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Hematology

Image: Comparison of histology between ulcerative colitis and Crohn’s disease (Photo courtesy of R. J. Xavier & D. K. Podolsky).

New Diagnosed Anemia Linked to Crohn’s Disease Risk

Inflammatory bowel disease (IBD) includes Crohn’s disease (CD) and ulcerative colitis (UC). IBD is a chronic inflammatory gastrointestinal disorder that involves complex interactions among genetic, environmental, immunological, and microbiological factors. More...
28 Sep 2020
Image: the new XS-500ix Automated Hematology Analyzer (Photo courtesy of Sysmex Corporation).

Hematological Parameters Evaluated for Cervicocranial Arterial Dissection Stroke

As artery detachment, artery dissection refers to the vascular disease in which blood flow enters the artery wall and causes dissection of vascular wall. Cervicocranial arterial dissection (CCAD) can lead to stenosis or occlusion of the lumen has become one of the most frequent causes for ischemic stroke in the young. More...
23 Sep 2020
Image: The Mindray BC-2800 Fully Automatic Hematology Analyzer with 19 Parameters for CBC /Blood Cell Test for Hospital Use (Photo courtesy of Mindray).

Quantitative Agglutination Determined on Automatic Hematology Analyzer

The currently available agglutination identification methods are slide methods and test tube methods. Based on the distribution, uniformity and comprehensive changes of non-aggregated cells and agglutinating cells in the liquid, the agglutination degree and strength can be determined by the naked eye. More...
16 Sep 2020
Image: The LecChip and GlycoStation were used to identify subtle surface ABO blood group glycoprotein density variations (Photo courtesy of Glycotechnica).

Complex ABO Glycan Phenotypes Predicted by Lectin Microarrays

Serological classification of individuals as A, B, O, or AB is a mainstay of blood banking. ABO blood groups or ABH antigens, in addition to other surface glycans, act as unique red blood cell (RBC) signatures and direct immune responses. ABO subgroups present as weakened, mixed field, or unexpected reactivity with serological reagents, but specific designations remain complex. More...
16 Sep 2020
Image: Bone marrow smear in T-cell acute lymphoblastic leukemia shows pleomorphic blasts cells and smear cells. Two of the blasts have a hand-mirror conformation (arrows) (Photo courtesy of Ke Xu, MD).

Positive Lymphocyte Gene Rearrangement Evaluated for Hematologic Malignancies

The diagnosis of a lymphoid malignancy requires the establishment of monoclonality of a lymphocyte population through morphologic assessment and laboratory testing, such as flow cytometry, immunohistochemistry, and cytogenetic analysis. More...
08 Sep 2020
Image: A blood film with a normal mature lymphocyte with a single large nucleus is seen on the left, compared to two segmented neutrophils on the right with multiple nuclear lobes. The lymphocytes are decreased in comorbid diabetes and COVID-19 patients (Photo courtesy of Ed Reschke).

Lymphocyte Count Correlated to Comorbid Diabetes and COVID-19

The coronavirus disease (COVID-19) that erupted in China since December 2019 and has gradually spread throughout the world. At present, it has caused tens of thousands of deaths, and the efficacy of certain antiviral drugs is still under review. More...
03 Sep 2020
Image: Higher prevalence of clonal hematopoiesis found in the blood and bone marrow of older healthy volunteers (Photo courtesy of Sorbonne University).

Clonal Hematopoiesis Prevalence Determined in Healthy Donors

Clonal hematopoiesis of indeterminate potential (CHIP) is defined as the presence of a clone at more than 2% of variant allele frequency (VAF) in peripheral blood (PB) of individuals with no evidence of hematologic disease. More...
02 Sep 2020
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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