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Molecular Diagnostics

Image: FoundationOne liquid biopsy assays were used to study the association of circulating tumor DNA and circulating tumor cells after neoadjuvant chemotherapy with disease recurrence in patients with triple-negative breast cancer (Photo courtesy of Foundation Medicine).

Circulating Tumor DNA Associated with Triple-Negative Breast Cancer Recurrence

Patients with early-stage triple-negative breast cancer (TNBC) are frequently treated with neoadjuvant chemotherapy, based on the increased risk for recurrence and death associated with this category of tumors. More...
27 Jul 2020
Image: The RaDaR (Residual Disease and Recurrence) assay detects circulating tumor DNA (ctDNA) found in the bloodstream (Photo courtesy of Inivata).

CtDNA Assay for Cancer Recurrence, MRD Applications Demonstrated

Circulating tumor DNA (ctDNA) is found in the bloodstream and refers to DNA that comes from cancerous cells and tumors. Most DNA is inside a cell's nucleus. As a tumor grows, cells die and are replaced by new ones. The dead cells get broken down and their contents, including DNA, are released into the bloodstream. More...
22 Jul 2020
Image: A scanning electron microscope image of normal circulating human blood showing red blood cells, several types of white blood cells including lymphocytes, a monocyte, a neutrophil and many small disc-shaped platelets (Photo courtesy of [U.S.] National Cancer Institute)

COVID-19 Patients with Lymphocytopenia Are Likely to Suffer Severe Disease Symptoms

An easily recognizable feature in blood samples may be an indicator of whether a COVID-19 patient will be likely to suffer from a severe form of the disease. More...
22 Jul 2020
Image: Three-dimensional ball-and-stick model of asymmetric dimethylarginine (Photo courtesy of Wikimedia Commons)

Blood Plasma Biomarker Linked to Middle Age Cognitive Decline

Analysis of plasma asymmetric dimethylarginine concentrations showed that elevated levels of this substance could be used as a biomarker to predict worsening cognitive performance in older adults. More...
21 Jul 2020
Image: The Immunogenomic Landscape of Hematological Malignancies (Photo courtesy of Helsinki University Hospital).

Immunogenomic Landscape of Hematological Malignancies Mapped

The reaction of the body's immune system against cancer can be thought of as a cycle. Cancer cells contain proteins that differ from proteins in other tissue. Their components, known as antigens, have to be presented to the T cells of the immune system by the cancer cells. More...
20 Jul 2020
Image: Summary of changes FKBPL and CD44 changes throughout gestation in pregnancies complicated by pre-eclampsia (Photo courtesy of Oxford Press)

Elevated Levels of Two Protein Biomarkers Indicate Potential for Development of Pre-Eclampsia

A pair of novel protein biomarkers has been identified in the blood of asymptomatic pregnant women that can be used to predict the potential onset of pre-eclampsia. More...
16 Jul 2020
Image: The Dimension Vista 500 Intelligent Laboratory System (Photo courtesy of Siemens Healthineers).

Clonal Hematopoiesis of Indeterminate Potential Associated with hsC-Reactive Protein

Clonal hematopoiesis (CH) occurring in normally aging subjects, initially suggested by X-chromosome inactivation studies, is caused by acquired mutations in genes recurrently mutated in hematological cancers, and in non-driver candidates. More...
14 Jul 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.

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