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Hematology

Image: STEMvision: Automated and standardized colony counting for the hematopoietic colony-forming unit (CFU) assay (Photo courtesy of STEMCELL Technologies).

Chronic Lymphocytic Leukemia Increases Peripheral Blood Hematopoietic Stem Cells

Chronic lymphocytic leukemia (CLL) is an indolent B-cell malignancy invariably infiltrating the bone marrow. The disease remains incurable, and after emergence of therapy, resistant disease patients succumb to infections because of secondary bone marrow failure. More...
31 Dec 2020
Image: Acute Lymphoblastic Leukemia: lymphoblasts appear small with a thin rim of cytoplasm (Photo courtesy of Peter Maslak MD).

Next-Generation Sequencing Detects Residual Disease in Acute Lymphoblastic Leukemia

The use of next-generation sequencing (NGS) to detect residual disease in acute lymphoblastic leukemia (ALL) patients after treatment can better gauge their risk of relapse and overall survival than multiparameter flow cytometry. More...
24 Dec 2020
Image: BD enzyme-linked immunosorbent assays for natural C5b-9 in serum, plasma, and other biological samples (Photo courtesy of BD Biosciences).

Elevated Soluble C5b9 Biomarker Found in SARS-CoV-2 Infected Children

Most children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have mild or minimal disease, with a small proportion developing severe disease or multisystem inflammatory syndrome in children (MIS-C). More...
21 Dec 2020
Image: The Yumizen H2500 Automatic Hematology Analyzer (Photo courtesy of Horiba)

Two Automated Hematology Analyzers Compared for Performance

A complete blood count (CBC) is a highly automated laboratory test. The use of highly advanced measurement methods increases the accuracy and sensitivity of the determination of individual hematological parameters, especially in the case of white blood cells differentiation. More...
17 Dec 2020
Image: The XN-9000 Automated Hematology Analyzer (Photo courtesy of Sysmex Corporation).

Diagnostic Assays Evaluated for Vitamin B12 and Folate Deficiency

Current guidelines pertaining to diagnosing macrocytic anemia in association with vitamin B12 and folate deficiency recommend that vitamin B12, folate, homocysteine, and methylmalonic acid assays should be assessed concurrently due to their close relationship in metabolism. More...
07 Dec 2020
Image: The Tapestri Platform is the first and only single-cell multi-omics platform that is capable of simultaneously providing both genotype and phenotype data from the same cell, across thousands of cells (Photo courtesy of Mission Bio).

Single-Cell Analysis Elucidates Mutation Patterns in Myeloid Malignancies

Myeloid malignancies are clonal diseases of hematopoietic stem or progenitor cells. Myeloid malignancies, including acute myeloid leukemia (AML), arise from the expansion of these hematopoietic stem and progenitor cells that acquire somatic mutations. More...
01 Dec 2020
Image: HemosIL RecombiPlasTin 2G assay: A high sensitivity thromboplastin reagent based on recombinant human tissue factor (RTF) for the quantitative determination in human citrated plasma of Prothrombin Time (Photo courtesy of Instrumentation Laboratories).

Anticoagulant Adjustment Evaluated Using Different Prothrombin Time Tests

Preanalytical variables may affect the results of routine coagulation assays. One important variable is hematocrit (Ht), which affects coagulation testing results. A sample with high Ht has lower plasma quantity, resulting in a dilution effect on the sample by an excess of the anticoagulant sodium citrate. More...
26 Nov 2020
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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