancer Subtype Diversity

The classification systems that categorize breast cancers based on estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression levels may obscure the heterogeneity of other key tumor features.  More...
10 May 2015
Image: BMG FLUOstar Omega plate reader (Photo courtesy of BMG LABTECH).

Rapid Method Detects Creutzfeldt-Jakob Disease in Cerebrospinal Fluid

A long-standing problem in dealing with various neurodegenerative protein misfolding diseases is early and accurate diagnosis and this is particularly important with human prion diseases. More...
05 May 2015
Image: The FluoView 500 Laser Scanning Confocal Microscope (Photo courtesy of Olympus Inc.).

Protein Biomarker Signals More Aggressive Prostate Cancer

Prostate cancer, the most common male malignancy, is frequently associated with bone metastases and a major challenge for treatment is to identify factors controlling tumor growth and metastasis. More...
05 May 2015
Image: The Aperio ScanScope XT Slide Scanner (Photo courtesy of Aperio Technologies).

Protein Biomarker Discovered for Uterine Cancer

A new biomarker has been discovered which makes it possible to identify women with uterine cancer who have a high risk of recurrence. More...
05 May 2015
Image: Depiction of genomic imbalances detected in patients with chronic kidney disease. The human chromosomes are shown (numbered). The colored bars represent the pathogenic genomic deletions (red) and duplications (blue) detected in a patient. In total, the study identified 21 different genetic lesions in 31 patients, indicating that most patients had a unique genomic pathology. The size of each bar is proportional to the size of the genomic lesion (Photo courtesy of Dr. Ali Gharavi, Columbia University).

Analysis of Chromosome Abnormalities May Aid Diagnosis of Chronic Kidney Disease in Children

A recent paper discussed the possibility of using a panel of genetic abnormalities to aid in diagnosing children with chronic kidney disease. More...
04 May 2015
Image: Representation of a member of the APOBEC family of deaminase enzymes (Photo courtesy of Wikimedia Commons).

Gene Mapping Reveals Mutation in Myeloma Patients Linked to High Risk of Treatment Failure

Gene mapping of patients suffering from myeloma has enabled the identification of a genetic signature linked to the likelihood of the disease becoming more genetically complex and more likely to evolve into treatment-resistant forms. More...
04 May 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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